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ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 37 Issue 2
Mar.  2021
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Article Navigation >  Journal of Clinical Hepatology  > 2021  >  37(2): 471-474

Role of microRNA-335 in chronic liver diseases

DOI: 10.3969/j.issn.1001-5256.2021.02.047

  • Institute of Parasitic Diseases, Hangzhou Medical College, Hangzhou 310000, China

  • Received Date: 2020-07-28
  • Accepted Date: 2020-08-31
  • Published Date: 2021-02-20
    Abstract
  • In recent years, the regulatory role of microRNAs in liver pathological process has attracted more and more attention. In viral hepatitis and steatohepatitis, microRNA-335 (miRNA-335) regulates the progression of hepatitis via the transcription factor sex-determining region Y-box 4; in the development and progression of progressive liver fibrosis and liver cancer, miRNA-335 affects collagen production, deposition, and degradation in the liver via the target genes including hypoxia-inducible factor 1α, phosphatase and tensin homologue, Rho-associated coiled-coil containing protein kinase 1, plasminogen activator inhibitor-1, twist family bHLH transcription factor 1, and mesenchymal-epithelial transition factor and thus regulates the migration and invasion of hepatic stellate cells and hepatoma cells. This article summarizes the research advances in the role of miRNA-335 in hepatitis, liver fibrosis, and liver cancer in recent years, and based on existing data, it is pointed out that the miRNA-335/QSOX1 regulatory axis may mediate artesunate against schistosomal liver fibrosis by inhibiting hepatic stellate cell activation, so as to provide new ideas for the treatment of liver fibrosis and other liver diseases.

     

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    • References(49)
  • [1]
    THOMAS DL. Global elimination of chronic hepatitis[J]. N Engl J Med, 2019, 380(21): 2041-2050. DOI: 10.1056/NEJMra1810477
    [2]
    SARIN SK, KUMAR M, ESLAM M, et al. Liver diseases in the Asia-Pacific region: A lancet gastroenterology & hepatology commission[J]. Lancet Gastroenterol Hepatol, 2020, 5(2): 167-228. DOI: 10.1016/S2468-1253(19)30342-5
    [3]
    ESTES C, ANSTEE QM, ARIAS-LOSTE MT, et al. Modeling NAFLD disease burden in China, France, Germany, Italy, Japan, Spain, United Kingdom, and United States for the period 2016-2030[J]. J Hepatol, 2018, 69(4): 896-904. DOI: 10.1016/j.jhep.2018.05.036
    [4]
    SEKI E, BRENNER DA. Recent advancement of molecular mechanisms of liver fibrosis[J]. J Hepatobiliary Pancreat Sci, 2015, 22(7): 512-518. DOI: 10.1002/jhbp.245
    [5]
    DOHI O, YASUI K, GEN Y, et al. Epigenetic silencing of miR-335 and its host gene MEST in hepatocellular carcinoma[J]. Int J Oncol, 2013, 42(2): 411-418. DOI: 10.3892/ijo.2012.1724
    [6]
    SHANG J, ZHENG Y, GUO X, et al. Hepatitis B virus replication and sex-determining region Y box 4 production are tightly controlled by a novel positive feedback mechanism[J]. Sci Rep, 2015, 5: 10066. DOI: 10.1038/srep10066
    [7]
    HAN S, TANG Q, LU X, et al. Dysregulation of hepatic microRNA expression profiles with Clonorchis sinensis infection[J]. BMC Infect Dis, 2016, 16(1): 724. DOI: 10.1186/s12879-016-2058-1
