中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 6
Jun.  2017
Turn off MathJax
Article Contents

Research advances in molecular mechanism of mother-to-child transmission of HCV and related risk factors

DOI: 10.3969/j.issn.1001-5256.2017.06.013
Research funding:

 

  • Published Date: 2017-06-20
  • Hepatitis C virus (HCV) is a global health problem and people are generally susceptible to HCV. Main routes of transmission include blood transmission, sexual transmission, and mother-to-child transmission. Anti-HCV screening of blood products has substantially reduced the blood transmission of HCV. Remarkable breakthrough has been made in the treatment of hepatitis C with direct-acting antiviral agents and the trend of HCV transmission has been significantly curbed. Since HCV infection is occult, hepatitis C vaccine has not been successfully developed, and there lack effective blocking measures for mother-to-child transmission, which will become one of the major route of HCV transmission. Reducing the rate of mother-to-child transmission of HCV is very important in preventing neonatal HCV infection and reducing the incidence rate of HCV infection. In recent years, many researchers have concentrated on the detailed mechanisms and risk factors of mother-to-child transmission of HCV and made great achievements; however, there are still controversies over some issues.This article reviews the research advances in the specific mechanisms of mother-to-child transmission of HCV in China and other countries.

     

  • loading
  • [1]TRUCCHI C, ORSI A, ALICINO C, et al.State of the art, unresolved issues, and future research directions in the fight against hepatitis C virus:perspectives for screening, diagnostics of resistances, and immunization[J].J Immunol Res, 2016, 2016 (1) :1-19.
    [2]NIE QH.Current status and progress in mother-infant infection of hepatitis C virus[J].World Chin J Dig, 2005, 13 (11) :1257-1262. (in Chinese) 聂青和.丙型肝炎病毒母婴感染研究及其预防现状[J].世界华人消化杂志, 2005, 13 (11) :1257-1262.
    [3]CHENG YQ, NIE QH, ZHOU YX.Spread mechanism of hapatitis virus C between mother and infant[J].World Chin J Dig, 2002, 10 (4) :445-447. (in Chinese) 程勇前, 聂青和, 周永兴.丙型肝炎病毒母婴传播机制研究[J].世界华人消化杂志, 2002, 10 (4) :445-447.
    [4]BONACINI M, PUOTI M.Hepatitis C in patients with human immunodeficiency virus infection:diagnosis, natural history, meta-analysis of sexual and vertical transmission, and therapeutic issues[J].Arch Intern Med, 2000, 160 (22) :3365-3373.
    [5]NIE QH, LI MD.Current status of research on hepatitis C vaccine and related strategies[J].Chin J Epidemiol, 1998, 19 (1) :49-51. (in Chinese) 聂青和, 李梦东.丙型肝炎疫苗研究现状及策略[J].中华流行病学杂志, 1998, 19 (1) :49-51.
    [6]NIE QH, LUO XD.Research on hepatitis C vaccine and challenges[J].World Chin J Dig, 2004, 12 (10) :2405-2409. (in Chinese) 聂青和, 罗新栋.丙型肝炎疫苗研究及面临的挑战[J].世界华人消化杂志, 2004, 12 (10) :2405-2409.
    [7]WANG YY, NIE QH.Research on direct-acting antiviral agents and current status of their application in treatment of chronic hepatitis C[J].Chin Hepatol, 2016, 21 (2) :140-142. (in Chinese) 王媛媛, 聂青和.直接抗病毒药物研究及其治疗慢性丙型肝炎现状[J].肝脏, 2016, 21 (2) :140-142.
    [8]NIE QH.Mother-child infection with hepatitis C virus[J].J Pract Hepatol, 2000, 5 (1) :52-53. (in Chinese) 聂青和.丙型肝炎病毒的母婴感染[J].实用肝脏病杂志, 2000, 5 (1) :52-53.
