中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 36 Issue 12
Dec.  2020
Turn off MathJax
Article Contents

Role of zinc finger proteins in the development and progression of hepatocellular carcinoma

DOI: 10.3969/j.issn.1001-5256.2020.12.042
Research funding:

 

  • Received Date: 2020-05-28
  • Published Date: 2020-12-20
  • There are complex mechanisms in the development and progression of hepatocellular carcinoma,which have not been fully clarified at present. Zinc finger protein family is the largest transcription factor family in human genome,and more and more evidence has shown that zinc finger proteins play an important role in the development and progression of hepatocellular carcinoma and are expected to become new tumor biomarkers and therapeutic targets for hepatocellular carcinoma. This article reviews the structure and biological functions of zinc finger proteins and their role and regulatory mechanisms in hepatocellular carcinoma.

     

  • loading
  • [1] ZHENG R,QU C,ZHANG S,et al. Liver cancer incidence and mortality in China:Temporal trends and projections to2030[J]. Chin J Cancer Res,2018,30(6):571-579.
    [2] CHEN WY,REN N. Advances in molecular targeted therapy for hepatocellular carcinoma[J]. J Clin Hepatol,2018,34(7):1387-1394.(in Chinese)陈万勇,任宁.肝细胞癌分子靶向治疗进展[J].临床肝胆病杂志,2018,34(7):1387-1394.
    [3] LANDER ES,LINTON LM,BIRREN B,et al. Initial sequencing and analysis of the human genome[J]. Nature,2001,409(6822):860-921.
    [4] KRISHNA SS,MAJUMDAR I,GRISHIN NV. Structural classification of zinc fingers:Survey and summary[J]. Nucleic Acids Res,2003,31(2):532-550.
    [5] XIE W,QIAO X,SHANG L,et al. Knockdown of ZNF233 suppresses hepatocellular carcinoma cell proliferation and tumorigenesis[J]. Gene,2018,679:179-185.
    [6] PIERACCIOLI M,NICOLAI S,ANTONOV A,et al. ZNF281contributes to the DNA damage response by controlling the expression of XRCC2 and XRCC4[J]. Oncogene,2016,35(20):2592-2601.
    [7] FIDALGO M,HUANG X,GUALLAR D,et al. Zfp281 coordinates opposing functions of Tet1 and Tet2 in pluripotent states[J]. Cell Stem Cell,2016,19(3):355-369.
    [8] CHEN HJ,ZHANG QH,ZHANG W. Effect of ZNF281 on proliferation of hepatocellular carcinoma cells[J]. Chin J Pathophysiol,2018,34(5):812-818.(in Chinese)陈华剑,张钦红,张薇.锌指蛋白281对肝癌细胞增殖的影响[J].中国病理生理杂志,2018,34(5):812-818.
    [9] ALEXANDER TB,GU Z,IACOBUCCI I,et al. The genetic basis and cell of origin of mixed phenotype acute leukaemia[J].Nature,2018,562(7727):373-379.
    [10] ZALIOVA M,STUCHLY J,WINKOWSKA L,et al. Genomic landscape of pediatric B-other acute lymphoblastic leukemia in a consecutive European cohort[J]. Haematologica,2019,104(7):1396-1406.
    [11] HE L,FAN X,LI Y,et al. Overexpression of zinc finger protein 384(ZNF 384),a poor prognostic predictor,promotes cell growth by upregulating the expression of Cyclin D1 in Hepatocellular carcinoma[J]. Cell Death Dis,2019,10(6):444.
    [12] LI K,GAO B,LI J,et al. ZNF32 protects against oxidative stress-induced apoptosis by modulating C1QBP transcription[J]. Oncotarget,2015,6(35):38107-38126.
    [13] SILVA FP,HAMAMOTO R,FURUKAWA Y,et al. TIPUH1 encodes a novel KRAB zinc-finger protein highly expressed in human hepatocellular carcinomas[J]. Oncogene,2006,25(36):5063-5070.
    [14] SHIGEMATSU S,FUKUDA S,NAKAYAMA H,et al. ZNF689suppresses apoptosis of hepatocellular carcinoma cells through the down-regulation of Bcl-2 family members[J].Exp Cell Res,2011,317(13):1851-1859.
