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ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 39 Issue 2
Feb.  2023
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Article Navigation >  Journal of Clinical Hepatology  > 2023  >  39(2): 419-423

Association between liver sinusoidal endothelial cells and liver fibrosis

DOI: 10.3969/j.issn.1001-5256.2023.02.027

  • Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai 200080, China

More Information
  • Corresponding author: CAI Xiaobo, caixiaobo1979@hotmail.com(ORCID: 0000-0002-7351-1368)
  • Received Date: 2022-08-13
  • Accepted Date: 2022-10-09
  • Published Date: 2023-02-20
    Abstract
  • Liver sinusoidal endothelial cells (LSECs) are crucial to the maintenance of hepatic homeostasis under physiologic conditions, while under the conditions of pathological liver damage, LSEC can respond to the damage by changing their structure through the process called capillarization, thereby aggravating liver damage. In addition, the interaction between LSEC and other cells in the liver plays a certain role in the development and progression of liver fibrosis, especially the interaction between LSEC and hepatic stellate cells, which are the primary effector cells of liver fibrosis. This article mainly elaborates on the role of LSEC in the development and progression of liver fibrosis during chronic liver injury.

     

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