Association between the Wnt signaling pathway and hepatic fibrosis

Qin FAN; Hongjun LI; Xiaoxia LI; Yin YANG; Haiyan CHEN; Jiamao CHENG

doi:10.3969/j.issn.1001-5256.2022.02.038

Volume 38 Issue 2

Feb. 2022

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Article Navigation > Journal of Clinical Hepatology > 2022 > 38(2): 443-447

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Association between the Wnt signaling pathway and hepatic fibrosis

DOI: 10.3969/j.issn.1001-5256.2022.02.038

Qin FAN¹,
Hongjun LI²,
Xiaoxia LI²,
Yin YANG²,
Haiyan CHEN^{2
,
,},
Jiamao CHENG^{1
,
,}

1.
Department of Human Anatomy, Basic Medical College of Dali University, Dali, Yunnan 671000, China
2.
Department of Ultrasound, School of Clinical Medicine, Dali University; Department of Ultrasound, The Fourth People's Hospital of Yunnan Province, Dali, Yunnan 671000, China

Research funding:

General Project of Special Joint Fund for the Basic Research of Local Undergraduate Colleges and Universities in Yunnan Province in 2021 (202101BA070001-101);

The 2022 Scientific Research Fund of the Education Department of Yunnan Province (2022Y809);

The 2021 Scientific Research Fund of the Education Department of Yunnan Province (2021J0382);

The 2017 Joint University Fund of Natural Science Foundation of Yunnan Province (2017FH001-076);

Project of Li Yunqing Expert Workstation of Yunnan Province (202005AF150014);

Innovation Team of Neurobiology of Dali University (ZKLX2019108)

More Information

Corresponding author: CHEN Haiyan, 316573230@qq.com; CHENG Jiamao, chjmao@163.com
Received Date: 2021-07-05
Accepted Date: 2021-08-11
Published Date: 2022-02-20

Abstract

Abstract

Hepatic fibrosis (HF) is a self-healing pathological process after all kinds of chronic liver injuries and can cause diseases such as liver cirrhosis and liver cancer. The Wnt signaling pathway is highly conserved in species evolution and widely exists in invertebrates and vertebrates, and many studies have confirmed that the Wnt signaling pathway is closely associated with the development and progression of HF. This article reviews the mechanisms of the classical and non-classical Wnt signaling pathways in regulating hepatic stellate cells, hepatic macrophages, and hepatic progenitor cells, so as to provide new ideas for subsequent studies on the mechanism of the Wnt signaling pathway in regulating HF and further exploration of therapeutic targets that can reverse HF.
- Liver Cirrhosis,
- Wnt Signaling Pathway,
- Hepatic Stellate Cells,
- Kupffer Cells,
- Stem Cells

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References(51)

References

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Association between the Wnt signaling pathway and hepatic fibrosis

DOI: 10.3969/j.issn.1001-5256.2022.02.038

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Association between the Wnt signaling pathway and hepatic fibrosis

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