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Volume 37 Issue 3
Mar.  2021
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Article Navigation >  Journal of Clinical Hepatology  > 2021  >  37(3): 695-698

Role of circular RNA in the development and progression of hepatocellular carcinoma

DOI: 10.3969/j.issn.1001-5256.2021.03.039

  • Department of Clinical Laboratory, Renmin Hospital of Wuhan University, Wuhan 430060, China

  • Received Date: 2020-08-14
  • Accepted Date: 2020-09-14
  • Published Date: 2021-03-20
    Abstract
  • Hepatocellular carcinoma (HCC) is one of the most common malignant tumors in the world, and the study on the regulatory mechanisms of the invasion and migration of HCC is of great significance to clinical diagnosis and treatment. Circular RNA (circRNA), as an important member of the non-coding RNA family, plays the role of microRNA (miRNA) sponge in hepatocytes due to its highly stable circular structure. It also plays an important role in HCC progression by regulating miRNA or promoting the expression of target genes through the competitive endogenous RNA mechanism. This article explores the mechanism of action of circRNA in the pathogenesis of HCC, so as to help with the screening for diagnostic markers of HCC and the development of effective therapeutic targets for HCC.

     

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