    [8]
    CHEN C, WU CQ, ZHANG ZQ, et al. Loss of expression of miR-335 is implicated in hepatic stellate cell migration and activation[J]. Exp Cell Res, 2011, 317(12): 1714-1725. DOI: 10.1016/j.yexcr.2011.05.001
    [9]
    LIU H, LI W, CHEN C, et al. MiR-335 acts as a potential tumor suppressor miRNA via downregulating ROCK1 expression in hepatocellular carcinoma[J]. Tumour Biol, 2015, 36(8): 6313-6319. DOI: 10.1007/s13277-015-3317-2
    [10]
    YIN C. Molecular mechanisms of Sox transcription factors during the development of liver, bile duct, and pancreas[J]. Semin Cell Dev Biol, 2017, 63: 68-78. DOI: 10.1016/j.semcdb.2016.08.015
    [11]
    JIAO Y, ZHAO J, ZHANG Z, et al. SRY-Box containing gene 4 promotes liver steatosis by upregulation of SREBP-1c[J]. Diabetes, 2018, 67(11): 2227-2238. DOI: 10.2337/db18-0184
    [12]
    NAKANISHI N, NAKAGAWA Y, TOKUSHIGE N, et al. The up-regulation of microRNA-335 is associated with lipid metabolism in liver and white adipose tissue of genetically obese mice[J]. Biochem Biophys Res Commun, 2009, 385(4): 492-496. DOI: 10.1016/j.bbrc.2009.05.058
    [13]
    OISHI Y, SPANN NJ, LINK VM, et al. SREBP1 contributes to resolution of pro-inflammatory TLR4 signaling by reprogramming fatty acid metabolism[J]. Cell Metab, 2017, 25(2): 412-427. DOI: 10.1016/j.cmet.2016.11.009
    [14]
    WANG X, MAO W, FANG C, et al. Dusp14 protects against hepatic ischaemia-reperfusion injury via Tak1 suppression[J]. J Hepatol, 2018, 68(1): 118-129. DOI: 10.1016/j.jhep.2017.08.032
    [15]
    HU J, ZHU XH, ZHANG XJ, et al. Targeting TRAF3 signaling protects against hepatic ischemia/reperfusions injury[J]. J Hepatol, 2016, 64(1): 146-159. DOI: 10.1016/j.jhep.2015.08.021
    [16]
    WANG PX, ZHANG XJ, LUO P, et al. Hepatocyte TRAF3 promotes liver steatosis and systemic insulin resistance through targeting TAK1-dependent signalling[J]. Nat Commun, 2016, 7: 10592. DOI: 10.1038/ncomms10592
    [17]
    BAO CX, ZHANG DX, WANG NN, et al. MicroRNA-335-5p suppresses lower extremity deep venous thrombosis by targeted inhibition of PAI-1 via the TLR4 signalingpathway[J]. J Cell Biochem, 2018, 119(6): 4692-4710. DOI: 10.1002/jcb.26647
    [18]
    LIU FJ, KAUR P, KAROLINA DS, et al. MiR-335 regulates Hif-1α to reduce cell death in both mouse cell line and rat ischemic models[J]. PLoS One, 2015, 10(6): e0128432. DOI: 10.1371/journal.pone.0128432
    [19]
    KABIR TD, LEIGH RJ, TASENA H, et al. A miR-335/COX-2/PTEN axis regulates the secretory phenotype of senescent cancer-associated fibroblasts[J]. Aging (Albany NY), 2016, 8(8): 1608-1635. DOI: 10.18632/aging.100987
    [20]
    HU Y, HU D, YU H, et al. Hypoxia-inducible factor 1α and ROCK1 regulate proliferation and collagen synthesis in hepatic stellate cells under hypoxia[J]. Mol Med Rep, 2018, 18(4): 3997-4003. http://www.ncbi.nlm.nih.gov/pubmed/30132575
    [21]
    ZHANG F, HAO M, JIN H, et al. Canonical hedgehog signalling regulates hepatic stellate cell-mediated angiogenesis in liver fibrosis[J]. Br J Pharmacol, 2017, 174(5): 409-423. DOI: 10.1111/bph.13701
    [22]
