从事传染病临床医疗、教学、科研20余年。曾赴德国Duisburg-Essen大学胃肠肝病科学习，获医学博士学位。中华医学会自身免疫性肝病学组委员、中华医学会肝病学分会青年委员、中华医学会肝病学分会肝病基础医学与实验诊断协作组委员、湖北省医学生物免疫学会免疫治疗不良反应MDT专家委员会常务委员、湖北省艾滋病防治协会理事、湖北省卫健委疫情处置工作组成员。

对病毒性肝炎、自身免疫性肝病、各种原因导致肝功能不良的鉴别、肝硬化和肝衰竭等终末期肝病；各种感染发热性疾病积累了丰富的临床和科研经验。

主持多项国家自然科学基金课题，获国家发明专利两项，以第一作者或通讯作者在国际肝脏病学、病毒学和免疫学专业杂志“Nature Communication”、“Hepatology”、“Journal of Virology”、“Journal of Immunology”等杂志上发表多篇文章。

代表文章:

1.Zou S, Du Y, Huang S, Chen M, Yang X, Li S, Chen Y, Han M, Li J, Yu Q, Littwitz-Salomon E, Huang H, Trilling M, Liu S, Pei R, Liu J, Wang B, Zheng X, Lu M, Dittmer U, Sun S*, Yang D*, Wu J*. Simultaneous or prior activation of intrahepatic type I interferon signaling leads to hepatitis B virus persistence in a mouse model. J Virol. 2021 Nov 23;95(24):e0003421. doi: 10.1128/JVI.00034-21. Epub 2021 Sep 22. PMID: 34550772; PMCID: PMC8610600.

2.Wu J#, Liang BY, Fang YH, Wang H, Yang XL, Shen S, Chen LK, Li SM, Lu SH, Xiang TD, Liu J, Le-Trilling VTK, Lu MJ, Yang DL, Deng F, Dittmer U, Trilling M, Zheng X. Occurrence of COVID-19 Symptoms During SARS-CoV-2 Infection Defines Waning of Humoral Immunity. Front Immunol. 2021 Aug 16;12:722027. doi: 10.3389/fimmu.2021.722027. PMID: 34489971; PMCID: PMC8416539.

3.Wu J#, Liang B #, Chen C #, Wang H #, Wu J, Liang B, Chen C, Wang H, Fang Y, Shen S, Yang X, Wang B, Chen L, Chen Q, Wu Y, Liu J, Yang X, Li W, Zhu B, Zhou W, Wang H, Li S, Lu S, Liu D, Li H, Krawczyk A, Lu M, Yang D, Deng F, Dittmer U, Trilling M, Zheng X. SARS-CoV-2 infection induces sustained humoral immune responses in convalescent patients following symptomatic COVID-19. Nat Commun. 2021 Mar 22;12(1):1813.. 

4.Du Y; Yan H; Zou S; Khera T; Li J; Han M; Yang X; Wang B; Liu J; Sun S; Zheng X; Dittmer U; Lu M; Yang D; Wedemeyer H*; Wu J*; Natural Killer Cells Regulate the Maturation of Liver Sinusoidal Endothelial Cells Thereby Promoting Intrahepatic T-Cell Responses in a Mouse Model, Hepatology Communications, 2021 Feb 5;5(5):865-881. 

5.Du Y, Yang X, Li J, Sokolova V, Zou S, Han M, Yan H, Wey K, Lu M, Dittmer U, Yang D, Epple M*, Wu J*. Delivery of toll-like receptor 3 ligand poly(I:C) to the liver by calcium phosphate nanoparticles conjugated with an F4/80 antibody exerts an anti-hepatitis B virus effect in a mouse model. Acta Biomater. 2021, S1742-7061(21)00073-8. 

6.Huang S#, Zou S#, Chen M, Gao X, Chen L, Yang X, Yu Q, Zhao X, Du Y, Yang X, Lin Y, Wang B, Lu Y, Liu J, Zheng X, Gong F, Lu M, Yang D*, Wu J*. Local Stimulation of Liver Sinusoidal Endothelial Cells with a NOD1 Agonist Activates T Cells and Suppresses Hepatitis B Virus Replication in Mice. J Immunol. 2018, 200(9):3170-3179. 

7.Wu J#, Huang S, Zhao X, Chen M, Lin Y, Xia Y, Sun C, Yang X, Wang J, Guo Y, Song J, Zhang E, Wang B, Zheng X, Schlaak JF, Lu M*, Yang D*. Polyinosinic-polycytidylic acid treatment leads to the interferon-dependent clearance of hepatitis B virus in a hydrodynamic injection mouse model.J Virol. 2014, 15;88(18):10421-31.

8.Wu J#, Meng Z#, Jiang M, Zhang E, Trippler M, Broering R, Bucchi A, Krux F, Dittmer U, Yang D, Roggendorf M, Gerken G, Lu M, Schlaak JF *. Toll-like receptor-induced innate immune responses in non-parenchymal liver cells are cell type-specific. Immunology. 2010 (129):363 -374 

9.Wu J#, Meng Z, Jiang M, Pei R, Trippler M, Broering R, Bucchi A, Sowa JP, Dittmer U, Yang D, Roggendorf M, Gerken G, Lu M, Schlaak JF*. HBV Suppresses Toll-like Receptor Mediated Innate Immune Responses in Murine Parenchymal and Non-parenchymal Liver Cells. Hepatology. 2009 Apr; 49(4):1132-40

10.Wu J#, Lu M, Meng Z, Trippler M, Broering R, Szczeponek A, Krux F, Dittmer U, Roggendorf M, Gerken G, Schlaak JF*. Toll-like receptor-mediated control of HBV replication by nonparenchymal liver cells in mice. Hepatology. 2007:6(46):1769-1778.

获批专利:

1.一种包含模式识别受体中TLR3配体的纳米颗粒载体及其制备方法和应用 （CN107550885A）

一种包含细胞靶向抗体及poly(I:C)的化合物及其制备方法和应用 （CN107693789A）