The discussion on the Genetically Modified Pigs for the treatment of acute liver failure

Guoli Huai; Jiaxiang Du; Dengke Pan

doi:10.3969/j.issn.1001-5256.2022.10.004

Volume 38 Issue 10

Oct. 2022

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Article Navigation > Journal of Clinical Hepatology > 2022 > 38(10): 2214-2218

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The discussion on the Genetically Modified Pigs for the treatment of acute liver failure

DOI: 10.3969/j.issn.1001-5256.2022.10.004

1.
Affiliated Hospital of University of Electronic Science and Technology of China, Sichuan Academy of Medical Sciences, Sichuan Provincial People's Hospital, Sichuan Key Laboratory of Clinical Immunological Translational Medicine, Chengdu 610072, China
2.
Chengdu Sino-Clone Organ Biotechnology, Co., Ltd., Chengdu 610094, China

Research funding:

Sichuan Science and Technology Program (Key R & D Project) (2021YFS0008)

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Corresponding author: PAN Dengke, pandengke2002@163.com(ORCID: 0000-0002-7994-1465)
Received Date: 2020-07-30
Accepted Date: 2020-08-31
Published Date: 2022-10-20

Abstract

Abstract

Liver transplants are in huge demand in China, but facing the problem of extreme shortage of donor organs. Xenogeneic (pig) liver transplantation may be a potential way to alleviate the shortage of donors. The liver is a detoxifying organ with synthetic functions, and when genetically modified pigs are used as donors, it faces the dual problem of overcoming immune rejection and resolving physiological function mismatches. Therefore, suppressing the innate immune response can better alleviate the immune rejection of xenotransplantation. In addition, the use of chimeras of humanized cell livers may resolve the problem of physiological function mismatch. Moreover, with the development of gene editing technology, it has become possible to obtain multiple gene edited pigs and chimeras. Therefore, exploring and researching from these two aspects will hopefully solve the current problems of liver xenotransplantation and promote the further development of the field of liver xenotransplantation.
- Liver Transplantation,
- Gene Editing,
- Chimera,
- Swine

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References(41)

References

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The discussion on the Genetically Modified Pigs for the treatment of acute liver failure

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