中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 35 Issue 10
Oct.  2019
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Article Contents

Role of autoimmune ecological factors in the pathogenesis of autoimmune hepatitis

DOI: 10.3969/j.issn.1001-5256.2019.10.046
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  • Received Date: 2019-05-27
  • Published Date: 2019-10-20
  • Autoimmune hepatitis(AIH) is a chronic liver inflammatory disease with unknown etiology,and at present,both genetic and environmental factors are thought to be involved in the pathogenesis of AIH. Environmental exposure has an important impact on the development of AIH. Autoimmune ecology is the study of the interactions between individuals and their environment,the development of imbalance between individuals and environment,and the mechanism of such imbalance in promoting the development of autoimmune disease. This article reviews the research advances in the role of autoimmune ecology in the pathogenesis of AIH.

     

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  • [1] Chinese Society of Hepatology,Chinese Medical Association;Chinese Society of Gastroenterology,Chinese Medicalassociation; Chinese Society of Infectious Diseases,Chinese Medical Association. Chinese consensus on the diagnosis and management of autoimmune hepatitis(2015)[J]. J Clin Hepatol,2016,32(1):9-22.(in Chinese)中华医学会肝病学分会,中华医学会消化病学分会,中华医学会感染病学分会.自身免疫性肝炎诊断和治疗共识(2015)[J].临床肝胆病杂志,2016,32(1):9-22.
    [2] ANAYA JM,RAMIREZ-SANTANA C,ALZATE MA,et al. The auto immune ecology[J]. Front Immunol,2016,7:139.
    [3] DOHERTY DG. Immunity,tolerance and autoimmunity in the liver:A comprehensive review[J]. J Autoimmun,2016,66:60-75.
    [4] CHOI J,SELMI C,LEUNG PS,et al. Chemokine and chemokine receptors in autoimmunity:The case of primary biliary cholangitis[J]. Expet Rev Clin Immunol,2016,12(6):661-672.
    [5] RIAZ A,ILAN N,VLODAVSKY I,et al. Characterization of heparinase induced phosphatidylinositol 3-kinase-AKT activation and its integrin dependence[J]. J Biol Chem,2013,288(17):12366-12375.
    [6] ADEOYE GO,ALIMBA CG,OYELEKE OB. The genotoxicity and systemic toxicity of a pharmaceutical effluent in Wistar rats may involve oxidative stress induction[J]. Toxicology Reports,2015,2:1265-1272.
    [7] ARNDTZ K,HIRSCHFIELD GM. The pathogenesis of autoimmune liver disease[J]. Dig Dis,2016,34(4):327–333.
    [8] CUSICK MF,LIBBEY JE,FUJINAMI RS. Molecular mimicry as a mechanism of autoimmune disease[J]. Clin Rev Allergy Immunol,2012,42(1):102-111.
    [9] ANAYA JM,RESTREPO-JIMNEZ P,RAMREZ-SANTANA C. The autoimmune ecology:An update[J]. Curr Opin Rheumatol,2018,30(4):350-360.
    [10] CHEN J,ZHANG J,HE QS. Role of Toll-like receptors in development and progression of nonalcoholic fatty liver disease[J]. J Clin Hepatol,2015,31(7):1153-1155.(in Chinese)陈杰,张晶,何秋水. Toll样受体在非酒精性脂肪性肝病发生发展中的作用[J].临床肝胆病杂志,2015,31(7):1153-1155.
    [11] CZAJA AJ. Factoring the intestinal microbiome into the pathogenesis of autoimmune hepatitis[J]. World J Gastroenterol,2016,22(42):9257-9278.
    [12] HUANG CY,CHEN J,LIU YM,et al. Role of intestinal flora in the development/progression and treatment of autoimmune liver diseases[J]. J Clin Hepatol,2019,35(1):52-54.(in Chinese)黄春洋,陈杰,刘燕敏,等.肠道菌群在自身免疫性肝病发生发展及治疗中的作用[J].临床肝胆病杂志,2019,35(1):52-54.
    [13] LIN R,ZHOU L,ZHANG J,et al. Abnormal intestinal permeability and microbiota in patients with autoimmune hepatitis[J].Int. J Clin Exp Pathol,2015,8(5):5153-5160.
    [14] VENTO S,GAROFANO T,DI PERRI G,et al. Identification of hepatitis A virus as a trigger for autoimmune chronic hepatitistype 1 in susceptible individuals[J]. Lancet,1991,337(8751):1183-1187.
    [15] FLOREANI A,RESTREPO-JIMNEZ P,SECCHI MF,et al.Etiopathogenesis of autoimmune hepatitis[J]. J Autoimmun,2018,95(12):133-143.
    [16] VERGANI D,MIELI-VERGANI G. Autoimmune manifestations in viral hepatitis[J]. Semin Immunopathol,2013,35(1):73-85.
    [17] BADIANI RG,BECKER V,PEREZ RM,et al. Is autoimmune hepatitis a frequent finding among HCV patients with intense interface hepatitis?[J]. World J Gastroenterol,2010,16(29):3704-3708.
    [18] TAUBERT R,DIESTELHORST J,JUNGE N,et al. Increased seroprevalence of HAV and parvovirus B19 in children and of HEV in adults at diagnosis of autoimmune hepatitis[J]. Sci Rep,2018,8(1):17452.
    [19] PAIARDINI A,PASCARELLA S. Structural mimicry between SLA/LP and Rickettsia surface antigens as a driver of autoimmune hepatitis:Insights from an in silico study[J]. Theor Biol Med Model,2013,10(3):25.
    [20] TUNCCAN OG,TUFAN A,TELLI G,et al. Visceral leishmaniasis mimicking autoimmune hepatitis,primary biliary cirrhosis,and systemic lupus erythematosus overlap[J]. Korean J Parasitol,2012,50(2):133-136.
    [21] THIELE GM,DURYEE MJ,WILLIS MS,et al,Autoimmune hepatitis induced by syngeneic liver cytosolic proteins biotransformed by alcohol metabolites[J]. Alcohol Clin Exp Res,2010,34(12):2126-2136.
    [22] COLOTTA F,JANSSON B,BONELLI F. Modulation of inflammatory and immune responses by vitamin D[J]. J Autoimmun,2017,85(12):78-97.
    [23] LUONG KV,NGUYEN LT. The role of vitamin D in autoimmune hepatitis[J]. J Clin Med Res,2013,5(6):407-415.
    [24] EFE C,KAV T,AYDIN C,et al. Low serum vitamin D levels are associated with severe histological features and poor response to therapy in patients with autoimmune hepatitis[J].Dig Dis Sci,2014,59(12):3035-3042.
    [25] HE Y,ZHAN J. Advances in drug-induced autoimmune hepatitis[J]. J Prac Hepatol,2013,16(2):178-180.(in Chinese)何艳,詹俊.药物诱导的自身免疫性肝炎研究进展[J].实用肝脏病杂志,2013,16(2):178-180.
    [26] DELEMOS AS,FOUREAU DM,JACOBS C,et al. Drug-induced liver injury with autoimmune features[J]. Semin Liver Dis,2014,34(2):194-204.
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