Recent research progress and mechanisms on Traditional Chinese Medicine reversal therapy of liver fibrosis

Shiheng LIU; Suxian ZHAO; Yuguo ZHANG

doi:10.3969/j.issn.1001-5256.2022.10.033

Volume 38 Issue 10

Oct. 2022

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Article Navigation > Journal of Clinical Hepatology > 2022 > 38(10): 2373-2377

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Recent research progress and mechanisms on Traditional Chinese Medicine reversal therapy of liver fibrosis

DOI: 10.3969/j.issn.1001-5256.2022.10.033

Department of Traditional and Western Medical Hepatology, The Third Hospital of Hebei Medical University, Shijiazhuang 050000, China

Research funding:

Hebei Province Medical Technology, Tracking, and Application Project (G2018041)

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Corresponding author: ZHANG Yuguo, 15930173200@126.com(ORCID: 0000-0001-7220-2814)
Received Date: 2022-03-11
Accepted Date: 2022-04-29
Published Date: 2022-10-20

Abstract

Abstract

Liver fibrosis occurs due to damages caused by liver diseases of various etiologies and activation of hepatic stellate cells, leading to the repairing and damaging cycle by secreting a large amount of extracellular matrix and formation of fibrosis tissues in the liver. Early reversal of this process could prevent further development and progression of the disease, which may reduce incidence of the end-stage liver disease and even liver cancer. This review summarized and discussed recent advancements and mechanisms of liver sinusoidal endothelial cells, Notch signaling pathway, YAP/TAZ signaling pathway, and autophagy in regulation of liver fibrosis and then enumerated the Traditional Chinese Medicine in reversal of liver fibrosis process and the underlying molecular mechanisms. It expects to provide novel approaches and research ideas for future control of liver fibrosis using Traditional Chinese Medicine.
- Liver Cirrhosis,
- Hepatic Stellate Cells,
- Drugs, Chinese Herbal

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References(48)

References

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Recent research progress and mechanisms on Traditional Chinese Medicine reversal therapy of liver fibrosis

DOI: 10.3969/j.issn.1001-5256.2022.10.033

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Recent research progress and mechanisms on Traditional Chinese Medicine reversal therapy of liver fibrosis

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