Establishment of the diagnostic criteria and hierarchical diagnosis and treatment system for acute-on-chronic liver failure based on high-quality Chinese evidence

Establishment of a hierarchical diagnosis and treatment system for patients with acute exacerbation of chronic liver diseases based on Chinese clinical evidence and development of the diagnostic criteria for acute-on-chronic liver failure ( ACLF) in HBV epidemic areas based on high-quality Chinese evidence provide great opportunities for China to make breakthroughs in the field of severe liver diseases and utter the Chinese voice around the world. Whether the same diagnostic criteria for ACLF can be used in patients with liver diseases as primary diseases with ( liver cirrhosis and nonalcoholic steatohepatitis) or without ( non-cirrhotic chronic hepatitis B) systemic organ injury is the key to the development of the diagnostic criteria for ACLF in HBV epidemic areas. This article introduces the global cooperation between EASL-CLIF Consortium, South America CLIF Consortium, and Chinese CLIF Consortium.