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Volume 36 Issue 9
Sep.  2020
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Article Navigation >  Journal of Clinical Hepatology  > 2020  >  36(9): 2025-2029

Serum level of ceruloplasmin in patients with different liver diseases in Jilin,China

DOI: 10.3969/j.issn.1001-5256.2020.09.023

  • Department of Hepatology,The First Hospital of Jilin University

  • Department of Cardiology,The First Hospital of Jilin University

  • Department of Anesthesiology,The FAW General Hospital of Jilin Province

Research funding:

 

  • Received Date: 2020-05-17
  • Published Date: 2020-09-20
    Abstract
  • Objective To investigate the serum level of ceruloplasmin in patients with different stages and etiologies of liver diseases.Methods A total of 1077 patients with liver diseases who were hospitalized in Department of Hepatology,The First Hospital of Jilin University,from January 2012 to January 2018 were enrolled,and the serum level of ceruloplasmin was analyzed for the patients with different liver diseases. The Kruskal-Wallis H test was used to compare the level of ceruloplasmin between the patients with virus-related liver diseases with different liver functional states,and a Spearman correlation analysis was used to investigate the correlation of ceruloplasmin with other biomarkers. Results In the Wilson's disease group,97. 6%( 41/42) of the patients had a serum ceruloplasmin level of < 0. 2 g/L and88. 1%( 37/42) had a level of < 0. 1 g/L. In the non-Wilson's disease group,24. 3%( 251/1035) of the patients had a ceruloplasmin level of < 0. 2 g/L and 0. 2% had a level of < 0. 1 g/L. There was a significant difference in the serum level of ceruloplasmin between the patients with virus-related liver diseases with different liver functional states,and the patients with chronic viral hepatitis,severe viral hepatitis,and viral hepatitis cirrhosis had a significantly lower level than those with acute viral hepatitis and virus-related liver cancer( P =0. 005,P < 0. 001,P = 0. 001,P = 0. 027,P < 0. 001,and P = 0. 001). In the patients without Wilson's disease,serum ceruloplasmin was positively correlated with albumin and prealbumin( r = 0. 068 and 0. 091,both P < 0. 05) and was negatively correlated with prothrombin time( r =-0. 297,P < 0. 05). Conclusion Ceruloplasmin often decreases significantly in patients with Wilson's disease,with a slight reduction in patients with other types of liver diseases. For these patients,it should be determined whether the reduction in ceruloplasmin is caused by hepatocyte injury or the presence of Wilson's disease.

     

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