    HAN J, HE Y, ZHAO H, et al. Hypoxia inducible factor-1 promotes liver fibrosis in nonalcoholic fatty liver disease by activating PTEN/p65 signaling pathway[J]. J Cell Biochem, 2019, 120(9): 14735-14744. DOI: 10.1002/jcb.28734
    [23]
    WEI S, ZHOU H, WANG Q, et al. RIP3 deficiency alleviates liver fibrosis by inhibiting ROCK1-TLR4-NF-κB pathway in macrophages[J]. FASEB J, 2019, 33(10): 11180-11193. DOI: 10.1096/fj.201900752R
    [24]
    SHI CY, FAN Y, LIU B, et al. HIF1 contributes to hypoxia-induced pancreatic cancer cells invasion via promoting QSOX1 expression[J]. Cell Physiol Biochem, 2013, 32(3): 561-568. DOI: 10.1159/000354460
    [25]
    KATCHMAN BA, ANTWI K, HOSTETTER G, et al. Quiescin sulfhydryl oxidase 1 promotes invasion of pancreatic tumor cells mediated by matrix metalloproteinases[J]. Mol Cancer Res, 2011, 9(12): 1621-1631. DOI: 10.1158/1541-7786.MCR-11-0018
    [26]
    YANG JW, HIEN TT, LIM SC, et al. Pin1 induction in the fibrotic liver and its roles in TGF-β1 expression and Smad2/3 phosphorylation[J]. J Hepatol, 2014, 60(6): 1235-1241. DOI: 10.1016/j.jhep.2014.02.004
    [27]
    FLEVARIS P, VAUGHAN D. The role of plasminogen activator inhibitor type-1 in fibrosis[J]. Semin Thromb Hemost, 2017, 43(2): 169-177. http://d.wanfangdata.com.cn/periodical/82f79194318957c4b32216c05179ee37
    [28]
    WANG J, WANG X, LIU F, et al. microRNA-335 inhibits colorectal cancer HCT116 cells growth and epithelial-mesenchymal transition (EMT) process by targeting Twist1[J]. Pharmazie, 2017, 72(8): 475-481. http://www.ncbi.nlm.nih.gov/pubmed/29441907
    [29]
    YEO SY, LEE KW, SHIN D, et al. A positive feedback loop bi-stably activates fibroblasts[J]. Nat Commun, 2018, 9(1): 3016. DOI: 10.1038/s41467-018-05274-6
    [30]
    LI Z, CHEN B, DONG W, et al. MKL1 promotes endothelial-to-mesenchymal transition and liver fibrosis by activating TWIST1 transcription[J]. Cell Death Dis, 2019, 10(12): 899. DOI: 10.1038/s41419-019-2101-4
    [31]
    REN J, ZHANG J, RUDEMILLER NP, et al. Twist1 in infiltrating macrophages attenuates kidney fibrosis via matrix metallopeptidase 13-mediated matrix degradation[J]. J Am Soc Nephrol, 2019, 30(9): 1674-1685. DOI: 10.1681/ASN.2018121253
    [32]
    CHEN S, XIA X. Long noncoding RNA NEAT1 suppresses sorafenib sensitivity of hepatocellular carcinoma cells via regulating miR-335-c-Met[J]. J Cell Physiol, 2019.[Epub ahead of print]
    [33]
    BOUATTOUR M, RAYMOND E, QIN S, et al. Recent developments of c-Met as a therapeutic target in hepatocellular carcinoma[J]. Hepatology, 2018, 67(3): 1132-1149. DOI: 10.1002/hep.29496
    [34]
    HU J, CHE L, LI L, et al. Co-activation of AKT and c-Met triggers rapid hepatocellular carcinoma development via the mTORC1/FASN pathway in mice[J]. Sci Rep, 2016, 6: 20484. DOI: 10.1038/srep20484
    [35]
    YOU H, DING W, DANG H, et al. c-Met represents a potential therapeutic target for personalized treatment in hepatocellular carcinoma[J]. Hepatology, 2011, 54(3): 879-889. DOI: 10.1002/hep.24450
    [36]
    YOO BK, GREDLER R, CHEN D, et al. c-Met activation through a novel pathway involving osteopontin mediates oncogenesis by the transcription factor LSF[J]. J Hepatol, 2011, 55(6): 1317-1324. DOI: 10.1016/j.jhep.2011.02.036
