Relationship between vitamin D level in children and adolescents with nonalcoholic fatty liver disease: A Meta-analysis

Tingpeng HU; Sudan TANG; Zebo YU

doi:10.3969/j.issn.1001-5256.2021.03.024

Volume 37 Issue 3

Mar. 2021

Turn off MathJax

Article Contents

Article Navigation > Journal of Clinical Hepatology > 2021 > 37(3): 627-631

PDF( 2011 KB)

Relationship between vitamin D level in children and adolescents with nonalcoholic fatty liver disease: A Meta-analysis

DOI: 10.3969/j.issn.1001-5256.2021.03.024

1.
Department of Blood Transfusion, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400000, China
2.
Department of radiology, Yongchuan Hospital Affiliated to Chongqing Medical University, Chongqing 402100, China

Received Date: 2020-07-30
Accepted Date: 2020-08-31
Published Date: 2021-03-20

Abstract

Abstract

Objective To systematically evaluate the association between vitamin D level and nonalcoholic fatty liver disease (NAFLD) in children and adolescents. Methods Related English and Chinese databases, including PubMed, Cochrane Library, Embase, CNKI, CBM, Wanfang Data, and VIP, were searched for studies on the association between vitamin D level and NAFLD in children and adolescents published up to August 2020. Newcastle-Ottawa Scale (NOS) was used to evaluate quality of studies, and RevMan 5.3 software was used for data analysis. Results A total of 10 articles were included in the meta-analysis, with 622 patients in the NAFLD group and 1608 in the healthy control group. All 10 articles had an NOS score of ≥6. A pooled analysis of the 10 articles was performed using a random effects model (I²=97%, P < 0.05). The NAFLD group had a significantly lower serum 25(OH) D level than the healthy control group (standardized mean difference=-1.40, 95% confidence interval: -2.07 to -0.72). Conclusion There is a significant reduction in serum vitamin D level in children and adolescents with NAFLD, which may be associated with the progression and severity of NAFLD.
- Non-Alcoholic Fatty Liver Disease,
- Vitamin D,
- Meta-Analysis As Topic

FullText(HTML)

References(31)

