中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 6
Jun.  2017
Turn off MathJax
Article Contents

Accurate clinical examination guarantees the whole management process of hepatitis C patients in the era of direct-acting antiviral agents

DOI: 10.3969/j.issn.1001-5256.2017.06.008
  • Published Date: 2017-06-20
  • Hepatitis C virus (HCV) infection is an important public health issue around the world. Direct-acting antiviral agents (DAAs) have become an important method to reduce HCV infection. DAAs can improve the clinical outcome of antiviral therapy, shorten the course of treatment, and reduce complications and have a wide range of application; therefore, they have great advantages over conventional therapies. Accurate clinical diagnosis has increasing importance in the era of DAAs and guarantees the whole management process of chronic hepatitis C patients from the aspects of disease diagnosis, therapeutic regimens, outcome evaluation, and long-term prognosis monitoring.

     

  • loading
  • [1]KOWDLEY KV, LAWITZ E, POORDAD F, et al.Phase 2b trial of interferon-free therapy for hepatitis C virus genotype 1[J].N Engl J Med, 2014, 370 (3) :222-232.
    [2]SULKOWSKI MS, GARDINER DF, RODRGUEZ-TORRES M, et al.Daclatasvir plus sofosbuvir for previously treated or untreated chronic HCV infection[J].N Engl J Med, 2014, 370 (3) :211-221.
    [3]PAWLOTSKY JM.New hepatitis C therapies:the toolbox, strategies, and challenges[J].Gastroenterology, 2014, 146 (5) :1176-1192.
    [4]CHAYAMA K, HAYESAYES CN, OHISHI W, et al.Treatment of chronic hepatitis C virus infection in Japan:update on therapy and guidelines[J].J Gastroenterol, 2013, 48 (1) :1-12.
    [5]European Association for Study of Liver.EASL recommendations on treatment of hepatitis C 2014[J].J Hepatol, 2014, 61 (2) :373-395.
    [6]AASLD/IDSA HCV Guidance Panel.Hepatitis C guidance:AASLDIDSA recommendations for testing, managing, and treating adults infected with hepatitis C virus[J].Hepatology, 2015, 62 (3) :932-954.
    [7]Chinese Society of Hepatology and Chinese Society of Infectious Diseases, Chinese Medical Association.The guideline of prevention and treatment for hepatitis C:a 2015 update[J].J Clin Hepatol, 2015, 31 (12) :1961-1979. (in Chinese) 中华医学会肝病学分会, 中华医学会感染病学分会.丙型肝炎防治指南 (2015年更新版) [J].临床肝胆病杂志, 2015, 31 (12) :1961-1979.
    [8]GOWER E, ESTES C, BLACH S, et al.Global epidemiology and genotype distribution of the hepatitis C virus infection[J].J Hepatol, 2014, 61 (Suppl 1) :s45-s57.
    [9]SMITH DB, BUKH J, KUIKEN C, et al.Expanded classification of hepatitis C virus into 7 genotypes and 67 subtypes:updated criteria and genotype assignment web resource[J].Hepatology, 2014, 59 (1) :318-327.
    [10]MOHD HANAFIAH K, GROEGER J, FLAXMAN AD, et al.Global epidemiology of hepatitis C virus infection:new estimates of age-specific antibody to HCV seroprevalence[J].Hepatology, 2013, 57 (4) :1333-1342.
    [11]THOMAS DL.Global control of hepatitis C:where challenge meets opportunity[J].Nat Med, 2013, 19 (7) :850-858.
    [12]LIANG TJ.Current progress in development of hepatitis C virus vaccine[J].Nat Med, 2013, 19 (7) :869-878.
    [13]MAO YL, WANG H, LI BA.HCV laboratory detection and clinical application[J].Infect Dis Info, 2014, 25 (2) :75-79. (in Chinese) 毛远丽, 王晗, 李伯安.HCV实验室检测方法与临床应用[J].传染病信息, 2014, 25 (2) :75-79.
    [14]LIU SL.Detection of HCV core antigen in the diagnosis of hepatitis C[J].Continuing Med Education, 2014, 28 (4) :44-46. (in Chinese) 刘胜林.丙肝病毒核心抗原的检测在诊断丙肝中的意义[J].继续医学教育, 2014, 28 (4) :44-46.
    [15]LIAO BJ, ZHOU YC, XIE ZC, et al.Clinical application evaluation of some kinds of method in the detection of HCV antibody[J].J Mod Lab Med, 2012, 27 (4) :106-107. (in Chinese) 廖冰洁, 周迎春, 谢在春, 等.几种丙肝抗体检测的临床应用评价[J].现代检验医学杂志, 2012, 27 (4) :106-107.
