Value of red blood cell distribution width,mean platelet volume,and neutrophil-lymphocyte ratio in the evaluation of primary biliary cholangitis

Objective To investigate the value of red blood cell distribution width( RDW),mean platelet volume( MPV),platelet distribution width( PDW),lymphocyte-monocyte ratio( LMR),platelet-lymphocyte ratio( PLR),and neutrophil-lymphocyte ratio( NLR)in evaluating the deterioration and progression of primary biliary cholangitis( PBC). Methods A retrospective analysis was performed for the clinical data of 80 patients who were diagnosed with PBC in The First Affiliated Hospital of Shihezi University from December 2015 to March 2019,including liver function and RDW,MPV,and PDW in routine blood test,and NLR,LMR,and PLR were calculated. According to related diagnostic criteria,the patients were divided into PBC liver cirrhosis group and PBC hepatitis group. The independent samples t-test was used for comparison of normally distributed continuous data between groups,and the Mann-Whitney U test was used for comparison of non-normally distributed continuous data between groups. The chi-square test was used for comparison of categorical data between groups. A binary logistic regression analysis was used to investigate the risk factors for PBC liver cirrhosis. The receiver operating characteristic( ROC) curve was plotted to compare the value of different indices in the diagnosis of PBC liver cirrhosis. Results Compared with the PBC hepatitis group,the PBC liver cirrhosis group had a significant reduction in the serum level of white blood cells( Z =-4. 777,P<0. 001) and a significant reduction in the serum level of alanine aminotransferase( Z =-2. 152,P = 0. 031). Compared with the PBC hepatitis group,the PBC liver cirrhosis group had significant increases in RDW,MPV,and NLR( Z =-3. 180,-2. 963,and-3. 590,all P< 0. 05). The binary logistic regression analysis showed that RDW( odds ratio [OR] = 4. 99,95% confidence interval [CI]: 1. 39-17. 92),MPV( OR = 13. 01,95% CI: 2. 96-57. 07),and NLR( OR = 4. 45,95% CI: 1. 59-12. 40) were independent risk factors for progression to liver cirrhosis in PBC patients,for the diagnosis of which RDW,MPV,and NLR had an area under the ROC curve of 0. 683,0. 667,and 0. 741,respectively,while the combination of these three indices had an area under the ROC curve of 0. 891. Conclusion In-creases in RDW,MPV,and NLR may indicate the progression to liver cirrhosis in PBC patients and thus have a certain value in predicting malignant progression in PBC patients.