    [15] DIVISATO G,FORMICOLA D,ESPOSITO T,et al. ZNF687mutations in severe paget disease of bone associated with giant cell tumor[J]. Am J Hum Genet,2016,98(2):275-286.
    [16] ZHANG T,HUANG Y,LIU W,et al. Overexpression of zinc finger protein 687 enhances tumorigenic capability and promotes recurrence of hepatocellular carcinoma[J]. Oncogenesis,2017,6(7):e363.
    [17] CHENG K,CHEN Z,LIU L,et al. ZNF667 serves as a putative oncogene in human hepatocellular carcinoma[J]. Cell Physiol Biochem,2017,41(6):2523-2533.
    [18] SCHNABL B,VALLETTA D,KIROVSKI G,et al. Zinc finger protein 267 is up-regulated in hepatocellular carcinoma and promotes tumor cell proliferation and migration[J]. Exp Mol Pathol,2011,91(3):695-701.
    [19] SI W,ZHAO Y,ZHOU J,et al. The coordination between ZNF217 and LSD1 contributes to hepatocellular carcinoma progress and is negatively regulated by miR-101[J]. Exp Cell Res,2019,379(1):1-10.
    [20] LIANG Y,LI Q,CHEN K,et al. Zinc finger protein 307 functions as a tumor-suppressor and inhibits cell proliferation by inducing apoptosis in hepatocellular carcinoma[J]. Oncol Rep,2017,38(4):2229-2236.
    [21] TO AK,CHEN GG,CHAN UP,et al. ZBP-89 enhances Bak expression and causes apoptosis in hepatocellular carcinoma cells[J]. Biochim Biophys Acta,2011,1813(1):222-230.
    [22] GUAN C,HE L,CHANG Z,et al. ZNF774 is a potent suppressor of hepatocarcinogenesis through dampening the NOTCH2 signaling[J]. Oncogene,2020,39(8):1665-1680.
    [23] CHEN S,XIAO Z,ZHOU J,et al. ZNF382:A transcription inhibitor down-regulated in multiple tumors due to promoter methylation[J]. Clin Chim Acta,2020,500:220-225.
    [24] DANG S,ZHOU J,CHEN Y,et al. Dynamic expression of ZNF382 and its tumor-suppressor role in hepatitis B virusrelated hepatocellular carcinogenesis[J]. Oncogene,2019,38(24):4804-4819.
    [25] FAN Y,ZHAN Q,XU H,et al. Epigenetic identification of ZNF545 as a functional tumor suppressor in multiple myeloma via activation of p53 signaling pathway[J]. Biochem Biophys Res Commun,2016,474(4):660-666.
    [26] FAN Y,WANG Y,FU S,et al. Methylation-regulated ZNF545inhibits growth of the p53-mutant KYSE150 cell line by inducing p21 and Bax[J]. Exp Ther Med,2019,18(3):1563-1570.
    [27] YANG W,YANG S,ZHANG M,et al. ZNF545 suppresses human hepatocellular carcinoma growth by inhibiting NF-k B signaling[J]. Genes Cancer,2017,8(3-4):528-535.
    [28] GALAN-CARIDAD JM,HAREL S,ARENZANA TL,et al. Zfx controls the self-renewal of embryonic and hematopoietic stem cells[J]. Cell,2007,129(2):345-357.
    [29] LAI KP,CHEN J,HE M,et al. Overexpression of ZFX confers self-renewal and chemoresistance properties in hepatocellular carcinoma[J]. Int J Cancer,2014,135(8):1790-1799.
    [30] PAOLONI-GIACOBINO A,KERN I,RUMPLER Y,et al. Familial t(6; 21)(p21. 1; p13)translocation associated with male-only sterility[J]. Clin Genet,2000,58(4):324-328.
    [31] DONG XY,YANG XA,WANG YD,et al. Zinc-finger protein ZNF165 is a novel cancer-testis antigen capable of eliciting antibody response in hepatocellular carcinoma patients[J]. Br J Cancer,2004,91(8):1566-1570.
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Article Metrics

    Article views (563) PDF downloads(64) Cited by()
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return