    [9]NIE QH, LI MD, HU DR, et al.Study on the cause of human protective immunodeficiency after HCV infection[J].World Chin J Dig, 2000, 8 (1) :28-30. (in Chinese) 聂青和, 李梦东, 胡大荣, 等.HCV感染后机体保护性免疫缺陷原因探讨[J].世界华人消化杂志, 2000, 8 (1) :28-30.
    [10]LUO XD, NIE QH.Features of hepatitis C in special population and related treatment measures[J].World Chin J Dig, 2004, 12 (10) :128-133. (in Chinese) 罗新栋, 聂青和.特殊人群的丙型肝炎特点及处理[J].世界华人消化杂志, 2004, 12 (10) :128-133.
    [11]PRINS JR, FAAS MM, MELGERT BN, et al.Altered expression of immune-associated genes in first-trimester human decidua of pregnancies later complicated with hypertension or foetal growth restriction[J].Placenta, 2012, 33 (5) :453-455.
    [12]ZHANG JC, SUN L, NIE QH.Isolation and further improvement of human trophoblasts in vitro[J].Lett Biotechnol, 2010, 21 (1) :58-61. (in Chinese) 张久聪, 孙利, 聂青和.人胎盘滋养层细胞原代的体外培养与改进[J].生物技术通讯, 2010, 21 (1) :58-61.
    [13]CHENG YQ, NIE QH, ZHOU YX, et al.Isolation and characteristic of villous cytotrophoblast form term human placenta and hepatitis C virus infection of human term syncytiotrophoblast cells cultured in vitro[J].J Fourth Mil Med Univ, 2002, 23 (17) :1544-1547. (in Chinese) 程勇前, 聂青和, 周永兴, 等.人胎盘滋养层细胞的分离培养及HCV体外感染试验[J].第四军医大学学报, 2002, 23 (17) :1544-1547.
    [14]GAO LH, NIE QH.Detection of hepatitis C virus in the supernatant of human placenta trophoblastic cells and cell lysates[J].J Clin Hepatol, 2011, 27 (12) :1296-1300. (in Chinese) 高禄化, 聂青和.人滋养层细胞培养上清液及裂解液中丙型肝炎病毒的检测[J].临床肝胆病杂志, 2011, 27 (12) :1296-1300.
    [15]CHENG YQ, NIE QH, ZHOU YX, et al.Change in ultrastructure of trophoblastic cells infected by hepatitis C virus in vitro[J].Chin J Obstetr Gynecol, 2003, 38 (1) :28-29. (in Chinese) 程勇前, 聂青和, 周永兴, 等.体外感染丙型肝炎病毒的滋养层细胞超微结构变化[J].中华妇产科杂志, 2003, 38 (1) :28-29.
    [16]CHENG YQ, NIE QH, ZHOU YX, et al.Ultrastructure characteristics of HCV infected human trophoblast cells in culture[J].World Chin J Dig, 2003, 11 (2) :151-156. (in Chinese) 程勇前, 聂青和, 周永兴, 等.透射电镜及激光共聚焦技术观察体外丙型肝炎病毒感染的人胎盘滋养层细胞[J].世界华人消化杂志, 2003, 11 (2) :151-156.
    [17]ZHANG YF, NIE QH, LUO XD, et al.Immunoelectron microscopy observation of HCV-like particles in the human cytotrophoblasts cultured in vitro[J].J Med Postgrad, 2005, 18 (8) :674-676. (in Chinese) 张亚飞, 聂青和, 罗新栋, 等.人滋养层细胞内丙型肝炎病毒样颗粒的免疫电镜形态学研究[J].医学研究生学报, 2005, 18 (8) :674-676.
    [18]NIE QH, GAO LH, CHENG YQ, et al.Hepatitis C virus infection of human cytotrophoblasts cultured in vitro[J].J Med Virol, 2012, 84 (10) :1586-1592.
    [19]NIE QH, ZHANG YF, LUO XD, et al.HCV infection process in the in vitro human cytotrophoblasts under transmission electron microscope[J].Chin J Infect Dis, 2005, 23 (6) :364-367. (in Chinese) 聂青和, 张亚飞, 罗新栋, 等.体外培养人胎盘滋养层细胞内吞丙型肝炎病毒过程的电镜观察[J].中华传染病杂志, 2005, 23 (6) :364-367.