References

[1]	SERRADILLA MARTÍN M, OLIVER GUILLÉN JR, PALOMARES CANO A, et al. Metabolic syndrome, non-alcoholic fatty liver disease and hepatocarcinoma[J]. Rev Esp Enferm Dig, 2020, 112(2): 133-138.
[2]	XIAO WS, LE YY, ZENG SL, et al. Research advances in the pathogenesis of nonalcoholic fatty liver disease[J]. J Clin Hepatol, 2020, 36(8): 1874-1879. (in Chinese) DOI: 10.3969/j.issn.1001-5256.2020.08.043 肖伟松, 乐滢玉, 曾胜澜, 等. 非酒精性脂肪性肝病的发病机制研究进展[J]. 临床肝胆病杂志, 2020, 36(8): 1874-1879. DOI: 10.3969/j.issn.1001-5256.2020.08.043
[3]	WU J, SUN M. Diagnosis and treatment of non-alcoholic fatty liver disease in children[J]. J Appl Clin Pediatr, 2019, 34(19): 1441-1444. (in Chinese) https://www.cnki.com.cn/Article/CJFDTOTAL-CRBX201902018.htm 吴捷, 孙梅. 儿童非酒精性脂肪性肝病的诊治进展[J]. 中华实用儿科临床杂志, 2019, 34(19): 1441-1444. https://www.cnki.com.cn/Article/CJFDTOTAL-CRBX201902018.htm
[4]	TORUN E, GÖNÜLLÜ E, OZGEN IT, et al. Vitamin d deficiency and insufficiency in obese children and adolescents and its relationship with insulin resistance[J]. Int J Endocrinol, 2013, 2013: 631845. http://pubmedcentralcanada.ca/pmcc/articles/PMC3623428/?report=abstract
[5]	MANSON JE, COOK NR, LEE IM, et al. Vitamin D supplements and prevention of cancer and cardiovascular disease[J]. N Engl J Med, 2019, 380(1): 33-44. DOI: 10.1056/NEJMoa1809944
[6]	CHAROENNGAM N, HOLICK MF. Immunologic effects of vitamin D on human health and disease[J]. Nutrients, 2020, 12(7): 2097. DOI: 10.3390/nu12072097
[7]	BOREL P, CAILLAUD D, CANO NJ. Vitamin D bioavailability: State of the art[J]. Crit Rev Food Sci Nutr, 2015, 55(9): 1193-1205. DOI: 10.1080/10408398.2012.688897
[8]	GULSETH HL, GJELSTAD IM, BIRKELAND KI, et al. Vitamin D and the metabolic syndrome[J]. Curr Vasc Pharmacol, 2013, 11(6): 968-984. DOI: 10.2174/15701611113119990169
[9]	LU Z, PAN X, HU Y, et al. Serum vitamin D levels are inversely related with non-alcoholic fatty liver disease independent of visceral obesity in Chinese postmenopausal women[J]. Clin Exp Pharmacol Physiol, 2015, 42(2): 139-145. DOI: 10.1111/1440-1681.12334
[10]	LIU T, XU L, CHEN FH, et al. Association of serum vitamin D level and nonalcoholic fatty liver disease: A meta-analysis[J]. Eur J Gastroenterol Hepatol, 2020, 32(2): 140-147. DOI: 10.1097/MEG.0000000000001486
[11]	GIBSON PS, QUAGLIA A, DHAWAN A, et al. Vitamin D status and associated genetic polymorphisms in a cohort of UK children with non-alcoholic fatty liver disease[J]. Pediatr Obes, 2018, 13(7): 433-441. DOI: 10.1111/ijpo.12293
[12]	SEZER OB, BULUŞ D, HIZLI Ş, et al. Low 25-hydroxyvitamin D level is not an independent risk factor for hepatosteatosis in obese children[J]. J Pediatr Endocrinol Metab, 2016, 29(7): 783-788. DOI: 10.1515/jpem-2015-0426
[13]	STANG A. Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses[J]. Eur J Epidemiol, 2010, 25(9): 603-605. DOI: 10.1007/s10654-010-9491-z
[14]	CHANG EJ, YI DY, YANG HR. Vitamin D status and bone mineral density in obese children with nonalcoholic fatty liver disease[J]. J Korean Med Sci, 2015, 30(12): 1821-1827. DOI: 10.3346/jkms.2015.30.12.1821
[15]	YILDIZ I, EROL OB, TOPRAK S, et al. Role of vitamin D in children with hepatosteatosis[J]. J Pediatr Gastroenterol Nutr, 2014, 59(1): 106-111. DOI: 10.1097/MPG.0000000000000371
[16]	PIRGON O, CEKMEZ F, BILGIN H, et al. Low 25-hydroxyvitamin D level is associated with insulin sensitivity in obese adolescents with non-alcoholic fatty liver disease[J]. Obes Res Clin Pract, 2013, 7(4): e275-283. DOI: 10.1016/j.orcp.2012.01.004
[17]	MOHAMED AHMED A, ABDEL GHANY M, ABDEL HAKEEM GL, et al. Assessment of vitamin D status in a group of Egyptian children with nonalcoholic fatty liver disease[J]. Nutr Metab (Lond), 2016, 13: 53. DOI: 10.1186/s12986-016-0112-z
[18]	MALESPIN M, SLEESMAN B, LAU A, et al. Prevalence and correlates of suspected nonalcoholic fatty liver disease in Chinese American children[J]. J Clin Gastroenterol, 2015, 49(4): 345-349. DOI: 10.1097/MCG.0000000000000121
[19]	BLACK LJ, JACOBY P, SHE PING-DELFOS WC, et al. Low serum 25-hydroxyvitamin D concentrations associate with non-alcoholic fatty liver disease in adolescents independent of adiposity[J]. J Gastroenterol Hepatol, 2014, 29(6): 1215-1222. DOI: 10.1111/jgh.12541