    [37]
    LI L, PILO GM, LI X, et al. Inactivation of fatty acid synthase impairs hepatocarcinogenesis driven by AKT in mice and humans[J]. J Hepatol, 2016, 64(2): 333-341. DOI: 10.1016/j.jhep.2015.10.004
    [38]
    WANG RK, SHAO XM, YANG JP, et al. MicroRNA-145 inhibits proliferation and promotes apoptosis of HepG2 cells by targeting ROCK1 through the ROCK1/NF-κB signaling pathway[J]. Eur Rev Med Pharmacol Sci, 2019, 23(7): 2777-2785. http://www.ncbi.nlm.nih.gov/pubmed/31002128
    [39]
    WANG Y, ZENG XD, WANG NN, et al. Long noncoding RNA DANCR, working as a competitive endogenous RNA, promotes ROCK1-mediated proliferation and metastasis via decoying of miR-335-5p and miR-1972 in osteosarcoma[J]. Mol Cancer, 2018, 17(1): 89. DOI: 10.1186/s12943-018-0837-6
    [40]
    LIANG H, ZHANG C, GUAN H, et al. LncRNA DANCR promotes cervical cancer progression by upregulating ROCK1 via sponging miR-335-5p[J]. J Cell Physiol, 2019, 234(5): 7266-7278. DOI: 10.1002/jcp.27484
    [41]
    GUO D, LI Y, CHEN Y, et al. DANCR promotes HCC progression and regulates EMT by sponging miR-27a-3p via ROCK1/LIMK1/COFILIN1 pathway[J]. Cell Prolif, 2019, 52(4): e12628.
    [42]
    MENG J, CHEN S, HAN JX, et al. Twist1 regulates vimentin through Cul2 circular RNA to promote EMT in hepatocellular carcinoma[J]. Cancer Res, 2018, 78(15): 4150-4162. DOI: 10.1158/0008-5472.CAN-17-3009
    [43]
    XIAO T, ZHANG Q, ZONG S, et al. Protease-activated receptor-1 (PAR1) promotes epithelial-endothelial transition through Twist1 in hepatocellular carcinoma[J]. J Exp Clin Cancer Res, 2018, 37(1): 185. DOI: 10.1186/s13046-018-0858-4
    [44]
    YIN J, WANG L, ZHU JM, et al. Prp19 facilitates invasion of hepatocellular carcinoma via p38 mitogen-activated protein kinase/twist1 pathway[J]. Oncotarget, 2016, 7(16): 21939-21951. DOI: 10.18632/oncotarget.7877
    [45]
    YALIM-CAMCI I, BALCIK-ERCIN P, CETIN M, et al. ETS1 is coexpressed with ZEB2 and mediates ZEB2-induced epithelial-mesenchymal transition in human tumors[J]. Mol Carcinog, 2019, 58(6): 1068-1081. DOI: 10.1002/mc.22994
    [46]
    KAN QE, SU Y, YANG HH. MicroRNA-335 is downregulated in papillary thyroid cancer and suppresses cancer cell growth, migration and invasion by directly targeting ZEB2[J]. Oncol Lett, 2017, 14(6): 7622-7628. http://www.researchgate.net/publication/320190432_MicroRNA-335_is_downregulated_in_papillary_thyroid_cancer_and_suppresses_cancer_cell_growth_migration_and_invasion_by_directly_targeting_ZEB2
    [47]
    WANG F, LI L, PIONTEK K, et al. Exosome miR-335 as a novel therapeutic strategy in hepatocellular carcinoma[J]. Hepatology, 2018, 67(3): 940-954. DOI: 10.1002/hep.29586
    [48]
    DU WW, TANG HC, LEI Z, et al. miR-335-5p inhibits TGF-beta1-induced epithelial-mesenchymal transition in non-small cell lung cancer via ROCK1[J]. Respir Res, 2019, 20(1): 225. DOI: 10.1186/s12931-019-1184-x
    [49]
    SUN ZF, ZHANG Z, LIU ZD, et al. MicroRNA-335 inhibits invasion and metastasis of colorectal cancer by targeting ZEB2[J]. Med Oncol, 2014, 31(6): 982. DOI: 10.1007/s12032-014-0982-8
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