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Volume 37 Issue 12
Dec.  2021
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Article Navigation >  Journal of Clinical Hepatology  > 2021  >  37(12): 2976-2980

Mechanism of pyroptosis and its role in the development and progression of liver diseases

DOI: 10.3969/j.issn.1001-5256.2021.12.051

  • Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medicine Science & Peking Union Medical College, Tianjin 300192, China

Research funding:

National Natural Science Foundation of China (81972975)

  • Received Date: 2021-04-16
  • Accepted Date: 2021-06-24
  • Published Date: 2021-12-20
    Abstract
  • Pyroptosis is a pattern of cell death to eliminate endogenous and exogenous harmful stimuli. GSDMD and GSDME, members of the Gasdermin protein family, are the main executors of pyroptosis, and after being cut by activated caspases, they can induce pyroptosis by perforating the cell membrane, and causing the release of intracellular inflammatory factors such as IL-18 and IL-1β. Recent studies have found that pyroptosis is involved and plays a "double-edged sword" role in the development and progression of liver diseases. This article elaborates on the molecular mechanism of pyroptosis and the research advances in the role of pyroptosis in the development and progression of liver diseases, so as to provide new targets and ideas for the prevention and treatment of liver diseases.

     

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