    [20]NIE QH, LUO XD, ZHANG YF, et al.The study on the antibody-dependent enhancement of HCV infection in the human cytotrophoblasts cultured in vitro[J].Chin J Gastroenterol Hepatol, 2006, 15 (4) :379-382. (in Chinese) 聂青和, 罗新栋, 张亚飞, 等.HCV感染人滋养层细胞过程中抗体依赖性增强作用的初步研究[J].胃肠病学和肝病学杂志, 2006, 15 (4) :379-382.
    [21]NIKOLAEVA LI, BLOKHINA NP, TSURIKOVA NN, et al.Virus-specific antibody titres in different phases of hepatitis C virus infection[J].J Viral Hepat, 2002, 9 (6) :429-437.
    [22]CHENG YQ, NIE QH, ZHOU YX, et al.Isolation of villous cytotrophoblast from term human placenta and expression and location of Ig G FcγRⅢin human term placenta[J].J Med Postgrad, 2002, 15 (2) :105-108. (in Chinese) 程勇前, 聂青和, 周永兴, 等.人胎盘滋养层细胞的分离培养及Ig G FcγRⅢ在滋养层细胞的表达[J].医学研究生学报, 2002, 15 (2) :105-108.
    [23]NIE QH, ZHANG YF, CHENG YQ, et al.Effect of HCV persistent infection on molecular biological characteristics and invasiveness of human placental trophoblast[J].Chin J Infect Control, 2010, 9 (2) :76-80. (in Chinese) 聂青和, 张亚飞, 程勇前, 等.HCV感染实验探讨人胎盘滋养层细胞分子生物性及侵袭力[J].中国感染控制杂志, 2010, 9 (2) :76-80.
    [24]ZHANG YF, NIE QH, SHAO B, et al.Effects of HCV persistent infection on synthesis and secretion of MMP-2 and MMP-9 of human placenta l syncytiotrophoblast in vitro[J].J Fourth Mil Med Univ, 2006, 27 (21) :1949-1952. (in Chinese) 张亚飞, 聂青和, 邵彬, 等.丙型肝炎病毒持续感染对体外培养人胎盘合体滋养层细胞MMP-2和MMP-9合成分泌的影响[J].第四军医大学学报, 2006, 27 (21) :1949-1952.
    [25]ZHANG YF, NIE QH, SHAO B, et al.Effects of hepatitis C virus persistent infection on biological behavior of human placental syncytiotrophoblast in vitro[J].J Med Postgrad, 2006, 19 (2) :114-116. (in Chinese) 张亚飞, 聂青和, 邵彬, 等.丙型肝炎病毒持续感染对体外培养人胎盘合体滋养层细胞生物学性状的影响[J].医学研究生学报, 2006, 19 (2) :114-116.
    [26]GAO LH, NIE QH.The present research situation and significance of HCV ADE[J].J Clin Hepatol, 2011, 27 (8) :885-887. (in Chinese) 高禄化, 聂青和.丙型肝炎病毒抗体依赖性增强作用的研究现状及意义[J].临床肝胆病杂志, 2011, 27 (8) :885-887.
    [27]BRAMBELL FW.The transmission of immunity from mother to young and the catabolism of immunoglobulins[J].Lancet, 1966, 2 (7473) :1087-1093.
    [28]STORY CM, MIKULSKA JE, SIMISTER NE.A major histocompatibility complex class I-like Fc receptor cloned from human placenta:possible role in transfer of immunoglobulin G from mother to fetus[J].J Exp Med, 1994, 18 (6) :2377-2381.
    [29]ELLINGER I, ROTHE A, GRILL M, et al.Apical to basolateral transcytosis and apical recycling of immunoglobulin G in trophoblast-derived Be Wo cells:effects of low temperature, nocodazole, and cytochalasin D[J].Exp Cell Res, 2001, 269 (2) :322-331.
