中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 35 Issue 3
Mar.  2019
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Article Contents

Influence of drinking on progression of chronic hepatitis B and outcome of antiviral therapy

DOI: 10.3969/j.issn.1001-5256.2019.03.003
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  • Received Date: 2019-01-14
  • Published Date: 2019-03-20
  • HBV can interact with alcohol in various ways to cause liver damage. Heavy drinking can accelerate the progression of chronichepatitis B and lead to a poorer prognosis; meanwhile, it can also affect the outcome and compliance in patients receiving antiviral therapy.The epidemiology of drinking in patients with chronic hepatitis B in China remains unclear, and further studies are needed to clarify themechanism of interaction between alcohol and HBV. Drinking management should be strengthened in patients with chronic hepatitis B inclinical practice, in order to alleviate liver injury induced by alcohol.

     

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  • [1] Polaris Observatory Collaborators. Global prevalence, treat-ment, and prevention of hepatitis B virus infection in 2016:Amodelling study[J]. Lancet Gastroenterol Hepatol, 2018, 3 (6) :383-403.
    [2] WHO. Global status report on alcohol and health 2018[EB/OL]. Geneva:World Health Organization, 2018.
    [3] YAN J, XIE W, OU WN, et al. Epidemiological survey and riskfactor analysis of fatty liver disease of adult residents, Beijing, China[J]. J Gastroenterol Hepatol, 2013, 28 (10) :1654-1659.
    [4] YI YH, KIM YJ, LEE SY, et al. Health behaviors of Korean a-dults with hepatitis B:Findings of the 2016 Korean NationalHealth and Nutrition Examination Survey[J]. World J Gastro-enterol, 2018, 24 (28) :3163-3170.
    [5] PARK B, JUNG KW, OH CM, et al. Factors associated withalcohol consumption in hepatitis B carriers:A nationwide studyin the Republic of Korea[J]. PLo S One, 2014, 9 (11) :e110144.
    [6] VINIKOOR MJ, ZYAMBO Z, MUYOYETA M, et al. Point-of-care urine ethyl glucuronide testing to detect alcohol use a-mong HIV-hepatitis B virus coinfected adults in Zambia[J].AIDS Behav, 2018, 22 (7) :2334-2339.
    [7] VATANSEVER S, PAKOZ ZB, UNSAL B. Evaluation of hepatitisA, B, and C serology in patients with cirrhosis and intensive alco-hol consumption[J]. North Clin Istanb, 2018, 5 (2) :109-113.
    [8] SCHMIDT CS, SCHN D, SCHULTE B, et al. Viral hepatitis inalcohol-dependent inpatients:Prevalence, risk factors, andtreatment uptake[J]. J Addict Med, 2013, 7 (6) :417-421.
    [9] LIN CW, LIN CC, MO LR, et al. Heavy alcohol consumptionincreases the incidence of hepatocellular carcinoma in hepatitisB virus-related cirrhosis[J]. J Hepatol, 2013, 58 (4) :730-735.
    [10] LYU X, LIU K, CHEN Y, et al. Analysis of risk factors associ-ated with the development of hepatocellular carcinoma in chro-nic HBV-infected Chinese:A meta-analysis[J]. Int J Envi-ron Res Public Health, 2016, 13 (6) :e604.
    [11] CHEN CJ, YANG HI, SU J, et al. Risk of hepatocellular carci-noma across a biological gradient of serum hepatitis B virusDNA level[J]. JAMA, 2006, 295 (1) :65-73.
    [12] STROFFOLINI T, COTTICELLI G, MEDDA E, et al. Interactionof alcohol intake and cofactors on the risk of cirrhosis[J]. Liv-er Int, 2010, 30 (6) :867-870.
    [13] ONG A, WONG VW, WONG GL, et al. The effect of caffeineand alcohol consumption on liver fibrosis-a study of 1045 A-sian hepatitis B patients using transient elastography[J]. LiverInt, 2011, 31 (7) :1047-1053.
    [14] IIDA-UENO A, ENOMOTO M, TAMORI A, et al. Hepatitis Bvirus infection and alcohol consumption[J]. World J Gastroen-terol, 2017, 23 (15) :2651-2659.
    [15] European Association for the Study of the Liver. EASL clinicalpractice guidelines:Management of alcohol-related liver dis-ease[J]. J Hepatol, 2018, 69 (1) :154-181.
