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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 39 Issue 2
Feb.  2023
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Article Contents

Research advances in immune checkpoint inhibitor-related cholangitis

DOI: 10.3969/j.issn.1001-5256.2023.02.034
Research funding:

National Natural Science Foundation of China (81901957)

More Information
  • Corresponding author: TANG Rui, tangrui_hs@163.com (ORCID: 0000-0003-3118-3842)
  • Received Date: 2022-07-03
  • Accepted Date: 2022-08-18
  • Published Date: 2023-02-20
  • Immune checkpoint inhibitors (ICIs) have ushered in a new era of tumor treatment; however, immunotherapy-related adverse events are critical issues that restrict the clinical application of ICIs and have attracted wide attention. The liver is one of the target organs that is easily affected. With the progress in research, scholars have found that besides hepatocytes, intrahepatic and extrahepatic bile ducts can also be attacked by the immune system, leading to the disease known as immune-related cholangitis. This article reviews the research advances in ICI-related cholangitis by summarizing related articles, in order to preliminarily reveal its clinical, pathological, and imaging features and provide clues for early identification, standard treatment, and subsequent research.

     

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