中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 35 Issue 9
Sep.  2019
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Article Contents

Regulatory role of microRNA in aerobic glycolysis in hepatocellular carcinoma

DOI: 10.3969/j.issn.1001-5256.2019.09.044
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  • Received Date: 2019-05-20
  • Published Date: 2019-09-20
  • Glucose metabolism recombination is an important marker of hepatocellular carcinoma ( HCC) , and cancer cells can quickly adjust their energy sources from mitochondrial oxidative phosphorylation to glycolysis to meet the need of efficient proliferation in the hypoxic environment. In recent years, more and more studies have shown that post-transcriptional regulation of microRNAs ( miRNAs) plays a key role in the fine regulation of metabolic reprogramming, which is closely associated with the clinicopathological features, development, and progression of HCC. There are various influencing factors for glycolysis, and therefore, this article reviews the influence of abnormal expression of miRNAs on the direct and indirect regulation of aerobic glycolysis in HCC, in order to provide a theoretical basis for the early diagnosis, targeted treatment, and prognostic evaluation of HCC.

     

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