中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 6
Jun.  2017
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Liver cirrhosis and the risk of fracture: a Meta-analysis

DOI: 10.3969/j.issn.1001-5256.2017.06.019
  • Published Date: 2017-06-20
  • Objective To investigate the association between liver cirrhosis and the risk of fracture from the perspective of evidence-based medicine. Methods Pub Med, Web of Science, Embase, CNKI, Wanfang Data, Sino Med, and VIP were searched to collect published observational studies on the association between liver cirrhosis and fracture. The quality of each study was assessed and Rev Man5. 3 software was used to perform a meta-analysis of the risk of fracture, and the odds ratio (OR) and 95% confidence interval (CI) were calculated.Results Three cohort studies and two cross-sectional studies were included with 28 820 patients in liver cirrhosis group and 214 313 cases in control group. The analysis showed that compared with the control group, the liver cirrhosis group had a significant increase in the overall risk of fracture (all studies: OR = 2. 07, 95% CI: 1. 52-2. 83, P < 0. 000 01; cohort studies: OR = 2. 00, 95% CI: 1. 93-2. 07, P <0. 000 01) . When the patients were divided according to the type of fracture, compared with the control group, the liver cirrhosis group had significant increases in the risks of vertebral fracture and non-vertebral fracture (upper extremities) (OR = 2. 10, 95% CI: 1. 30-3. 40, P = 0. 003; OR = 1. 61, 95% CI: 1. 53-1. 69, P < 0. 000 01) . Conclusion Liver cirrhosis may increase the risk of fracture. However, due to the heterogeneity of these studies, the above results need to be further verified by more detailed studies.

     

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  • [1]HANDZLIK-ORLIK G, HOLECKI M, WILCZYNSKI K, et al.Osteoporosis in liver disease:pathogenesis and management[J].Ther Adv Endocrinol Metab, 2016, 7 (3) :128-135.
    [2]SUZUKI H.Bone complications in chronic liver disease (hepatic osteodystrophy) [J].Clin Calcium, 2015, 25 (11) :1619-1624.
    [3]LIU W, YANG LH, KONG XC, et al.Meta-analysis of osteoporosis:fracture risks, medication and treatment[J].Minerva Med, 2015, 106 (4) :203-214.
    [4]STANG A.Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses[J].Eur J Epidemiol, 2010, 25 (9) :603-605.
    [5]BANG UC, BENFIELD T, BENDTSEN F, et al.The risk of fractures among patients with cirrhosis or chronic pancreatitis[J].Clin Gastroenterol Hepatol, 2014, 12 (2) :320-326.
    [6]TSAI CF, LIU CJ, CHEN TJ, et al.Increased incidence of orthopedic fractures in cirrhotic patients:a nationwide population-based study[J].J Hepatol, 2013, 58 (4) :706-714.
    [7]ZHANG Q, CHENG J, ZHAO CS, et al.Epidemiologic study of osteoporotic vertebral compression fractures in patients with chronic hepatitis B[J].J Cervicodynia Lumbodynia, 2013, 34 (6) :441-444. (in Chinese) 张强, 成军, 赵昌松, 等.慢性乙型肝炎肝病患者骨质疏松性椎体压缩骨折的调查研究[J].颈腰痛杂志, 2013, 34 (6) :441-444.
    [8]SOLAYMANI-DODARAN M, CARD TR, AITHAL GP, et al.Fracture risk in people with primary biliary cirrhosis:a population-based cohort study[J].Gastroenterology, 2006, 131 (6) :1752-1757.
    [9]DIAMOND T, STIEL D, LUNZER M, et al.Osteoporosis and skeletal fractures in chronic liver disease[J].Gut, 1990, 31 (1) :82-87.
    [10]YAKAR S, ROSEN CJ, BEAMER WG, et al.Circulating levels of IGF-1 directly regulate bone growth and density[J].J Clin Invest, 2002, 110 (6) :771-781.
    [11]KAWELKE N, BENTMANN A, HACKL N, et al.Isoform of fibronectin mediates bone loss in patients with primary biliary cirrhosis by suppressing bone formation[J].J Bone Miner Res, 2008, 23 (8) :1278-1286.
    [12]BENTMANN A, KAWELKE N, MOSS D, et al.Circulating fibronectin affects bone matrix, whereas osteoblast fibronectin modulates osteoblast function[J].J Bone Miner Res, 2010, 25 (4) :706-715.
    [13]MOSCHEN AR, KASER A, STADLMANN S, et al.The RANKL/OPG system and bone mineral density in patients with chronic liver disease[J].J Hepatol, 2005, 43 (6) :973-983.
    [14]SHAHIN AA, SHAKER OG, KAMAL N, et al.Circulating interleukin-6, soluble interleukin-2 receptors, tumor necrosis factor alpha, and interleukin-10 levels in juvenile chronic arthritis:correlations with soft tissue vascularity assessed by power doppler sonography[J].Rheumatol Int, 2002, 22 (2) :84-88.
    [15]CHEN CH, LIN CL, KAO CH.Association between chronic hepatitis B virus infection and risk of osteoporosis:a nationwide population-based study[J].Medicine (Baltimore) , 2015, 94 (50) :e2276.
    [16]CHEN CH, LIN CL, KAO CH.Relation between hepatitis C virus exposure and risk of osteoporosis:a nationwide population-based study[J].Medicine (Baltimore) , 2015, 94 (47) :e2086.
    [17]LOPEZ-LARRAMONA G, LUCENDO AJ, GONZALEZ-DELGADO L.Alcoholic liver disease and changes in bone mineral density[J].Rev Esp Enferm Dig, 2013, 105 (10) :609-621.
    [18]GLASS LM, SU GL.Metabolic bone disease in primary biliary cirrhosis[J].Gastroenterol Clin North Am, 2016, 45 (2) :333-343.
    [19]LIAO CC, CHEN TL.Risk and adverse outcomes of fractures in patients with liver cirrhosis:two nationwide studies[J].Hepatol Int, 2016, 10 (1) :s86-s87.
    [20]SAEED NUS, GUL MA, SALIM A, et al.Frequency assessment of osteoporosis in patients of liver cirrhosis[J].Pak J Med Health Sci, 2015, 9 (1) :364-366.
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