中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 11
Nov.  2017
Turn off MathJax
Article Contents

Research advances in the mouse model of primary biliary cholangitis

DOI: 10.3969/j.issn.1001-5256.2017.11.041
Research funding:

 

  • Received Date: 2017-08-22
  • Published Date: 2017-11-20
  • Primary biliary cholangitis (PBC) is an autoimmune disease characterized by the destruction of interlobular bile ducts and infiltration of inflammatory factors.An increase in anti-mitochondrial antibody is the major feature of PBC and may eventually lead to intrahepatic cholestasis, liver fibrosis, and even liver cirrhosis.The pathogenesis of this disease remains unclear, and there is no ideal treatment regimen.Therefore, it is necessary to find an animal model matching with PBC, in order to study the pathogenesis, treatment, and prognosis of PBC.This article introduces the research advances in bile duct ligation models, drug models, antigen models, gene models, and spontaneous models, in order to summarize the features and limitations of the mouse model of PBC in the articles published in recent years and provide a basis for the selection and research of PBC models.

     

  • loading
  • [1]JUNGST C, BERG T, CHENG J, et al.Intrahepatic cholestasis in common chronic liver diseases[J].Eur J Clin Invest, 2013, 43 (10) :1069-1083.
    [2]KAR SP, SELDIN MF, CHEN W, et al.Pathway-based analysis of primary biliary cirrhosis genome-wide association studies[J].Genes Immun, 2013, 14 (3) :179-186.
    [3]LEUNG PS, WANG J, NAIYANETR P, et al.Environment and primary biliary cirrhosis:electrophilic drugs and the induction of AMA[J].J Autoimmun, 2013, 41:79-86.
    [4]IMAM MH, LINDOR KD.The natural history of primary biliary cirrhosis[J].Semin Liver Dis, 2014, 34 (3) :329-333.
    [5]ZHANG ZY, WANG YP, ZHOU YN.Advances in diagnosis and treatment of primary biliary cholangitis[J].J Clin Hepatol, 2016, 32 (10) :2016-2020. (in Chinese) 张臻英, 王玉平, 周永宁.原发性胆汁性胆管炎诊治进展[J].临床肝胆病杂志, 2016, 32 (10) :2016-2020.
    [6]DUWAERTS CC, GEHRING S, CHENG CW, et al.Contrasting responses of Kupffer cells and inflammatory mononuclear phagocytes to biliary obstruction in a mouse model of cholestatic liver injury[J].Liver Int, 2013, 33 (2) :255-265.
    [7]ALLER MA, ARIAS JL, PRIETO I, et al.Bile duct ligation:step-by-step to cholangiocyte inflammatory tumorigenesis[J].Eur JGastroenterol Hepatol, 2010, 22 (6) :651-661.
    [8]WAKABAYASHI K, LIAN ZX, LEUNG PS, et al.Loss of tolerance in C57BL/6 mice to the autoantigen E2 subunit of pyruvate dehydrogenase by a xenobiotic with ensuing biliary ductular disease[J].Hepatology, 2008, 48 (2) :531-540.
    [9]FICKERT P, STOGER U, FUCHSBICHLER A, et al.A new xenobiotic-induced mouse model of sclerosing cholangitis and biliary fibrosis[J].Am J Pathol, 2007, 171 (2) :525-536.
    [10]OKADA C, AKBAR SM, HORIIKE N, et al.Early development of primary biliary cirrhosis in female C57BL/6 mice because of poly I∶Cadministration[J].Liver Int, 2005, 25 (3) :595-603.
    [11]GUO XX, LI LX, WU YP, et al.Establishment of a mouse model of early primary biliary cirrhosis by polyinosinic-polycytidylic acid[J].J Pract Hepatol, 2014, 17 (6) :619-622. (in Chinese) 郭晓霞, 李良学, 武玉鹏, 等.聚肌胞苷酸诱导的早期原发性胆汁性肝硬化小鼠模型的建立[J].实用肝脏病杂志, 2014, 17 (6) :619-622.
    [12]SONG G, HU C, ZHU H, et al.Comparative proteomics study on liver mitochondria of primary biliary cirrhosis mouse model[J].BMC Gastroenterol, 2013, 13:64.
    [13]AMBROSINI YM, YANG GX, ZHANG W, et al.The multi-hit hypothesis of primary biliary cirrhosis:polyinosinic-polycytidylic acid (poly I∶C) and murine autoimmune cholangitis[J].Clin Exp Immunol, 2011, 166 (1) :110-120.
    [14]PADGETT KA, SELMI C, KENNY TP, et al.Phylogenetic and immunological definition of four lipoylated proteins from Novosphingobium aromaticivorans, implications for primary biliary cirrhosis[J].J Autoimmun, 2005, 24 (3) :209-219.
    [15]MATTNER J, SAVAGE PB, LEUNG P, et al.Liver autoimmunity triggered by microbial activation of natural killer T cells[J].Cell Host Microbe, 2008, 3 (5) :304-315.
    [16]WANG J, SHAN Y, JIANG Z, et al.High frequencies of activated B cells and T follicular helper cells are correlated with disease activity in patients with new-onset rheumatoid arthritis[J].Clin Exp Immunol, 2013, 174 (2) :212-220.
