中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 36 Issue 5
May  2020
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Article Contents

Clinical effect of epidermal growth factor receptor-targeted agents in treatment of advanced pancreatic cancer:A Meta-analysis

DOI: 10.3969/j.issn.1001-5256.2020.05.029
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  • Published Date: 2020-05-20
  • Objective To systematically evaluate the clinical effect of epidermal growth factor receptor( EGFR)-targeted agents in the treatment of advanced pancreatic cancer.Methods EMbase, PubMed, Cochrane Library, Clinical Trials, CNKI, Wanfang Data, and VIP were searched for randomized controlled trials(RCTs) of EGFR-targeted therapies for advanced pancreatic cancer. Eligible RCTs were screened out based on quality and related criteria, and RevMan 5.3 and STATA 12.0 were used to perform the meta-analysis.Results A total of 8 RCTs were included, with 2382 patients in total. The results of the meta-analysis showed that compared with the control group,the experimental group had no increases in overall survival time(hazard ratio [HR] =0.86, 95% confidence interval [CI]: 0.74-1.02,P> 0. 05) and objective response rate(risk ratio [RR] = 1. 00, 95% CI: 0. 76-1. 32,P> 0. 05), but had significant increases in progression-free survival time(HR =0.78, 95%CI: 0.62-0.98,P< 0. 05) and disease control rate(RR = 1. 22, 95% CI: 1. 04-1. 43,P< 0. 05). The subgroup analysis showed that after the source of heterogeneity was identified and the studies with high heterogeneity were excluded, the experimental group had a significant increase in overall survival time(HR =0. 85, 95%CI: 0. 77-0. 94,P< 0. 05), and the patients with rash appeared to be more sensitive to the therapies(HR =0.70, 95%CI: 0.54-0.92,P< 0. 05).Conclusion For patients with advanced pancreatic cancer, EGFR-targeted therapies can effectively prolong overall survival time and improve quality of life.

     

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