[20]	NOBILI V, GIORGIO V, LICCARDO D, et al. Vitamin D levels and liver histological alterations in children with nonalcoholic fatty liver disease[J]. Eur J Endocrinol, 2014, 170(4): 547-553. DOI: 10.1530/EJE-13-0609
[21]	HU Y, ZHOU Y, HE JX, et al. Effect of serum level change of 25-(OH) D3 and IL-17 in obesity children with NAFLD[J]. Chin J Health Lab Technol, 2018, 28(3): 323-325. (in Chinese) https://www.cnki.com.cn/Article/CJFDTOTAL-ZWJZ201803021.htm 胡颖, 周莹, 何继新, 等. 血清25-羟维生素D3和IL-17水平变化在肥胖儿童非酒精性脂肪肝病进展中的作用[J]. 中国卫生检验杂志, 2018, 28(3): 323-325. https://www.cnki.com.cn/Article/CJFDTOTAL-ZWJZ201803021.htm
[22]	ZHANG LH, SHAO Q, XIA ZJ. Changes of serum 25-(OH) D3 and IL-17 levels are associated with progress of nonalcoholic fatty liver disease in obese children[J]. J Prac Hepatol, 2019, 22(4): 522-525. (in Chinese) https://www.cnki.com.cn/Article/CJFDTOTAL-GBSY201904018.htm 张兰华, 邵琴, 夏振娟. 非酒精性脂肪性肝病儿童血清25-(OH)D3和IL-17水平变化初步研究[J]. 实用肝脏病杂志, 2019, 22(4): 522-525. https://www.cnki.com.cn/Article/CJFDTOTAL-GBSY201904018.htm
[23]	ZHOU XL, FU JF. Expert consensus on the diagnosis and treatment of nonalcoholic fatty liver disease in children[J]. Chin J Pract Pediatr, 2018, 33(7): 487-492. (in Chinese) https://www.cnki.com.cn/Article/CJFDTOTAL-ZSEK201807002.htm 周雪莲, 傅君芬. 儿童非酒精性脂肪肝病诊断与治疗专家共识[J]. 中国实用儿科杂志, 2018, 33(7): 487-492. https://www.cnki.com.cn/Article/CJFDTOTAL-ZSEK201807002.htm
[24]	CHALASANI N, YOUNOSSI Z, LAVINE JE, et al. The diagnosis and management of non-alcoholic fatty liver disease: Practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association[J]. Hepatology, 2012, 55(6): 2005-2023. DOI: 10.1002/hep.25762
[25]	SHAUNAK M, BYRNE CD, DAVIS N, et al. Non-alcoholic fatty liver disease and childhood obesity[J]. Arch Dis Child, 2021, 106(1): 3-8. DOI: 10.1136/archdischild-2019-318063
[26]	AQUINO S, CUNHA A, LIMA JG, et al. Effects of vitamin D supplementation on fasting glucose, dyslipidemia, blood pressure, and abdominal obesity among patients with metabolic syndrome: A protocol for systematic review and meta-analysis of randomized controlled trials[J]. Syst Rev, 2020, 9(1): 176. DOI: 10.1186/s13643-020-01433-3
[27]	GOLDNER WS, STONER JA, THOMPSON J, et al. Prevalence of vitamin D insufficiency and deficiency in morbidly obese patients: A comparison with non-obese controls[J]. Obes Surg, 2008, 18(2): 145-150. DOI: 10.1007/s11695-007-9315-8
[28]	ROSENBLUM JL, CASTRO VM, MOORE CE, et al. Calcium and vitamin D supplementation is associated with decreased abdominal visceral adipose tissue in overweight and obese adults[J]. Am J Clin Nutr, 2012, 95(1): 101-108. DOI: 10.3945/ajcn.111.019489
[29]	QU YL, WANG YC, WAN JX. Association of nonalcoholic fatty liver disease with vitamin D and bone mineral density[J]. J Clin Hepatol, 2019, 35(9): 2021-2025. (in Chinese) DOI: 10.3969/j.issn.1001-5256.2019.09.027 曲玉蕾, 王迎春, 万金鑫. 非酒精性脂肪性肝病与血清维生素D及骨密度的关系[J]. 临床肝胆病杂志, 2019, 35(9): 2021-2025. DOI: 10.3969/j.issn.1001-5256.2019.09.027
[30]	MAI XM, CHEN Y, CAMARGO CA Jr, et al. Cross-sectional and prospective cohort study of serum 25-hydroxyvitamin D level and obesity in adults: the HUNT study[J]. Am J Epidemiol, 2012, 175(10): 1029-1036. DOI: 10.1093/aje/kwr456
[31]	LUKENDA ZANKO V, DOMISLOVIC V, TRKULJA V, et al. Vitamin D for treatment of non-alcoholic fatty liver disease detected by transient elastography: A randomized, double-blind, placebo-controlled trial[J]. Diabetes Obes Metab, 2020, 22(11): 2097-2106. DOI: 10.1111/dom.14129

Relative Articles

Supplements(0)

Cited By

Proportional views

Proportional views

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Figures(4) / Tables(2)

Get Citation

PDF

XML

Article Metrics

Article views (472) PDF downloads(42)

Relationship between vitamin D level in children and adolescents with nonalcoholic fatty liver disease: A Meta-analysis

DOI: 10.3969/j.issn.1001-5256.2021.03.024

Abstract

References

Proportional views

Catalog

通讯作者: 陈斌, bchen63@163.com

Article Metrics

Proportional views

Related

About Journal

Submission Guideline

Journal Online

Hepatobiliary College

Guidelines

Export File

Citation

Format

Content