中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 36 Issue 12
Dec.  2020
Turn off MathJax
Article Contents

Research advances in the role of myeloid-derived suppressor cells in liver diseases

DOI: 10.3969/j.issn.1001-5256.2020.12.045
Research funding:

 

  • Received Date: 2020-05-21
  • Published Date: 2020-12-20
  • In recent years,more and more studies have shown that myeloid-derived suppressor cells( MDSCs) participate in the development and progression of various chronic liver diseases including chronic viral hepatitis,alcoholic liver disease,nonalcoholic fatty liver disease,autoimmune liver diseases,and liver cancer. As a type of cells derived from bone marrow progenitor cells and immature myeloid cells,MDSCs play an important role in the development,progression,and repair of liver diseases by regulating inflammatory response and the differentiation and function of immune cells. This article reviews the research advances in the association between MDSCs and various liver diseases,in order to provide new thoughts for the clinical diagnosis,prognosis,and treatment of chronic liver diseases.

     

  • loading
  • [1] PAIK JM,GOLABI P,YOUNOSSI Y,et al. Changes in the global burden of chronic liver diseases from 2012 to 2017:The growing impact of nonalcoholic fatty liver disease[J]. Hepatology,2020.[Online ahead of print]
    [2] SARIN SK,KUMAR M,ESLAM M,et al. Liver diseases in the Asia-Pacific region:A Lancet Gastroenterology&Hepatology Commission[J]. Lancet Gastroenterol Hepatol,2020,5(2):167-228.
    [3] GABRILOVICH DI,BRONTE V,CHEN SH,et al. The terminology issue for myeloid-derived suppressor cells[J]. Cancer Res,2007,67(1):425; author reply 426.
    [4] MI Y,GUO N,LUAN J,et al. The emerging role of myeloidderived suppressor cells in the glioma immune suppressive microenvironment[J]. Front Immunol,2020,11:737.
    [5] NAKAMURA T,USHIGOME H. Myeloid-derived suppressor cells as a regulator of immunity in organ transplantation[J]. Int J Mol Sci,2018,19(8):2357.
    [6] GAO Y,SUN W,SHANG W,et al. Lnc-C/EBPβnegatively regulates the suppressive function of myeloid-derived suppressor cells[J]. Cancer Immunol Res,2018,6(11):1352-1363.
    [7] ELLIOTT DM,SINGH N,NAGARKATTI M,et al. Cannabidiol attenuates experimental autoimmune encephalomyelitis model of multiple sclerosis through induction of myeloid-derived suppressor cells[J]. Front Immunol,2018,9:1782.
    [8] TANG CH,CHANG S,HASHIMOTO A,et al. Secretory IgM exacerbates tumor progression by inducing accumulations of MDSCs in mice[J]. Cancer Immunol Res,2018,6(6):696-710.
    [9] LIU YF,ZHUANG KH,CHEN B,et al. Expansion and activation of monocytic-myeloid-derived suppressor cell via STAT3/arginase-I signaling in patients with ankylosing spondylitis[J]. Arthritis Res Ther,2018,20(1):168.
    [10] CROAGH CM,LUBEL JS. Natural history of chronic hepatitis B:Phases in a complex relationship[J]. World J Gastroenterol,2014,20(30):10395-10404.
    [11] FANG Z,LI J,YU X,et al. Polarization of monocytic myeloid-derived suppressor cells by hepatitis B surface antigen is mediated via ERK/IL-6/STAT3 signaling feedback and restrains the activation of T cells in chronic hepatitis B virus infection[J]. J Immunol,2015,195(10):4873-4883.
    [12] PAL S,NANDI M,DEY D,et al. Myeloid-derived suppressor cells induce regulatory T cells in chronically HBV infected patients with high levels of hepatitis B surface antigen and persist after antiviral therapy[J]. Aliment Pharmacol Ther,2019,49(10):1346-1359.
    [13] LV Y,CUI M,LV Z,et al. Expression and significance of peripheral myeloid-derived suppressor cells in chronic hepatitis B patients[J]. Clin Res Hepatol Gastroenterol,2018,42(5):462-469.
