Acute humoral rejection in liver xenotransplantation

Zhongqiang ZHANG; Shuozhou LIANG; Zhongzhou SI; Haizhi QI

doi:10.3969/j.issn.1001-5256.2022.10.003

Volume 38 Issue 10

Oct. 2022

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Article Navigation > Journal of Clinical Hepatology > 2022 > 38(10): 2210-2213

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Acute humoral rejection in liver xenotransplantation

DOI: 10.3969/j.issn.1001-5256.2022.10.003

Zhongqiang ZHANG^{1, 2},
Shuozhou LIANG^{1, 2},
Zhongzhou SI^{1, 2
,
,
,},
Haizhi QI^{1, 2}

1.
Department of Liver Transplantation, The Second Xiangya Hospital of Central South University, Changsha 410011, China
2.
Transplant Medicine Research Center, The Second Xiangya Hospital of Central South University, Changsha 410011, China

Research funding:

Hunan Provincial Key Research Project (2021DK2002)

More Information

Corresponding author: SI Zhongzhou, zhongzsi@csu.edu.cn(ORCID: 0000-0022-8875-9651)
Received Date: 2020-07-30
Accepted Date: 2020-08-31
Published Date: 2022-10-20

Abstract

Abstract

Liver transplantation is a curable therapy to save the life of patients with end-stage liver diseases of different causes. The serious shortage of liver donors led to the death of a large number of patients with end-stage liver disease. Genetic-engineered pigs used for xenotransplantation are one of the potential solutions to alleviate the liver donor shortage, but currently clinical application of such xenogeneic liver grafts is hindered by acute rejection, thrombocytopenia, and coagulation dysfunctions in patients. The development of genetic-engineering technology and the application of new immunosuppressants have controlled the acute rejection of liver xenotransplantation to some extent. However, acute humoral rejection may become another major issue for the long-term graft failure. This review summarized and discussed the potential and underlying mechanisms and preventive measures of acute humoral rejection in liver xenotransplantation.
- Liver Transplantation,
- Transplantation, Heterologous,
- Animals, Genetically Modified,
- Graft Rejection

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References

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Acute humoral rejection in liver xenotransplantation

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