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姓名: 吴健
职称: 教授
单位: 复旦大学基础医学院
简历介绍:

吴健教授,获瑞典乌默尔大学医学博士学位,美国托马斯杰斐逊大学博士后。在美国加利福尼亚大学戴维斯分校医学院医学中心内科学胃肠病学及肝脏病学专科先后任助理教授、副教授及教授达15年。曾获美国肝病研究基金会授予的“肝病学者”称号。 2017年被美国肝病研究会授予该会会士(AASLD fellow)称号。先后获美国国家研究服务奖、新颖探索课题研究奖、美国癌症基金会“新颖科研奖”,先后在权威专业刊物, 如Gastroenterology、Hepatology、Journal of Hepatology、Cancer Research等发表SCI文章115余篇。总引用次数达6000余次。参与法国INSERM、英国RCUK、荷兰STW、美国、中国NSFC重点项目评审和教育部“科技进步奖”、“长江学者”、科技部重大专项评审。现受国家自然科学基金及科技部重点项目资助,主要从事代谢异常、肝脏慢性炎症与癌变及再生医学治疗研究。

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2.Wu J, Lindström P, Danielsson Å, Sehlin J. Insulin secretion in pancreatic islets from rats with cirrhosis. J Hepatol 1994; 21: 332-339

3.  Wu J, Söderbergh H, Karlsson K, Danielsson Å. Protective effect of S-adenosyl-L-methionine on bromobenzene- or D-galactosamine toxicity to isolated rat hepatocytes. Hepatology 1996; 23: 359-365.

4.  Wu J. Zern MA. Modification of liposomes for liver targeting.  J Hepatol 1996; 24:757-763

Wu J, Liu P, Zhu JL, Maddukuri S, Zern MA. Increased liver up-take of liposomes and improved targeting efficacy by labeling with asialofetuin in rodents. Hepatology 1998; 27: 772-778.

5. Wu J, Liu L, Yen YD, Catana CM, Michael H. Nantz, Zern MA. Liposome-mediated extracellular superoxide dismutase gene delivery protects against acute liver injury in mice. Hepatology 2004; 40: 195-204

6.  Zhang YH, Gu JF, Zhao LL, He LF, Qian WB, Wang JH, Wang YG, Qian QJ, Qian C, Wu J, Liu XY, Complete elimination of colorectal tumor xenograft by combined MnSOD and TRAIL gene-virotherapy. Cancer Research 2006; 66(8): 4291-4298

7.  Chen XL, Lingala S, Zern MA, Nolta JA, Wu J. Epithelial Mesenchymal Transition and Hedgehog Signaling Activation are Associated with Chemoresistance and Enhanced Metastasis of Poorly-Differentiated Hepatoma Cells. J Hepatol 2011; 55: 838-845

8. He SQ, Zhang YH, Venugopal SK, Dicus CW, Perez RV, Ramsamooj R, Nantz MH, Zern MA, Wu J. Delivery of antioxidative enzyme genes protects against ischemia/reperfusion-induced liver injury in mice. Liver Transplant 2006; 12: 1869-1879

8.  Fan Y-H, Ding J, Nguyen S, Liu X-J, Xu G, H Zhou H-Y, Duan N-N, Yang S-M, Zern MA, Wu J*. Aberrant Hedgehog Signaling is Responsible for the Highly Invasive Behavior of a Subpopulation of Hepatoma Cells. Oncogene 2016;35 (1) 116–124

10. Juan Ye, Tian-Sheng Li, Gang Xu, Yi-Ming Zhao, Ning-Ping Zhang, Jia Fan, Jian Wu*. JCAD Is Associated with the Progression of Nonalcoholic Steatohepatitis to Malignancy via Inhibition of the Kinase Activity of LATS2 in Hippo Signaling. Cancer Research 2017;77(19); 5287–300.

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