中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 9
Sep.  2017
Turn off MathJax
Article Contents

Role of DNA recognition receptors in pathogenic mechanism of hepatitis B

DOI: 10.3969/j.issn.1001-5256.2017.09.037
Research funding:

 

  • Published Date: 2017-09-20
  • As a global disease, hepatitis B still threatens human health. However, the pathogenesis of hepatitis caused by HBV remains unclear. The innate immune system in the liver can detect HBV infection and use every strategy to eliminate the virus. DNA recognition receptors play an important role in this process; they recognize HBV DNA or pgRNA in cytoplasm or nucleus, activate innate immunity through various signaling pathways to produce inflammatory cytokines and interferon, and finally exert their antiviral effect. This article summarizes the DNA recognition receptors involved in inflammation induced by HBV and HBV clearance, elaborates on their detailed pathways, and discusses the issues regarding the role of DNA recognition receptors in liver innate immunity induced by HBV and related perspectives.

     

  • loading
  • [1]GONZALEZ SA, KEEFFE EB.Chronic viral hepatitis:epidemiology, molecular biology, and antiviral therapy[J].Front Biosci (Landmark Ed) , 2011, 16:225-250.
    [2]FARAZI PA, DEPINHO RA.Hepatocellular carcinoma pathogenesis:from genes to environment[J].Nat Rev Cancer, 2006, 6 (9) :674-687.
    [3] FU WZ, YANG L, HU XQ.Relationship between HBV DNA load and HBV-M, ALT, AST content in the serum of chronic hepatitis B patients[J].Int J Virol, 2015, 22 (2) :111-114. (in Chinese) 付万智, 杨丽, 胡晓勤.慢性乙肝患者血清HBV DNA载量与HBV-M、ALT、AST含量的关系研究[J].国际病毒学杂志, 2015, 22 (2) :111-114.
    [4]BUSCA A, KUMAR A.Innate immune responses in hepatitis B virus (HBV) infection[J].Virol J, 2014, 11:22.
    [5]HORNUNG V, ELLEGAST J, KIM S, et al.5'-Triphosphate RNA is the ligand for RIG-I[J].Science, 2006, 314 (5801) :994-997.
    [6]HEMMI H, TAKEUCHI O, KAWAI T, et al.A Toll-like receptor recognizes bacterial DNA[J].Nature, 2000, 408 (6813) :740-745.
    [7]DEMPSEY A, BOWIE AG.Innate immune recognition of DNA:a recent history[J].Virology, 2015, 479-480:146-152.
    [8]PALUDAN SR.Activation and regulation of DNA-driven immune responses[J].Microbiol Mol Biol Rev, 2015, 79 (2) :225-241.
    [9]TAKEUCHI O, AKIRA S.Pattern recognition receptors and inflammation[J].Cell, 2010, 140 (6) :805-820.
    [10]WU J, CHEN ZJ.Innate immune sensing and signaling of cytosolic nucleic acids[J].Annu Rev Immunol, 2014, 32:461-488.
    [11]REVILL P, YUAN Z.New insights into how HBV manipulates the innate immune response to establish acute and persistent infection[J].Antivir Ther, 2013, 18 (1) :1-15.
    [12]BRCKSTMMER T, BAUMANN C, BLML S, et al.An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome[J].Nat Immunol, 2009, 10 (3) :266-272.
    [13]FERNANDES-ALNEMRI T, YU JW, DATTA P, et al.AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA[J].Nature, 2009, 458 (7237) :509-513.
    [14]HORNUNG V, ABLASSER A, CHARREL-DENNIS M, et al.AIM2 recognizes cytosolic ds DNA and forms a caspase-1-activating inflammasome with ASC[J].Nature, 2009, 458 (7237) :514-518.
    [15]RATHINAM VA, JIANG Z, WAGGONER SN, et al.The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNAviruses[J].Nat Immunol, 2010, 11 (5) :395-402.
    [16]MORRONE SR, MATYSZEWSKI M, YU X, et al.Assemblydriven activation of the AIM2 foreign-ds DNA sensor provides a polymerization template for downstream ASC[J].Nat Commun, 2015, 6:7827.
