Role of oxidative stress in acute liver injury

Yue LIAO; Yihuai HE; Yawen LUO

doi:10.3969/j.issn.1001-5256.2022.10.039

Volume 38 Issue 10

Oct. 2022

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Article Navigation > Journal of Clinical Hepatology > 2022 > 38(10): 2402-2407

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Role of oxidative stress in acute liver injury

DOI: 10.3969/j.issn.1001-5256.2022.10.039

Department of Infectious Diseases, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou 563000, China

Research funding:

National Natural Science Foundation of China (82160370);

National Natural Science Foundation of China (81560110);

Science and Technology Plan Project of Guizhou Province (Qian Ke He Ji Chu -ZK〔2022〕 Yi Ban 642)

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Corresponding author: LUO Yawen, luoyw719@163.com(ORCID: 0000-0002-8845-1265)
Received Date: 2022-02-27
Accepted Date: 2022-04-02
Published Date: 2022-10-20

Abstract

Abstract

Acute liver injury (ALI) is often caused by virus infection, alcohol, drugs, toxin, and metabolic disorder, and oxidative stress is a common pathophysiological mechanism in the development and progression of ALI and other liver diseases. Hepatocyte function is impaired after ALI, which further causes oxidative stress, and persistent or high-intensive oxidative stress may increase the risk of hepatocyte death and thus result in a series of liver diseases. Oxidative stress is mainly associated with the signaling pathways including nuclear factor erythroid 2-related factor 2 and nuclear factor-kappa B. Therefore, it is of great importance to understand the mechanism of oxidative stress in the development and progression of liver injury and related pathways. This article introduces oxidative system and antioxidative system, oxidative stress and damage factors, and oxidative stress and pathways associated with liver injury, so as to provide a reference for the selection of therapeutic targets for ALI and related clinical research.
- Acute Liver Injury,
- Oxidative Stress,
- NF-E2-Related Factor 2,
- NF-kappa B

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References(45)

References

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Role of oxidative stress in acute liver injury

DOI: 10.3969/j.issn.1001-5256.2022.10.039

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