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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 38 Issue 10
Oct.  2022
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Article Navigation >  Journal of Clinical Hepatology  > 2022  >  38(10): 2201-2205

Development and progress of liver xenotransplantation: A potential breakthrough for current shortage of donor liver

DOI: 10.3969/j.issn.1001-5256.2022.10.001

  • Department of Hepato-Biliary Surgery and Army Institute of Organ Transplantation, Xijing Hospital, Air Force Military Medical University, Xi'an 710032, China

Research funding:

National Natural Science Foundation of China (82070681);

National Natural Science Foundation of China (82170667);

National Natural Science Foundation of China (82070671);

National Natural Science Foundation of China (81970566);

Shaanxi Natural Science Basic Research Project (2022JM-537);

Xijing Hospital Discipline Assistance Program Supporting Project (XJZT21CM14);

Medical Research Project (AKJ19J001);

Medical Research Project (18CXZ014)

More Information
  • Corresponding author: DOU Kefeng, doukef@fmmu.edu.cn(ORCID: 0000-0002-8857-5663)
  • Received Date: 2022-08-01
  • Accepted Date: 2022-08-31
  • Published Date: 2022-10-20
    Abstract
  • The donor liver shortage is the bottles-neck limitation for clinical liver transplantation to save patients' life. Liver transplantation is a treatment option for end-stage liver diseases, like Cirrhosis and hepatocellular carcinoma, and acute liver failure; however, due to availability of donor liver, lots of patients never received such treatment option and passed way. Most recently, non-human primates after a liver transplantation with GTKO pigs survived for nearly 1 month indicates a promise of clinical use of liver xenotransplantation and could offer "a bridge transplantation" for fulminant liver failure patients. This review discussed and summarized the advancement and progress in the field, i.e., history of liver xenotransplantation research, model animals, clinical selection criteria, and future research directions and clinical trials.

     

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    • References(20)
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