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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 8
Aug.  2017
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Article Contents

Role of ceramide in development and progression of nonalcoholic fatty liver disease

DOI: 10.3969/j.issn.1001-5256.2017.08.038
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  • Received Date: 2017-01-22
  • Published Date: 2017-08-20
  • Nonalcoholic fatty liver disease ( NAFLD) is a clinicopathological syndrome caused by liver damage factors except alcohol and has the major feature of diffuse macrovesicular hepatocyte steatosis. The " two-hit " hypothesis can partly explain the pathogenesis of NAFLD. Recent studies have found that ceramide is a key molecular messenger involved in the development and progression of NAFLD, and as a sphingolipid, it is closely associated with the " two-hit" hypothesis. This article reviews the role of ceramide in NAFLD.

     

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