中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 37 Issue 3
Mar.  2021
Turn off MathJax
Article Contents

Research advances in dietary intervention in the treatment of metabolic associated fatty liver disease

DOI: 10.3969/j.issn.1001-5256.2021.03.042
  • Received Date: 2020-08-17
  • Accepted Date: 2020-10-22
  • Published Date: 2021-03-20
  • Poor dietary habit is an important cause of the global prevalence of metabolic associated fatty liver disease (MAFLD), and the adjustment of dietary pattern is the cornerstone of MAFLD management. In recent years, a large number of new dietary intervention methods have been proposed and applied in the treatment of MAFLD, including calorie restrict diet, low-carbohydrate diet, low-glycemic index diet, low free sugar diet, intermittent fasting pattern, high protein diet, and Mediterranean diet, and these new methods have different effects in clinical practice. This article introduces the treatment concepts and practical methods of these new dietary treatment strategies and the evidence of their benefits in the treatment of MAFLD in China and globally, so as to provide a new perspective for clinicians to guide patients to achieve individualized nutritional therapy.

     

  • loading
  • [1]
    ESLAM M, SARIN SK, WONG VW, et al. The Asian Pacific Association for the Study of the Liver clinical practice guidelines for the diagnosis and management of metabolic associated fatty liver disease[J]. Hepatol Int, 2020. [Online ahead of print] DOI: 10.1007%2Fs12072-020-10094-2
    [2]
    ZHANG B, ZHAI FY, DU SF, et al. The China health and nutrition survey, 1989-2011[J]. Obes Rev, 2014, 15(Suppl 1): 2-7.
    [3]
    YOO ER, KIM D, VAZQUEZ-MONTESINO LM, et al. Diet quality and its association with nonalcoholic fatty liver disease and all-cause and cause-specific mortality[J]. Liver Int, 2020, 40(4): 815-824. DOI: 10.1111/liv.14374
    [4]
    ALFERINK LJ, KIEFTE-DE JONG JC, ERLER NS, et al. Association of dietary macronutrient composition and non-alcoholic fatty liver disease in an ageing population: The rotterdam study[J]. Gut, 2019, 68(6): 1088-1098. DOI: 10.1136/gutjnl-2017-315940
    [5]
    CHITTURI S, WONG VW, CHAN WK, et al. The Asia-Pacific Working Party on non-alcoholic fatty liver disease guidelines 2017-part 2: Management and special groups[J]. J Gastroenterol Hepatol, 2018, 33(1): 86-98. DOI: 10.1111/jgh.13856
    [6]
    National Workshop on Fatty Liver and Alcoholic Liver Disease, Chinese Society of Hepatology, Chinese Medical Association; Fatty Liver Expert Committee, Chinese Medical Doctor Association. Guidelines of prevention and treatment for nonalcoholic fatty liver disease: A 2018 update[J]. J Clin Hepatol, 2018, 34(5): 947-957. DOI: 10.3969/j.issn.1001-5256.2018.05.007

    中华医学会肝病学分会脂肪肝和酒精性肝病学组, 中国医师协会脂肪性肝病专家委员会. 非酒精性脂肪性肝病防治指南(2018年更新版)[J]. 临床肝胆病杂志, 2018, 34(5): 947-957. DOI: 10.3969/j.issn.1001-5256.2018.05.007
    [7]
    SAEED N, NADEAU B, SHANNON C, et al. Evaluation of dietary approaches for the treatment of non-alcoholic fatty liver disease: A systematic review[J]. Nutrients, 2019, 11(12): 3064. DOI: 10.3390/nu11123064
    [8]
    ASGHARI S, ASGHARI-JAFARABADI M, SOMI MH, et al. Comparison of calorie-restricted diet and resveratrol supplementation on anthropometric indices, metabolic parameters, and serum sirtuin-1 levels in patients with nonalcoholic fatty liver disease: A randomized controlled clinical trial[J]. J Am Coll Nutr, 2018, 37(3): 223-233. DOI: 10.1080/07315724.2017.1392264
    [9]
    YE J, WU Y, LI F, et al. Effect of orlistat on liver fat content in patients with nonalcoholic fatty liver disease with obesity: Assessment using magnetic resonance imaging-derived proton density fat fraction[J]. Therap Adv Gastroenterol, 2019, 12: 1756284819879047. http://www.ncbi.nlm.nih.gov/pubmed/31632457
    [10]
    MARDINOGLU A, WU H, BJORNSON E, et al. An integrated understanding of the rapid metabolic benefits of a carbohydrate-restricted diet on hepatic steatosis in humans[J]. Cell Metab, 2018, 27(3): 559-571. DOI: 10.1016/j.cmet.2018.01.005
    [11]
    AHN J, JUN DW, LEE HY, et al. Critical appraisal for low-carbohydrate diet in nonalcoholic fatty liver disease: Review and meta-analyses[J]. Clin Nutr, 2019, 38(5): 2023-2030. DOI: 10.1016/j.clnu.2018.09.022
    [12]
    PARKER A, KIM Y. The effect of low glycemic index and glycemic load diets on hepatic fat mass, insulin resistance, and blood lipid panels in individuals with nonalcoholic fatty liver disease[J]. Metab Syndr Relat Disord, 2019, 17(8): 389-396. DOI: 10.1089/met.2019.0038
    [13]
    WONG VW, CHAN RS, WONG GL, et al. Community-based lifestyle modification programme for non-alcoholic fatty liver disease: A randomized controlled trial[J]. J Hepatol, 2013, 59(3): 536-542. DOI: 10.1016/j.jhep.2013.04.013
    [14]
    HERFORTH A, ARIMOND M, ÁLVAREZ-SÁNCHEZ C, et al. A global review of food-based dietary guidelines[J]. Adv Nutr, 2019, 10(4): 590-605. DOI: 10.1093/advances/nmy130
    [15]
    SSCHWIMMER JB, UGALDE-NICALO P, WELSH JA, et al. Effect of a low free sugar diet vs usual diet on nonalcoholic fatty liver disease in adolescent boys: A randomized clinical trial[J]. JAMA, 2019, 321(3): 256-265. DOI: 10.1001/jama.2018.20579
    [16]
    China Expert Consensus Committee on Medical Nutrition Therapy for Overweight and Obesity. China expert consensus on medical nutrition therapy for overweight and obesity (2016)[J]. Chin J Diabetes, 2016, 8(9): 525-540. https://www.cnki.com.cn/Article/CJFDTOTAL-TNBL201610004.htm

