中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 37 Issue 2
Mar.  2021
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Article Contents

Liver transplantation for liver cancer in the era of immunotherapy

DOI: 10.3969/j.issn.1001-5256.2021.02.001
  • Received Date: 2020-10-09
  • Accepted Date: 2020-10-09
  • Published Date: 2021-02-20
  • Most patients with liver cancer in China cannot get radical surgical treatment at the time of diagnosis, and the breakthrough of immunotherapy for liver cancer in recent years has brought new hope to the patients with advanced liver cancer. In the field of liver transplantation for liver cancer, immunotherapy has attracted much attention because of its dual role in tumor immunity and transplantation immunity. There are also innovative applications of immunotherapy in preoperative down-staging treatment and the treatment of tumor recurrence after transplantation. In the era of immunotherapy, how to apply the thinking of transplant oncology to benefit liver cancer patients undergoing liver transplantation is a brand-new topic, and this requires multidisciplinary collaboration in clinical practice to explore the best treatment strategies for liver cancer patients undergoing liver transplantation and finally improve the prognosis of patients with advanced liver cancer.

     

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  • [1]
    FINN RS, QIN S, IKEDA M, et al. Atezolizumab plus Bevacizumab in unresectable hepatocellular carcinoma[J]. N Engl J Med, 2020, 382(20): 1894-1905. DOI: 10.1056/NEJMoa1915745
    [2]
    HATO T, GOYAL L, GRETEN TF, et al. Immune checkpoint blockade in hepatocellular carcinoma: Current progress and future directions[J]. Hepatology, 2014, 60(5): 1776-1782. DOI: 10.1002/hep.27246
    [3]
    DISIS ML. Mechanism of action of immunotherapy[J]. Semin Oncol, 2014, 41(Suppl 5): s3-s13.
    [4]
    DATTA M, COUSSENS LM, NISHIKAWA H, et al. Reprogramming the tumor microenvironment to improve immunotherapy: Emerging strategies and combination therapies[J]. Am Soc Clin Oncol Educ Book, 2019, 39: 165-174.
    [5]
    EL-KHOUEIRY AB, SANGRO B, YAU T, et al. Nivolumab in patients with advanced hepatocellular carcinoma (CheckMate 040): An open-label, non-comparative, phase 1/2 dose escalation and expansion trial[J]. Lancet, 2017, 389(10088): 2492-2502. DOI: 10.1016/S0140-6736(17)31046-2
    [6]
    QIN S, REN Z, MENG Z, et al. Camrelizumab in patients with previously treated advanced hepatocellular carcinoma: A multicentre, open-label, parallel-group, randomised, phase 2 trial[J]. Lancet Oncol, 2020, 21(4): 571-580. DOI: 10.1016/S1470-2045(20)30011-5
    [7]
    KUDO M. Immune checkpoint inhibition in hepatocellular carcinoma: Basics and ongoing clinical trials[J]. Oncology, 2017, 92(Suppl 1): 50-62.
    [8]
    IKEDA M, SUNG MW, KUDO M, et al. A phase 1b trial of lenvatinib (LEN) plus pembrolizumab (PEM) in patients (pts) with unresectable hepatocellular carcinoma (uHCC)[J]. J Clin Oncol, 2018, 36(15 Suppl): 4076.
    [9]
    KASEB AO, VENCE L, BLANDO J, et al. Immunologic correlates of pathologic complete response to preoperative immunotherapy in hepatocellular carcinoma[J]. Cancer Immunol Res, 2019, 7(9): 1390-1395. DOI: 10.1158/2326-6066.CIR-18-0605
    [10]
    CHEN X, ZHANG Y, ZHANG N, et al. Lenvatinib combined nivolumab injection followed by extended right hepatectomy is a feasible treatment for patients with massive hepatocellular carcinoma: A case report[J]. Onco Targets Ther, 2019, 12: 7355-7359. DOI: 10.2147/OTT.S217123
    [11]
    WEHRENBERG-KLEE E, GOYAL L, DUGAN M, et al. Y-90 radioembolization combined with a PD-1 inhibitor for advanced hepatocellular carcinoma[J]. Cardiovasc Intervent Radiol, 2018, 41(11): 1799-1802. DOI: 10.1007/s00270-018-1993-1
    [12]
    SCHWACHA-EIPPER B, MINCIUNA I, BANZ V, et al. Immunotherapy as a downstaging therapy for liver transplantation[J]. Hepatology, 2020. [Epub ahead of print]
    [13]
    SABERIANFAR S, NGUYEN LS, MANOUCHEHRI A, et al. Solid organ transplant rejection associated with immune-checkpoint inhibitors[J]. Ann Oncol, 2020, 31(4): 543-544. DOI: 10.1016/j.annonc.2020.01.012
    [14]
    HO CM, CHEN HL, HU RH, et al. Harnessing immunotherapy for liver recipients with hepatocellular carcinoma: A review from a transplant oncology perspective[J]. Ther Adv Med Oncol, 2019, 11: 1758835919843463.
    [15]
    de TONI EN, GERBES AL. Tapering of immunosuppression and sustained treatment with nivolumab in a liver transplant recipient[J]. Gastroenterology, 2017, 152(6): 1631-1633. DOI: 10.1053/j.gastro.2017.01.063
    [16]
    RAMMOHAN A, REDDY MS, FAROUK M, et al. Pembrolizumab for metastatic hepatocellular carcinoma following live donor liver transplantation: The silver bullet?[J]. Hepatology, 2018, 67(3): 1166-1168. DOI: 10.1002/hep.29575
    [17]
    MUNKER S, de TONI EN. Use of checkpoint inhibitors in liver transplant recipients[J]. United European Gastroenterol J, 2018, 6(7): 970-973. DOI: 10.1177/2050640618774631
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