Role of A-kinase anchor protein 12 in chronic liver diseases

Haijian DONG; Hui LI; Yujing TAO; Jialing GUO; Yuru ZHONG; Zijian ZENG

doi:10.3969/j.issn.1001-5256.2023.03.037

Volume 39 Issue 3

Mar. 2023

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Article Navigation > Journal of Clinical Hepatology > 2023 > 39(3): 718-722

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Role of A-kinase anchor protein 12 in chronic liver diseases

DOI: 10.3969/j.issn.1001-5256.2023.03.037

Haijian DONG^{1, 2},
Hui LI^{1
,
,
,},
Yujing TAO^{1, 2},
Jialing GUO^{1, 2},
Yuru ZHONG^{1, 2},
Zijian ZENG^{1, 2}

1.
Central Laboratory, The Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610072, China
2.
School of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 610072, China

Research funding:

Sichuan Science and Technology Program (2020YFS0379)

More Information

Corresponding author: LI Hui, 1400124746@qq.com (ORCID: 0000-0002-5919-1396)
Received Date: 2022-07-06
Accepted Date: 2022-08-08
Published Date: 2023-03-20

Abstract

Abstract

A-kinase anchor protein 12 (AKAP12) is a scaffold protein that improves the specificity and efficiency of spatio-temporal signals by assembling intracellular signal proteins into specific complexes. In recent years, the role of AKAP12 in chronic liver diseases has attracted more and more attention. This article introduces the physiological functions of AKAP12 and reviews the role of AKAP12 in chronic liver diseases, in order to lay a foundation for the use of AKAP12 small molecule as a new therapeutic target for chronic liver diseases.
- A Kinase Anchor Proteins,
- Liver Cirrhosis,
- Non-alcoholic Fatty Liver Disease,
- Liver Diseases, Alcoholic,
- Carcinoma, Hepatocellular

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References(31)

References

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Role of A-kinase anchor protein 12 in chronic liver diseases

DOI: 10.3969/j.issn.1001-5256.2023.03.037

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