    中国超重肥胖医学营养治疗专家共识编写委员会. 中国超重/肥胖医学营养治疗专家共识(2016年版)[J]. 中华糖尿病杂志, 2016, 8(9): 525-540. https://www.cnki.com.cn/Article/CJFDTOTAL-TNBL201610004.htm
    [17]
    WILKINSON MJ, MANOOGIAN E, ZADOURIAN A, et al. Ten-hour time-restricted eating reduces weight, blood pressure, and atherogenic lipids in patients with metabolic syndrome[J]. Cell Metab, 2020, 31(1): 92-104. DOI: 10.1016/j.cmet.2019.11.004
    [18]
    CAI H, QIN YL, SHI ZY, et al. Effects of alternate-day fasting on body weight and dyslipidaemia in patients with non-alcoholic fatty liver disease: A randomised controlled trial[J]. BMC Gastroenterol, 2019, 19(1): 219. DOI: 10.1186/s12876-019-1132-8
    [19]
    de CHIARA F, URETA CHECCLLO C, RAMÓN AZCÓN J. High protein diet and metabolic plasticity in non-alcoholic fatty liver disease: Myths and truths[J]. Nutrients, 2019, 11(12): 2985. DOI: 10.3390/nu11122985
    [20]
    MARKOVA M, PIVOVAROVA O, HORNEMANN S, et al. Isocaloric diets high in animal or plant protein reduce liver fat and inflammation in individuals with type 2 diabetes[J]. Gastroenterology, 2017, 152(3): 571-585. DOI: 10.1053/j.gastro.2016.10.007
    [21]
    SKYTTE MJ, SAMKANI A, PETERSEN AD, et al. A carbohydrate-reduced high-protein diet improves HbA1c and liver fat content in weight stable participants with type 2 diabetes: A randomised controlled trial[J]. Diabetologia, 2019, 62(11): 2066-2078. DOI: 10.1007/s00125-019-4956-4
    [22]
    O'KEEFE SJ. Diet, microorganisms and their metabolites, and colon cancer[J]. Nat Rev Gastroenterol Hepatol, 2016, 13(12): 691-706. DOI: 10.1038/nrgastro.2016.165
    [23]
    PLAZ TORRES MC, AGHEMO A, LLEO A, et al. Mediterranean diet and NAFLD: What we know and questions that still need to be answered[J]. Nutrients, 2019, 11(12): 2971. DOI: 10.3390/nu11122971
    [24]
    European Association for the Study of the Liver (EASL); European Association for the Study of Diabetes (EASD); European Association for the Study of Obesity (EASO). EASL-EASD-EASO Clinical Practice Guidelines for the management of non-alcoholic fatty liver disease[J]. J Hepatol, 2016, 64(6): 1388-1402. DOI: 10.1016/j.jhep.2015.11.004
    [25]
    GEPNER Y, SHELEF I, KOMY O, et al. The beneficial effects of Mediterranean diet over low-fat diet may be mediated by decreasing hepatic fat content[J]. J Hepatol, 2019, 71(2): 379-388. DOI: 10.1016/j.jhep.2019.04.013
    [26]
    XIAO ML, LIN JS, LI YH, et al. Adherence to the dietary approaches to stop hypertension (DASH) diet is associated with lower presence of non-alcoholic fatty liver disease in middle-aged and elderly adults[J]. Public Health Nutr, 2020, 23(4): 674-682. DOI: 10.1017/S1368980019002568
    [27]
    RAZAVI ZADE M, TELKABADI MH, BAHMANI F, et al. The effects of DASH diet on weight loss and metabolic status in adults with non-alcoholic fatty liver disease: A randomized clinical trial[J]. Liver Int, 2016, 36(4): 563-571. DOI: 10.1111/liv.12990
    [28]
    ROMERO-GÓMEZ M, ZELBER-SAGI S, TRENELL M. Treatment of NAFLD with diet, physical activity and exercise[J]. J Hepatol, 2017, 67(4): 829-846. DOI: 10.1016/j.jhep.2017.05.016
    [29]
    CHAN D, SO HK, HUI S, et al. Dietitian-led lifestyle modification programme for obese Chinese adolescents with non-alcoholic fatty liver disease: A randomized controlled study[J]. Int J Obes (Lond), 2018, 42(9): 1680-1690. DOI: 10.1038/s41366-018-0010-8
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Article Metrics

    Article views (554) PDF downloads(91) Cited by()
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return