    [16]LI MX, WANG XL, WU XK, et al.Comparative study on the detection of HCV-antigen, HCV-RNA and HCV-antibody detection[J].J Mod Lab Med, 2012, 27 (4) :55-56. (in Chinese) 李妙羡, 王香玲, 吴晓康, 等.HCV抗原检测与HCV-RNA和HCV抗体检测的比较研究[J].现代检验医学杂志, 2012, 27 (4) :55-56.
    [17]SIMMONDS P, HOL MES EC, CHA TA, et al.Classification of hepatitis C virus into six major genotypes and a series of subtypes by phylogenetic analysis of the NS-5 region[J].J Gen Virol, 1993, 74 (Pt11) :2391-2399.
    [18]YANG R, CONG X, DU S, et al.Performance comparison of the versant HCV genotype 2.0 assay (Li PA) and the abbott realtime HCV genotype II assay for detecting hepatitis C virus genotype 6[J].J Clin Microbiol, 2014, 52 (10) :3685-3692.
    [19]ABE H, HAYES CN, HIRAGA N, et al.A translational study of resistance emergence using sequential direct-acting antiviral agents for hepatitis C using ultra-deep sequencing[J].Am J Gastroenterol, 2013, 108 (9) :1464-1472.
    [20]LARRAT S, VALLET S, DAVID-TCHOUDA S, et al.Naturally occurring resistance associated variants of hepatitis C virus protease inhibitors in poor responders to pegylated interferon-ribavirin[J].J Clin Microbiol, 2015, 53 (7) :2195-2202.
    [21]European Association for Study of Liver;Asociacion Latinoamericana para el Estudio del Higado.EASL-ALEH clinical practice guidelines:non-invasive tests for evaluation of liver disease severity and prognosis[J].J Hepatol, 2015, 63 (1) :237-264.
    [22]European Association for Study of Liver.EASL recommendations on treatment of hepatitis C 2015[J].J Hepatol, 2015, 63 (1) :199-236.
    [23]LONG L, LIU Y, DUAN ZJ, et al.A preliminary assessment of the clinical utility of measuring hepatitis C virus antibody to evaluate infection status[J].Chin J Hepatol, 2015, 22 (4) :244-250. (in Chinese) 龙璐, 刘媛, 段昭君, 等.抗HCV抗体水平在不同HCV感染人群中的临床意义评价[J].中华肝脏病杂志, 2015, 22 (4) :244-250.
    [24]NELSON DR, COOPER JN, LALEZARI JP, et al.All-oral 12-week treatment with dacaltasvir plus sofobuvir in patients with hepatitis C virus genetype 3 infection:ALLY-3 phase III study[J].Hepatology, 2015, 61 (4) :1127-1135.
    [25]LONTOK E, HARRINGTON P, HOWE A, et al.Hepatitis C virus drug resistance-associated substitutions:state of the art summary[J].Hepatology, 2015, 62 (5) :1623-1632.
    [26]LAWITZ E, SULKOWSKI MS, GHALIB R, et al.Simeprevir plus sofosbuvir, with or without ribavirin, to treat chronic infection with hepatitis C virus genotype 1 in non-responders to pegylated interferon and ribavirin and treatment-naive patients:the COSMOS randomised study[J].Lancet, 2014, 384 (9956) :1756-1765.
    [27]LAWITZ E, POORDAD FF, PANG PS, et al.Sofosbuvir and ledipasvir fixed-dose combination with and without ribavirin in treatment-na6ve and previously treated patients with genotype 1 hepatitis C virus infection (LONESTAR) :an open-label, randomized, phase 2 trial[J].Lancet, 2014, 383 (9916) :515-523.
    [28]UCHIDA Y, KOUYAMA J, NAIKI K, et al.Significance of variants associated with resistance to NS5A inhibitors in Japanese patients with genotype 1b hepatitis C virus infection as evalued using cycling-probe real-time PCR combined with direct sequencing[J].J Gastroenterol, 2015, 51 (3) :260-270.
    [29]SUSSER S, DIETZ J, VERMEHREN J, et al.European RAVs database:frequency and characteristics of RAVs in treatment naive and DAA-experienced patients[J].J Hepatol, 2016, 64 (Suppl2) :s139.
    [30]MAASOUMY B, VERMEHREN J, WELKER MW, et al.Clinical value of on-treatment HCV RNA levels during different approved sofosbuvir-based antiviral regimens[J].J Hepatol, 2016, 65 (3) :473-482.
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Article Metrics

    Article views (2519) PDF downloads(493) Cited by()
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return