Research advances in drug-induced vanishing bile duct syndrome

Shanshan XU; Lixia QIU; Jingjing SONG; Jing ZHANG

doi:10.3969/j.issn.1001-5256.2021.08.051

Volume 37 Issue 8

Aug. 2021

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Article Navigation > Journal of Clinical Hepatology > 2021 > 37(8): 1979-1982

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Research advances in drug-induced vanishing bile duct syndrome

DOI: 10.3969/j.issn.1001-5256.2021.08.051

1.
Third Department of Liver Disease Center, Beijing YouAn Hospital, Capital Medical University, Beijing 100069, China
2.
Department of Infectious Liver Diseases, Peking University International Hospital, Beijing 102206, China

Research funding:

The Scientific Research Project of YouAn Liver Disease AIDS Fund (YNKTTS20180115)

Received Date: 2020-12-21
Accepted Date: 2021-01-19
Published Date: 2021-08-20

Abstract

Abstract

Current evidence shows that drug-induced liver injury has become one of the common causes of acute liver injury in clinical practice. Vanishing bile duct syndrome (VBDS) refers to a syndrome of focal or diffuse disappearance of intrahepatic bile ducts characterized by cholestasis, and drug-induced VBDS (D-VBDS) is one of the important causes of this disease. Most patients with D-VBDS have a good prognosis, but some patients may progress to liver cirrhosis and liver failure. By reviewing the advances in the clinical diagnosis and treatment of D-VBDS, this article points out the difficulty in the diagnosis of D-VBDS, the limited treatment methods for this disease, and poor prognosis in some patients. Therefore, drugs should be used with caution in clinical practice to reduce the incidence and mortality rates of D-VBDS.
- Vanishing Bile Duct Syndrome,
- Chemical and Drug Induced Liver Injury,
- Pathology, Clinical,
- Therapeutics

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References(37)

References

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沈阳化工大学材料科学与工程学院沈阳 110142

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Research advances in drug-induced vanishing bile duct syndrome

DOI: 10.3969/j.issn.1001-5256.2021.08.051

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