    [16] TEKIN F, GUNSAR F, ERDOGAN EI, et al. Seroprevalence ofhepatitis A, B, and C viruses in Turkish alcoholic cirrhotics andthe impact of hepatitis B on clinical profile[J]. J Infect DevCtries, 2015, 9 (3) :254-258.
    [17] KWON OS, JUNG YK, KIM YS. Effect of alcohol on the devel-opment of hepatocellular carcinoma in patients with hepatitis Bvirus-related cirrhosis:A cross-sectional case-controlstudy[J]. Korean J Hepatol, 2010, 16 (3) :308-314.
    [18] ZHANG M, WU R, JIANG J, et al. The presence of hepatitis Bcore antibody is associated with more advanced liver diseasein alcoholic patients with cirrhosis[J]. Alcohol, 2013, 47 (7) :553-538.
    [19] FUSTER D, SAMET JH. Alcohol use in patients with chronicliver disease[J]. N Engl J Med, 2018, 379 (13) :1251-1261.
    [20] MANSOURI A, GATTOLLIAT CH, ASSELAH T. Mitochondrialdysfunction and signaling in chronic liver diseases[J]. Gas-troenterology, 2018, 155 (3) :629-647.
    [21] ZHENG H, LI P, KWOK JG, et al. Alcohol and hepatitis virus-dysregulated lncRNAs as potential biomarkers for hepatocel-lular carcinoma[J]. Oncotarget, 2018, 9 (1) :224-235.
    [22] HUANG JJ, LIU SK, LI ZJ, et al. Effect of lamivudine and sily-marin on liver fibrosis-relevant factors in HBV transgenic micewith alcohol drinking[J]. J Cent South Univ:Med Sci, 2017, 42 (3) :257-263. (in Chinese) 黄娟娟, 刘世坤, 李佐军, 等.拉米夫定和水飞蓟素对酒精刺激的HBV转基因小鼠肝纤维化相关因子的影响[J].中南大学学报:医学版, 2017, 42 (3) :257-263.
    [23] LARKIN J, CLAYTON MM, LIU J, et al. Chronic ethanol con-sumption stimulates hepatitis B virus gene expression and rep-lication in transgenic mice[J]. Hepatology, 2001, 34 (4) :792-797.
    [24] MIN BY, KIM NY, JANG ES, et al. Ethanol potentiates hepati-tis B virus replication through oxidative stress-dependent and-independent transcriptional activation[J]. Biochem BiophysRes Commun, 2013, 431 (1) :92-97.
    [25] KIM WH, HONG F, JARUGA B, et al. Additive activation ofhepatic NF-kappaB by ethanol and hepatitis B protein X (HBX) or HCV core protein:Involvement of TNF-alpha re-ceptor 1-independent and-dependent mechanisms[J].FASEB J, 2001, 15 (13) :2551-2553.
    [26] WANG Y, WU T, HU D, et al. Intracellular hepatitis B virus in-creases hepatic cholesterol deposition in alcoholic fatty liver viahepatitis B core protein[J]. J Lipid Res, 2018, 59 (1) :58-68.
    [27] STROFFOLINI T, SAGNELLI E, ANDRIULLI A, et al. Sex differ-ence in the interaction of alcohol intake, hepatitis B virus, andhepatitis C virus on the risk of cirrhosis[J]. PLo S One, 2017, 12 (11) :e0185710.
    [28] SPRADLING PR, BULKOW L, TESHALE EH, et al. Prevalenceand causes of elevated serum aminotransferase levels in apopulation-based cohort of persons with chronic hepatitis Bvirus infection[J]. J Hepatol, 2014, 61 (4) :785-791.
    [29] STAUFER K, HUBER-SCHNAUER U, OBERNDORF K, etal. The long-term alcohol parameter ethyl glucuronide in hairuncovers a high rate of alcoholic liver disease patients falselydiagnosed as non-alcoholic fatty liver disease[J]. Hepatolo-gy, 2018, 68 (S1) :979A.
    [30] PAPATHEODORIDIS GV, TSOCHATZIS E, HARDTKE S, et al.Barriers to care and treatment for patients with chronic viralhepatitis in Europe:A systematic review[J]. Liver Int, 2014, 34 (10) :1452-1463.
    [31] HSU CC, KOWDLEY KV. The effects of alcohol on other chro-nic liver diseases[J]. Clin Liver Dis, 2016, 20 (3) :581-594.
    [32] CHUNG WG, KIM HJ, CHOE YG, et al. Clinical impacts ofhazardous alcohol use and obesity on the outcome of ente-cavir therapy in treatment-nave patients with chronic hepati-tis B infection[J]. Clin Mol Hepatol, 2012, 18 (2) :195-202.
    [33] CHEN J, WANG ML, LONG Q, et al. High value of controlledattenuation parameter predicts a poor antiviral response in pa-tients with chronic hepatits B[J]. Hepatobiliary Pancreat DisInt, 2017, 16 (4) :370-374.
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