    [30]SIMISTER NE, STORY CM, CHEN HL, et al.An Ig G-transporting Fc receptor expressed in the syncytiotrophoblast of human placenta[J].Eur J Immunol, 1996, 26 (7) :1527-1531.
    [31]LEACH JL, SEDMAK DD, OSBORNE JM, et al.Isolation from human placenta of the Ig G transporter, FcRn, and localization to the syncytiotrophoblast:implications for maternal-fetal antibody transport[J].J Immunol, 1996, 157 (8) :3317-3322.
    [32]ELLINGER I, SCHWAB M, STEFANESCU A, et al.Ig G transport across trophoblast-derived Be Wo cells:a model system to study Ig G transport in the placenta[J].Eur J Immunol, 1999, 29 (3) :733-744.
    [33]KRISTOFFERSEN EK, MATRE R.Co-localization of the neonatal Fc gamma receptor and Ig G in human placental term syncytiotrophoblasts[J].Eur J Immunol, 1996, 26 (7) :1668-1671.
    [34]DAVID FJ, AUTRAN B, TRAN HC, et al.Human trophoblast cells express CD4 and are permissive for productive infection with HIV-1[J].Clin Exp Immunol, 1992, 88 (1) :10-16.
    [35]Chinese Society of Hepatology, Chinese Society of Infectious Diseases, Chinese Medical Association.The guideline of prevention and treatment for hepatitis C:a 2015 update[J].J Clin Hepatol, 2015, 31 (12) :1961-1979. (in Chinese) 中华医学会肝病学分会, 中华医学会感染病学分会.丙型肝炎防治指南 (2015年更新版) [J].临床肝胆病杂志, 2015, 31 (12) :1961-1979.
    [36]QIE QH, WANG QC.Hepatitis C virus and CD81[J].Chin Hepatol, 2002, 7 (1) :53-54. (in Chinese) 聂青和, 王全楚.丙型肝炎病毒感染与CD81分子[J].肝脏, 2002, 7 (1) :53-54.
    [37]ZHANG JC, SUN L, NIE QH.Advances in receptors and molecules associated with the entry of HCV into host cells[J].Infect Dis Info, 2009, 22 (4) :250-254. (in Chinese) 张久聪, 孙利, 聂青和.HCV受体及入胞相关分子的研究进展[J].传染病信息, 2009, 22 (4) :250-254.
    [38]LOZACH P, KHBACHER A, MEIER R, et al.DC-SIGN as a receptor for phleboviruses[J].Cell Host Microbe, 2011, 10 (1) :75-88.
    [39]CAO J, CHEN Z, REN Y, et al.Oral immunization with attenuated Salmonella carrying a co-expression plasmid encoding the core and E2 proteins of hepatitis C virus capable of inducing cellular immune responses and neutralizing antibodies in mice[J].Vaccine, 2011, 29 (20) :3714-3723.
    [40]WANG YY, NIE QH, GAO LH.The in vitro study of HCV infected of human dendritic cells interfered by CLEC4M[J].Chin Hepatol, 2013, 18 (4) :224-227. (in Chinese) 王媛媛, 聂青和, 高禄化.CLEC4M介导HCV感染人PBDC实验研究[J].肝脏, 2013, 18 (4) :224-227.
    [41]GEIJTENBEEK TB, KWON DS, TORENSMA R, et al.DCSIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells[J].Cell, 2000, 100 (5) :587-597.
    [42]LI M, NIE QH.Role of CXCL10 in pathogenesis of hepatitis C and antiviral therapy[J].J Clin Hepatol, 2015, 31 (11) :1820-1824. (in Chinese) 李汨, 聂青和.CXC趋化因子配体10在丙型肝炎发病机制和抗病毒治疗中的作用[J].临床肝胆病杂志, 2015, 31 (11) :1820-1824.
    [43]GAO LH, NIE QH, WANG YY.The distribution and location of CLEC4L in the human placental tissue and trophoblast cells[J].Chin Hepatol, 2012, 17 (9) :636-639. (in Chinese) 高禄化, 聂青和, 王媛媛.CLEC4L在人胎盘组织及滋养层细胞的分布与定位[J].肝脏, 2012, 17 (9) :636-639.
