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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 37 Issue 8
Aug.  2021
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Article Navigation >  Journal of Clinical Hepatology  > 2021  >  37(8): 1943-1947

Research advances in alcoholic liver disease with sarcopenia

DOI: 10.3969/j.issn.1001-5256.2021.08.043
  • 1.

    Department of Pharmacy, 960 Hospital of PLA Joint Logistics Support Force, Jinan 250031, China

  • 2.

    Liver Disease Center, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China

  • 3.

    Liver Disease Center, Beijing Ditan Teaching Hospital, Peking University Health Science Center, Beijing 100015, China

  • 4.

    Second Department of Hepatology, The Forth People's Hospital of Qinghai Province, Xining 810000, China

Research funding:

National Science and Technology Major Project (2017ZX10202202);

National Science and Technology Major Project (2018ZX10715-005);

Qinghai Provincial High-end and Innovative 1000 Talents Plan (2019-24);

Chinese Foundation for Hepatitis Prevention and Control-TianQing Liver Disease Research Fund (TQGB20210050)

  • Received Date: 2021-01-21
  • Accepted Date: 2021-02-05
  • Published Date: 2021-08-20
    Abstract
  • Alcoholic liver disease (ALD) is one of the most common liver diseases affecting the health of the Chinese people, and about 60% of ALD patients suffer from sarcopenia. Anorexia, inadequate intake of nutrients, disorder of digestion and absorption, reduction in physical activity, and increase in blood ammonia are common causes of sarcopenia in patients with ALD; besides, alcohol and its metabolites may affect the synthesis of skeletal muscle protein and promote the autophagy of skeletal muscle cells through multiple signaling pathways. Patients with ALD and sarcopenia tend to have increased risks of poor prognosis, such as hepatic encephalopathy and liver cancer. Further studies are needed to investigate the interventions for patients with ALD and sarcopenia.

     

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