    [17]WANG JJ, YANG GX, ZHANG WC, et al.Escherichia coli infection induces autoimmune cholangitis and anti-mitochondrial antibodies in non-obese diabetic (NOD) .B6 (Idd10/Idd18) mice[J].Clin Exp Immunol, 2014, 175 (2) :192-201.
    [18]BOGDANOS DP, BAUM H, GRASSO A, et al.Microbial mimics are major targets of crossreactivity with human pyruvate dehydrogenase in primary biliary cirrhosis[J].J Hepatol, 2004, 40 (1) :31-39.
    [19]XU Y, WANG JB, WANG S, et al.Association between chronic urinary tract infection and primary biliary cirrhosis[J].Chin J Hepatol, 2016, 24 (6) :478-480 (in Chinese) 徐严, 王江滨, 王颂, 等.慢性泌尿系感染与原发性胆汁性肝硬化的关系[J].中华肝脏病杂志, 2016, 24 (6) :478-480.
    [20]JIANG XH, ZHONG RQ, FANG XY, et al.Establishment of a mouse model of primary biliary cirrhosis by AMA M2 autoantigen injection[J].Chin J Hepatol, 2006, 14 (3) :202-204. (in Chinese) 姜小华, 仲人前, 方晓云, 等.抗线粒体抗体M2抗原诱导小鼠原发性胆汁性肝硬化模型的建立[J].中华肝脏病杂志, 2006, 14 (3) :202-204.
    [21] BOGDANOS DP, BAUM H, GRASSO A, et al.Microbial mimics are major targets of crossreactivity with human pyruvate dehydrogenase in primary biliary cirrhosis[J].J Hepatol, 2004, 40 (1) :31-39.
    [22]YANG GX, LIAN ZX, CHUANG YH, et al.Adoptive transfer of CD8 (+) T cells from transforming growth factor beta receptor type II (dominant negative form) induces autoimmune cholangitis in mice[J].Hepatology, 2008, 47 (6) :1974-1982.
    [23]BERNUZZI F, FENOGLIO D, BATTAGLIA F, et al.Phenotypical and functionalalterations of CD8 regulatory T cells in primary biliary cirrhosis[J].J Autoimmun, 2010, 35 (3) :176-180.
    [24]FENOGLIO D, BERNUZZI F, BATTAGLIA F, et al.Th17 and regulatory T lymphocytes in primary biliary cirrhosis and systemic sclerosis as models of autoimmune fibrotic diseases[J].Autoimmun Rev, 2012, 12 (2) :300-304.
    [25]OERTELT S, LIAN ZX, CHENG CM, et al.Anti-mitochondrial antibodies and primary biliary cirrhosis in TGF-beta receptor IIdominant-negative mice[J].J Immunol, 2006, 177 (3) :1655-1660.
    [26]KOARADA S, WU Y, CHENG CM, et al.Genetic control of autoimmunity:protection from diabetes, but spontaneous autoimmune biliary disease in a nonobese diabetic congenic strain[J].J Immunol, 2004, 173 (4) :2315-2323.
    [27]IRIE J, WU Y, WICKER LS, et al.NOD.c3c4 congenic mice develop autoimmune biliary disease that serologically and pathogenetically models human primary biliary cirrhosis[J].Exp Med, 2006, 203 (5) :1209-1219.
    [28]KATSUMI T, TOMITA K, LEUNG PS, et al.Animal models of primary biliary cirrhosis[J].Clin Rev Allergy Immunol, 2015, 48 (2-3) :142-153.
    [29]MORITOKI Y, TSUDA M, TSUNEYAMA K, et al.B cells promote hepatic inflammation, biliary cyst formation, and salivary gland inflammation in the NOD.c3c4 model of autoimmune cholangitis[J].Cell Immunol, 2011, 268 (1) :16-23.
    [30]YAO Y, YANG W, YANG YQ, et al.Distinct from its canonical effects, deletion of IL-12p40 induces cholangitis and fibrosis in interleukin-2Ralpha (-/-) mice[J].J Autoimmun, 2014, 51 (4) :99-108.
    [31]HSU W, ZHANG W, TSUNEYAMA K, et al.Differential mechanisms in the pathogenesis of autoimmune cholangitis versus inflammatory bowel disease in interleukin-2Ralpha (-/-) mice[J].Hepatology, 2009, 49 (1) :133-140.
    [32]LLEO A, OERTELT-PRIGIONE S, BIANCHI I, et al.Y chromosome loss in male patients with primary biliary cirrhosis[J].JAutoimmun, 2013, 41:87-91.
    [33]CHEN XM, O'HARA SP, LARUSSO NF, et al.The immunobiology of cholangiocytes[J].Immunol Cell Biol, 2008, 86 (6) :497-505.
    [34]SALAS JT, BANALES JM, SARVIDE S, et al.Ae2a, b-deficient mice develop antimitochondrial antibodies and other features resembling primary biliary cirrhosis[J].Gastroenterology, 2008, 134 (5) :1482-1493.
    [35]LLEO A, ZHANG W, ZHAO M, et al.DNA methylation profiling of the X chromosome reveals an aberrant demethylation on CXCR3promoter in primary biliary cirrhosis[J].Clin Epigenetics, 2015, 7 (1) :61.
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Article Metrics

    Article views (1716) PDF downloads(454) Cited by()
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return