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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 37 Issue 3
Mar.  2021
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Article Navigation >  Journal of Clinical Hepatology  > 2021  >  37(3): 616-620

Value of Modified Response Evaluation Criteria in Solid Tumors response in predicting the prognosis of patients with unresectable hepatocellular carcinoma patients after transarterial chemoembolization

DOI: 10.3969/j.issn.1001-5256.2021.03.022
  • 1.

    Air Force Medical University, Xi'an 710032, China

  • 2a.

    Department of Liver Disease and Digestive Interventional Radiology, The First Affiliated Hospital of Air Force Medical University, Xi'an 710032, China

  • 2b.

    Department of Hepatobiliary, Pancreatic and Splenic Surgery, The First Affiliated Hospital of Air Force Medical University, Xi'an 710032, China

  • Received Date: 2020-11-05
  • Accepted Date: 2020-12-24
  • Published Date: 2021-03-20
    Abstract
  •   Objective  To investigate the association of Modified Response Evaluation Criteria in Solid Tumors (mRECIST) response with the prognosis of patients with unresectable hepatocellular carcinoma (HCC) after transarterial embolization (TACE).  Methods  A retrospective analysis was performed for the clinical data of 190 patients with unresectable HCC who were consecutively admitted to Department of Liver Disease and Digestive Interventional Radiology, The First Affiliated Hospital of Air Force Medical University, and treated with TACE from January 2010 to December 2014. The mRECIST criteria were used to evaluate imaging response after TACE; the patients with complete response (CR) or partial response (PR) were enrolled as response group (n=89), and those with progressive disease (PD) or stable disease (SD) were enrolled as non-response group (n=101). The Kaplan-Meier method was used to calculate median survival time, and the log-rank test was used for comparison between groups; the Cox regression model was used to identify the influencing factors for prognosis.  Results  According to the mRECIST criteria, 39 patients (20.5%) achieved CR, 50 (26.3%) achieved PR, 67 (35.3%) had SD, and 34 (17.9%) had PD. The objective response rate based on mRECIST was 46.8% for the whole population. The response group had a significantly longer survival time than the non-response group, and the median survival time was 29.9 (95% confidence interval [CI]: 25.0-34.8) months for the response group and 7.5 (95% CI: 5.7-9.3) months for the non-response group (P < 0.001). The multivariate analysis showed that mRECIST response (hazard ratio [HR]=2.02, P < 0.001), hepatitis B (HR=4.03, P < 0.001), and portal invasion (HR=2.12, P=0.008) were independent risk factors for survival.  Conclusion  The mRECIST response has a certain value in predicting the prognosis of patients with unresectable HCC after TACE.

     

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