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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 38 Issue 10
Oct.  2022
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Article Contents

Role of inflammation in hepatic fibrosis

DOI: 10.3969/j.issn.1001-5256.2022.10.032
Research funding:

Special Key Project of Chongqing Technology Innovation and Application Development (cstc2019jscx-dxwtBX0023);

Major and difficult diseases (liver fibrosis) Chinese and Western medicine clinical collaboration pilot project (Medical Administration Department, State Administration of Traditional Chinese Medicine [2018] No. 3);

Chongqing Talents · Innovation and Entrepreneurship Leading Talent Project (CQYC202003071);

Sponsored by Natural Science Foundation of Chongqing, China (cstc2020jcyj-msxmX0630);

Chongqing Medical Scientific Research Project (Joint project of Chongqing Health Commission and Science and Technology Bureau) (2019ZY3202)

More Information
  • Corresponding author: RAO Chunyan, chunyanrao@126.com(ORCID: 0000-0002-3586-9369)
  • Received Date: 2021-08-29
  • Accepted Date: 2021-10-18
  • Published Date: 2022-10-20
  • Inflammation caused by chronic liver is primarily responsible for the occurrence and pathological progression of liver fibrosis. In the process of liver fibrosis, a large number of activated inflammatory signals promote the transformation of hepatic stellate cells (HSC) into myofibroblasts (MF), which eventually leads to the massive secretion and deposition of extracellular matrix (ECM) and the formation of scar tissue in the liver. To provide literature references for clinical diagnosis and treatment, this paper reviews the roles of HSC, Kupffer cells (KC), inflammasomes and inflammatory signaling in liver fibrosis.

     

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