Paving the way to improve clinical management of acute-on-chronic liver failure using international criteria

Zhujun CAO; Chenxi ZHANG; Qing XIE

doi:10.3969/j.issn.1001-5256.2021.04.001

Volume 37 Issue 4

Apr. 2021

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Article Navigation > Journal of Clinical Hepatology > 2021 > 37(4): 745-751

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Paving the way to improve clinical management of acute-on-chronic liver failure using international criteria

DOI: 10.3969/j.issn.1001-5256.2021.04.001

Department of Infectious Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China

Research funding:

(82000588);

(81900567);

(2017ZX10203201-008);

(2018ZX09201016-003-001);

(2017ZX10202202-005-004);

(TQGB20210021);

;

(shslczdzk01103)

Received Date: 2021-02-28
Accepted Date: 2021-03-05
Published Date: 2021-04-20

Abstract

Abstract

Acute-on-chronic liver failure (ACLF) is a clinical disease significantly different from acute liver failure and acute decompensation of simple liver cirrhosis, and it may have acute progression to liver failure and failure of other organs. ACLF has a high short-term mortality rate and has become a disease burden worldwide. In recent years, several international associations for the study of the liver have proposed different diagnostic criteria for ACLF and published their respective consensus or review on the diagnosis and treatment of ACLF, and there are still great differences in the comprehension of chronic liver diseases, acute injury, and organ failure. At present, there are still limited data for the key links of ACLF management in China, such as liver transplantation, intensive care unit, and palliative care, and in the context of no consensus on the diagnosis of ACLF around the world, it is necessary to further strengthen the application of existing international criteria and evidence and the accumulation of evidence-based data in China.
- Acute-On-Chronic Liver Failure,
- Liver Cirrhosis,
- Diagnosis,
- Therapeutics,
- Clinical Governance

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References(39)

References

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Paving the way to improve clinical management of acute-on-chronic liver failure using international criteria

DOI: 10.3969/j.issn.1001-5256.2021.04.001

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Paving the way to improve clinical management of acute-on-chronic liver failure using international criteria

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