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ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 38 Issue 2
Feb.  2022
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Article Navigation >  Journal of Clinical Hepatology  > 2022  >  38(2): 457-460

Role of liver-resident natural killer cells in the development and progression of hepatocellular carcinoma

DOI: 10.3969/j.issn.1001-5256.2022.02.041

  • Department of General Surgery, Shengjing Hospital of China Medical University, Shenyang 110004, China

Research funding:

The Natural Science Fund of Liaoning Province (20180551193);

The Natural Science Fund of Liaoning Province (2020-MS-181);

The 345 Talent Project of Shengjing Hospital (40B)

More Information
  • Corresponding author: XU Feng, xufengsjh@126.com
  • Received Date: 2021-06-20
  • Accepted Date: 2021-07-21
  • Published Date: 2022-02-20
    Abstract
  • Liver-resident natural killer (LrNK) cells, as a type of newly discovered tissue-resident natural killer cells, have a strong immune killing function. During the development and progression of hepatocellular carcinoma (HCC), the function of LrNK cells is impaired and such cells may promote the progression of HCC by upregulating the expression of related immune checkpoints. Based on the latest research, this article reviews the immune function of LrNK cells and their role in the development and progression of HCC, in order to explore the application prospect of these cells in HCC immunotherapy.

     

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