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ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 38 Issue 9
Sep.  2022
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Article Navigation >  Journal of Clinical Hepatology  > 2022  >  38(9): 2172-2176

Role of Takeda G protein-coupled receptor-5 in non-viral liver diseases

DOI: 10.3969/j.issn.1001-5256.2022.09.043
  • 1.

    Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine; Institute of Liver Diseases, Shanghai University of Traditional Chinese Medicine; Key Laboratory of Liver and Kidney Diseases, Ministry of Education; Shanghai Key Laboratory of Traditional Chinese Clinical Medicine, Shanghai 201203, China

  • 2.

    Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai Frontiers Science Center of TCM Chemical Biology, Shanghai 201203, China

Research funding:

Key Program of National Natural Science Foundation of China (82130120);

National Natural Science Foundation of China (81973613);

Shanghai Rising-Star Program (19QA1408900)

More Information
  • Corresponding author: LIU Ping, liuliver@vip.sina.com(ORCID: 0000-0002-6152-4508); CHEN Jiamei, cjm0102@126.com(ORCID: 0000-0001-9808-9610)
  • Received Date: 2022-01-31
  • Accepted Date: 2022-03-05
  • Published Date: 2022-09-20
    Abstract
  • Non-viral liver diseases mainly include nonalcoholic fatty liver disease, alcoholic liver disease, autoimmune liver disease, and cholestatic liver disease, and the prevalence rate of non-viral liver diseases tends to increase in recent years. Takeda G protein-coupled receptor-5 (TGR5) belongs to the G protein-coupled receptor superfamily and is activated by primary and secondary bile acids. TGR5 plays an important regulatory role in bile acid homeostasis, basal metabolism, energy balance, and alleviation of inflammatory response and is a potential therapeutic target for many diseases. An increasing number of evidence has shown that TGR5 exerts a protective effect on the liver by improving bile acid and glycolipid metabolism in liver, alleviating liver inflammation, and reducing liver steatosis. This article reviews the recent advances in the basic research on TGR5 in the field of non-viral liver diseases, so as to facilitate the development of the research on TGR5.

     

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