    [44]GAO LH, NIE QH, WANG YY, et al.CLEC4L-mediated HCV infection of human placental trophoblast cells[J].J Clin Hepatol, 2012, 28 (12) :941-944. (in Chinese) 高禄化, 聂青和, 王媛媛, 等.CLEC4L介导丙型肝炎病毒感染人胎盘滋养层细胞的作用机制[J].临床肝胆病杂志, 2012, 28 (12) :941-944.
    [45]KONERU A, NELSON N, HARIRI S, et al.Increased hepatitis C virus (HCV) detection in women of childbearing age and potential risk for vertical transmission-United States and Kentucky, 2011-2014[J].MMWR Morb Mortal Wkly Rep, 2016, 65 (28) :705-710.
    [46]THOMAS DL.Hepatitis C and human immunodeficiency virus infection[J].Hepatology, 2002, 36 (5) :s201-s209.
    [47]BEVILACQUA E, FABRIS A, FLOREANO P, et al.Genetic factors in mother-to-child transmission of HCV infection[J].Virology, 2009, 390 (1) :64-70.
    [48]NIE QH, WANG PZ, ZHOU YX.Quantitation of hepatitis C virus RNA in amniotic fluid of gravida infected by hepatitis C virus[J].Chin J Obstet Gynecol, 2002, 37 (1) :22-24. (in Chinese) 聂青和, 王平忠, 周永兴.丙型肝炎病毒感染孕妇羊水中丙型肝炎病毒RNA检测的临床意义[J].中华妇产科杂志, 2002, 37 (1) :22-24.
    [49]HONEGGER JR, KIM S, PRICE AA, et al.Loss of immune escape mutations during persistent HCV infection in pregnancy enhances replication of vertically transmitted viruses[J].Nat Med, 2013, 19 (11) :1529-1533.
    [50]ZALTRON S, SPINETTI A, BIASI L, et al.Chronic HCV infection:epidemiological and clinical relevance[J].BMC Infect Dis, 2012, 12 (Suppl 2) :1-7.
    [51]NIE QH, BAI XF, CHENG YQ.Advances in mechanism of transmission in pregnancy complicated by hepatitis B and hepatitis C and related preventive measures[J].Chin J Pract Gynecol Obstetr, 2004, 20 (2) :72-75. (in Chinese) 聂青和, 白雪帆, 程勇前.妊娠合并乙型肝炎丙型肝炎的传播机制及预防进展[J].中国实用妇科与产科杂志, 2004, 20 (2) :72-75.
    [52]CLARET-TERUEL G, NOGUERA-JULIAN A, ESTEVA C, et al.Impact of human immunodeficiency virus coinfection on the progression of mother-to-child transmitted hepatitis C virus infection[J].Pediatr Infect Dis J, 2011, 30 (9) :801-804.
    [53]DOWD KA, HERSHOW RC, YAWETZ S, et al.Maternal neutralizing antibody and transmission of hepatitis C virus to infants[J].J Infect Dis, 2008, 198 (11) :1651-1655.
    [54]PARTHIBAN R, SHANMUGAM S, VELU V, et al.Transmission of hepatitis C virus infection from asymptomatic mother to child in southern India[J].Int J Infect Dis, 2009, 13 (6) :e394-e400.
    [55]NIKOLOPOULOU GB, NOWICKI MJ, DU W, et al.HCV viremia is associated with drug use in young HIV-1 and HCV coinfected pregnant and non-pregnant women[J].Addiction, 2005, 100 (5) :626-635.
    [56]KANNINEN TT, DIETERICH D, ASCIUTTI S.HCV vertical transmission in pregnancy:new horizons in the era of DAAs[J].Hepatology, 2015, 62 (6) :1656-1658.
    [57]KAPLAN DE.Immunopathogenesis of hepatitis C virus infection[J].Gastroenterol Clin North Am, 2015, 44 (4) :735-760.
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Article Metrics

    Article views (2561) PDF downloads(534) Cited by()
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return