    [17]PANG XQ, LI XH, MO ZS, et al.Expression of absent in melanoma 2 in the liver and correlation with the degrees of liver damage in patients with chronic hepatitis B[J/CD].Chin J Exp Clin Infect Dis:Electronic Edition, 2015, 9 (3) :326-330. (in Chinese) 庞秀青, 李新华, 莫志硕, 等.慢性乙型肝炎患者肝组织中黑色素瘤缺乏因子2表达与病变程度的相关性[J/CD].中华实验和临床感染病杂志:电子版, 2015, 9 (3) :326-330.
    [18]PAN X, XU H, ZHENG C, et al.Human hepatocytes express absent in melanoma 2 and respond to hepatitis B virus with interleukin-18 expression[J].Virus Genes, 2016, 52 (4) :445-452.
    [19]CIVRIL F, DEIMLING T, de OLIVEIRA MANN CC, et al.Structural mechanism of cytosolic DNA sensing by c GAS[J].Nature, 2013, 498 (7454) :332-337.
    [20]ZHANG X, WU J, DU F, et al.The cytosolic DNA sensor c GASforms an oligomeric complex with DNA and undergoes switch-like conformational changes in the activation loop[J].Cell Rep, 2014, 6 (3) :421-430.
    [21] ISHIKAWA H, MA Z, BARBER GN.STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity[J].Nature.2009, 461 (7265) :788-792.
    [22]DANSAKO H, UEDA Y, OKUMURA N, et al.The cyclic GMP-AMP synthetase-STING signaling pathway is required for both the innate immune response against HBV and the suppression of HBV assembly[J].FEBS J, 2016, 283 (1) :144-156.
    [23]TAKAOKA A, WANG Z, CHOI MK, et al.DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response[J].Nature, 2007, 448 (7152) :501-505.
    [24]KAISER WJ, UPTON JW, MOCARSKI ES.Receptor-interacting protein homotypic interaction motif-dependent control of NF-kappa B activation via the DNA-dependent activator of IFN regulatory factors[J].J Immunol, 2008, 181 (9) :6427-6434.
    [25]WANG QJ, LI SB, HUANG HP, et al.Effect of the cytoplasmic DNA sensor DAI on replication of hepatitis B virus[J].Chin JHepatol, 2015, 23 (12) :934-938. (in Chinese) 王秋景, 李世波, 黄红平, 等.胞质内DNA依赖的干扰素调节因子激活物在HBV复制中的作用[J].中华肝脏病杂志, 2015, 23 (12) :934-938.
    [26]UPTON JW, KAISER WJ, MOCARSKI ES.DAI/ZBP1/DLM-1complexes with RIP3 to mediate virus-induced programmed necrosis that is targeted by murine cytomegalovirus v IRA[J].Cell Host Microbe, 2012, 11 (3) :290-297.
    [27]FERGUSON BJ, MANSUR DS, PETERS NE, et al.DNA-PK is a DNA sensor for IRF-3-dependent innate immunity[J].Elife, 2012, 1:e47.
    [28]LI Y, WU Y, ZHENG X, et al.Cytoplasm-translocated Ku70/80complex sensing of HBV DNA induces hepatitis-associated chemokine secretion[J].Front Immunol, 2016, 7:569.
    [29]ZHANG X, BRANN TW, ZHOU M, et al.Cutting edge:Ku70 is a novel cytosolic DNA sensor that induces type III rather than type IIFN[J].J Immunol, 2011, 186 (8) :4541-4545.
    [30]SANCHOOLI J, SANADGOL N, KAZEMI ARABABADI M, et al.CCR5 plays important roles in hepatitis B infection[J].Viral Immunol, 2014, 27 (1) :2-6.
    [31]SAITO T, OWEN D M, JIANG F, et al.Innate immunity induced by composition-dependent RIG-I recognition of hepatitis C virus RNA[J].Nature, 2008, 454 (7203) :523-527.
    [32]WIELAND S, THIMME R, PURCELL RH, et al.Genomic analysis of the host response to hepatitis B virus infection[J].Proc Natl Acad Sci U S A, 2004, 101 (17) :6669-6674.
    [33]NAKAGAWA S, HIRATA Y, KAMEYAMA T, et al.Targeted induction of interferon-λin humanized chimeric mouse liver abrogates hepatotropic virus infection[J].PLo S One, 2013, 8 (3) :e59611.
    [34]SATO S, LI K, KAMEYAMA T, et al.The RNA sensor RIG-Idually functions as an innate sensor and direct antiviral factor for hepatitis B virus[J].Immunity, 2015, 42 (1) :123-132.
    [35]KERUR N, VEETTIL MV, SHARMA-WALIA N, et al.IFI16acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi Sarcoma-associated herpesvirus infection[J].Cell Host Microbe, 2011, 9 (5) :363-375.
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Article Metrics

    Article views (1444) PDF downloads(381) Cited by()
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return