    [14] HUANG A,ZHANG B,YAN W,et al. Myeloid-derived suppressor cells regulate immune response in patients with chronic hepatitis B virus infection through PD-1-induced IL-10[J]. J Immunol,2014,193(11):5461-5469.
    [15] KONG X,SUN R,CHEN Y,et al.γδT cells drive myeloidderived suppressor cell-mediated CD8+T cell exhaustion in hepatitis B virus-induced immunotolerance[J]. J Immunol,2014,193(4):1645-1653.
    [16] YANG F,YU X,ZHOU C,et al. Hepatitis B e antigen induces the expansion of monocytic myeloid-derived suppressor cells to dampen T-cell function in chronic hepatitis B virus infection[J]. PLo S Pathog,2019,15(4):e1007690.
    [17] WEBER C. Hepatitis:Myeloid-derived suppressor cells in HBV infection[J]. Nat Rev Gastroenterol Hepatol,2015,12(7):370.
    [18] PALLETT LJ,GILL US,QUAGLIA A,et al. Metabolic regulation of hepatitis B immunopathology by myeloid-derived suppressor cells[J]. Nat Med,2015,21(6):591-600.
    [19] ZENG Y,LI Y,XU Z,et al. Myeloid-derived suppressor cells expansion is closely associated with disease severity and progression in HBV-related acute-on-chronic liver failure[J].J Med Virol,2019,91(8):1510-1518.
    [20] ZHENG Z,SZE CW,KENG CT,et al. Hepatitis C virus mediated chronic inflammation and tumorigenesis in the humanised immune system and liver mouse model[J]. PLo S One,2017,12(9):e0184127.
    [21] TACKE RS,LEE HC,GOH C,et al. Myeloid suppressor cells induced by hepatitis C virus suppress T-cell responses through the production of reactive oxygen species[J]. Hepatology,2012,55(2):343-353.
    [22] WANG L,CAO D,WANG L,et al. HCV-associated exosomes promote myeloid-derived suppressor cell expansion via inhibiting miR-124 to regulate T follicular cell differentiation and function[J]. Cell Discov,2018,4:51.
    [23] WANG M,PING Y,LI Z,et al. Polarization of granulocytic myeloid-derived suppressor cells by hepatitis C core protein is mediated via IL-10/STAT3 signalling[J]. J Viral Hepat,2019,26(2):246-257.
    [24] GOH CC,ROGGERSON KM,LEE HC,et al. Hepatitis C virus-induced myeloid-derived suppressor cells suppress NK cell IFN-γproduction by altering cellular metabolism via arginase-1[J]. J Immunol,2016,196(5):2283-2292.
    [25] TELATIN V,NICOLI F,FRASSON C,et al. In chronic hepatitis C infection,myeloid-derived suppressor cell accumulation and T cell dysfunctions revert partially and late after successful direct-acting antiviral treatment[J]. Front Cell Infect Microbiol,2019,9:190.
    [26] WANG H,MA L,YIN Q,et al. Prevalence of alcoholic liver disease and its association with socioeconomic status in north-eastern China[J]. Alcohol Clin Exp Res,2014,38(4):1035-1041.
    [27] GAO B,AHMAD MF,NAGY LE,et al. Inflammatory pathways in alcoholic steatohepatitis[J]. J Hepatol,2019,70(2):249-259.
    [28] LI S,WANG N,TAN HY,et al. Expansion of granulocytic,myeloid-derived suppressor cells in response to ethanol-induced acute liver damage[J]. Front Immunol,2018,9:1524.
    [29] GAO M,HUANG A,SUN Z,et al. Granulocytic myeloid-derived suppressor cell population increases with the severity of alcoholic liver disease[J]. J Cell Mol Med,2019,23(3):2032-2041.
    [30] TSUNASHIMA H,TSUNEYAMA K,MORITOKI Y,et al. Accumulated myeloid-derived suppressor cells demonstrate distinct phenotypes and functions in two non-alcoholic steatohepatitis mouse models[J]. Hepatobiliary Surg Nutr,2015,4(5):313-319.
    [31] YAO L,ABE M,KAWASAKI K,et al. Characterization of liver monocytic myeloid-derived suppressor cells and their role in a murine model of non-alcoholic fatty liver disease[J]. PLo S One,2016,11(2):e0149948.
