Value of early fluid resuscitation endpoints in evaluating blood volume in patients with acute pancreatitis

Objective To investigate the value of early fluid resuscitation endpoints in evaluating blood volume in patients with acute pancreatitis. Methods A retrospective analysis was performed for the clinical data of 445 previously untreated patients with acute pancreatitis who were admitted to The First Affiliated Hospital of Guangxi Medical University from 2003 to 2016 and had an onset time of less than 24 hours,and according the fluid resuscitation endpoints of mean arterial pressure( MAP),hematocrit( HCT),and blood urea nitrogen( BUN),the patients were divided into standard-reaching group( MAP > 65 mm Hg,BUN < 7. 14 mmol/L,and HCT ≥0. 35 and ≤0. 44,n = 219) and non-standard-reaching group( MAP ≤65 mm Hg or BUN ≥7. 14 mmol/L or HCT > 0. 44 or < 0. 35,n = 226).The standard-reaching group represented normal volume,while the non-standard-reaching group represented insufficient volume. The two groups were compared in terms of symptoms,signs,etiology,severity,complication,and prognosis. The chi-square test or the Fisher's exact test was used for comparison of categorical data between two groups,and the Mann-Whitney U test was used for comparison of continuous data between two groups. Results Compared with the standard-reaching group,the non-standard-reaching group had significant increases in white blood cell count,BUN,and Computed Tomography Severity Index of the pancreas( Z =-2. 85,-6. 725,and-2. 293,all P < 0. 01). As for local complications,compared with the non-standard-reaching group,the standard-reaching group had significantly lower incidence rates of peripancreatic exudation( 45. 2% vs 54. 9%,χ2= 4. 15,P < 0. 05) and pancreatic necrosis( 10. 0% vs 18. 6%,χ2= 6. 59,P < 0. 05). As for systemic complications,compared with the non-standard-reaching group,the standard-reaching group had significantly lower incidence rates of acute respiratory distress syndrome( ARDS)( 0. 5% vs 4. 4%,χ2= 7. 26,P < 0. 05) and renal dysfunction( 1. 4% vs 6. 6%,χ2= 7. 95,P < 0. 05). The standard-reaching group had significantly lower proportion of patients with severe pancreatitis and hospital costs than the non-standard-reaching group( both P < 0. 05). Conclusion Fluid resuscitation endpoints can be used to evaluate the blood volume of patients with acute pancreatitis in the early stage after admission,and the patients not reaching the standard of fluid resuscitation tend to develop the complications such as peripancreatic exudation,pancreatic necrosis,ARDS,and renal dysfunction and may have higher hospital costs.