    [32] SRIVASTAVA N,IYER S,SUDAN R,et al. A small-molecule inhibitor of SHIP1 reverses age-and diet-associated obesity and metabolic syndrome[J]. JCI Insight,2016,1(11).
    [33] OHL K,TENBROCK K. Reactive oxygen species as regulators of MDSC-mediated immune suppression[J]. Front Immunol,2018,9:2499.
    [34] LIBERAL R,MIELI-VERGANI G,VERGANI D. Autoimmune hepatitis:From mechanisms to therapy[J]. Rev Clin Esp,2016,216(7):372-383.
    [35] HSIEH CC,HUNG CH,LU L,et al. Hepatic immune tolerance induced by hepatic stellate cells[J]. World J Gastroenterol,2015,21(42):11887-11892.
    [36] LI H,DAI F,PENG Q,et al. Myeloid-derived suppressor cells suppress CD4+and CD8+T cell responses in autoimmune hepatitis[J]. Mol Med Rep,2015,12(3):3667-3673.
    [37] CHEN X,ZHANG Z,BI Y,et al. m TOR signaling disruption from myeloid-derived suppressive cells protects against immune-mediated hepatic injury through the HIF1α-dependent glycolytic pathway[J]. J Leukoc Biol,2016,100(6):1349-1362.
    [38] HAMMERICH L,WARZECHA KT,STEFKOVA M,et al. Cyclic adenosine monophosphate-responsive element modulator alpha overexpression impairs function of hepatic myeloid-derived suppressor cells and aggravates immune-mediated hepatitis in mice[J]. Hepatology,2015,61(3):990-1002.
    [39] LIAN M,ZHANG J,ZHAO L,et al. Interleukin-35 regulates immune microenvironment of autoimmune hepatitis through inducing the expansion of myeloid-derived suppressor cells[J]. Front Immunol,2019,10:2577.
    [40] BRAY F,FERLAY J,SOERJOMATARAM I,et al. Global cancer statistics 2018:GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J]. CA Cancer J Clin,2018,68(6):394-424.
    [41] ZHANG H,HE G,KONG Y,et al. Tumour-activated liver stromal cells regulate myeloid-derived suppressor cells accumulation in the liver[J]. Clin Exp Immunol,2017,188(1):96-108.
    [42] ELWAN N,SALEM ML,KOBTAN A,et al. High numbers of myeloid derived suppressor cells in peripheral blood and ascitic fluid of cirrhotic and HCC patients[J]. Immunol Invest,2018,47(2):169-180.
    [43] NAN J,XING YF,HU B,et al. Endoplasmic reticulum stress induced LOX-1+CD15+polymorphonuclear myeloid-derived suppressor cells in hepatocellular carcinoma[J]. Immunology,2018,154(1):144-155.
    [44] YU SJ,MA C,HEINRICH B,et al. Targeting the crosstalk between cytokine-induced killer cells and myeloid-derived suppressor cells in hepatocellular carcinoma[J]. J Hepatol,2019,70(3):449-457.
    [45] LACOTTE S,SLITS F,ORCI LA,et al. Impact of myeloidderived suppressor cell on Kupffer cells from mouse livers with hepatocellular carcinoma[J]. Oncoimmunology, 2016, 5(11):e1234565.
    [46] DENG Y,CHENG J,FU B,et al. Hepatic carcinoma-associated fibroblasts enhance immune suppression by facilitating the generation of myeloid-derived suppressor cells[J]. Oncogene,2017,36(8):1090-1101.
    [47] XU Y,FANG F,JIAO H,et al. Activated hepatic stellate cells regulate MDSC migration through the SDF-1/CXCR4 axis in an orthotopic mouse model of hepatocellular carcinoma[J].Cancer Immunol Immunother,2019,68(12):1959-1969.
    [48] LU LC,CHANG CJ,HSU CH. Targeting myeloid-derived suppressor cells in the treatment of hepatocellular carcinoma:Current state and future perspectives[J]. J Hepatocell Carcinoma,2019,6:71-84.
    [49] HSIEH CC,HUNG CH,CHIANG M,et al. Hepatic stellate cells enhance liver cancer progression by inducing myeloidderived suppressor cells through interleukin-6 signaling[J].Int J Mol Sci,2019,20(20):5079.
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Article Metrics

    Article views (465) PDF downloads(53) Cited by()
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return