中文｜English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 4
Apr.  2017
Turn off MathJax
Article Contents
Article Navigation >  Journal of Clinical Hepatology  > 2017  >  33(4): 746-750

Research advances in the application of telbivudine during pregnancy to prevent HBV mother-to-child transmission

DOI: 10.3969/j.issn.1001-5256.2017.04.035

  • Department of Hepatology, The First Hospital of Jilin University

Research funding:

 

  • Received Date: 2016-10-09
  • Published Date: 2017-04-20
    Abstract
  • Almost 10% of neonates whose mothers have a high HBV DNA load may have HBV infection, even after the preventive treatment with hepatitis B vaccine and immune interruption. In pregnant women with a high HBV DNA load, nucleos ( t) ide analogues ( lamivudine, telbivudine, and tenofovir) have been used in the second and third trimesters to improve the interruption of mother-to-child transmission of hepatitis B. This article reviews the strategies for antiviral therapy with telbivudine for pregnant women with a high HBV DNA load in their third trimester, changes in maternal HBV DNA level after antiviral therapy, whether the success rate of interruption of mother-to-child transmission can be further increased, safety in mothers and infants, the most appropriate time for drug administration and withdrawal, and breastfeeding issues.

     

    • FullText(HTML)
  • loading
    • References(37)
  • [1]LAVANCHY D.Worldwide epidemiology of HBV infection, disease burden, and vaccine prevention[J].J Clin Virol, 2005, 34 (Suppl 1) :s1-s3.
    [2]JONAS MM.Hepatitis B and pregnancy:an underestimated issue[J].Liver Int, 2009, 29 (Suppl 1) :133-139.
    [3]STEVENS CE, BEASLEY RP, TSUI J, et al.Vertical transmission of hepatitis B antigen in Taiwan[J].N Engl J Med, 1975, 292 (15) :771-774.
    [4]BEASLEY RP, TREPO C, STEVENS CE, et al.The e antigen and vertical transmission of hepatitis B surface antigen[J].Am J Epidemiol, 1977, 105 (2) :94-98.
    [5]LEE C, GONG Y, BROK J, et al.Hepatitis B immunisation for newborn infants of hepatitis B surface antigen-positive mothers[J].Cochrane Database Syst Rev, 2006, 19 (2) :cd004790.
    [6]LEE C, GONG Y, BROK J, et al.Effect of hepatitis B immunisation in newborn infants of mothers positive for hepatitis B surface antigen:systematic review and meta-analysis[J].BMJ, 2006, 332 (7537) :328-336.
    [7]CHEN HL, LIN LH, HU FC, et al.Effects of maternal screening and universal immunization to prevent mother-to-infant transmission of HBV[J].Gastroenterology, 2012, 142 (4) :773-781.e2.
    [8]WEN WH, CHANG MH, ZHAO LL, et al.Mother-to-infant transmission of hepatitis B virus infection:significance of maternal viral load and strategies for intervention[J].J Hepatol, 2013, 59 (1) :24-30.
    [9]HAN GR, CAO MK, ZHAO W, et al.A prospective and openlabel study for the efficacy and safety of telbivudine in pregnancy for the prevention of perinatal transmission of hepatitis B virus infection[J].J Hepatol, 2011, 55 (6) :1215-1221.
    [10]HAN L, ZHANG HW, XIE JX, et al.A meta-analysis of lamivudine for interruption of mother-to-child transmission of hepatitis B virus[J].World J Gastroenterol, 2011, 17 (38) :4321-4333.
    [11]CHEN HL, LEE CN, CHANG CH, et al.Efficacy of maternal tenofovir disoproxil fumarate in interrupting mother-to-infant transmission of hepatitis B virus[J].Hepatology, 2015, 62 (2) :375-386.
    [12]PAN CQ, DUAN ZP, BHAMIDIMARRI KR, et al.An algorithm for risk assessment and intervention of mother to child transmission of hepatitis B virus[J].Clin Gastroenterol Hepatol, 2012, 10 (5) :452-459.
    [13]ZHANG H, PAN CQ, PANG Q, et al.Telbivudine or lamivudine use in late pregnancy safely reduces perinatal transmission of hepatitis B virus in real-life practice[J].Hepatology, 2014, 60 (2) :468-476.
    [14]HAN GR, JIANG HX, YUE X, et al.Efficacy and safety of telbivudine treatment:an open-label, prospective study in pregnant women for the prevention of perinatal transmission of hepatitis B virus infection[J].J Viral Hepat, 2015, 22 (9) :754-762.
    [15]PIRATVISUTH T, HAN GR, POL S, et al.Comprehensive review of telbivudine in pregnant women with chronic hepatitis B[J].World J Gastroenterol, 2016, 8 (9) :452-460.
    [16]BROWN RS Jr, Mc MAHON BJ, LOK AS, et al.Antiviral therapy in chronic hepatitis B viral infection during pregnancy:a systematic review and meta-analysis[J].Hepatology, 2016, 63 (1) :319-333.
    [17]The Asia-Pacific Society Consensus Group therapy for chronic hepatitis B liver disease.Asian-Pacific consensus statement on the management of chronic hepatitis B:a 2012 update[J].J Clin Hepatol, 2012, 28 (8) :I-XXI. (in Chinese) 亚太肝病学会慢性乙型肝炎治疗共识工作组.亚太地区慢性乙型肝炎治疗共识 (2012最新版) [J].临床肝胆病杂志, 2012, 28 (8) :I-XXI.
    [18]SARIN SK, KUMAR M, LAU GK, et al Asian-Pacific clinical practice guidelines on the management of hepatitis B:a 2015 update[J].Hepatol Int, 2015, 10 (1) :1-98.
    [19]ZHUANG H.Updates of EASL clinical practice guidelines:management of chronic hepatitis B virus infection[J].Chin J Hepatol, 2012, 20 (6) :427-429. (in Chinese) 庄辉.2012年版欧洲肝病学会慢性乙型肝炎病毒感染管理临床应用指南更新要点[J].中华肝脏病杂志, 2012, 20 (6) :427-429.
    [20]WAN MB, DOU XG.Interpretations of diagnosis and management of chronic hepatitis B in children, young people and adults by NICE (2013) [J].Chin J Hepatol, 2014, 22 (8) :561-566. (in Chinese) 万谟彬, 窦晓光.2013年版英国《儿童、青年和成人慢性乙型肝炎诊断和管理指南》解读[J].中华肝脏病杂志, 2014, 22 (8) :561-566.
    [21]Chinese Society of Hepatology and Chinese Society of Infecious Disease, Chinese Medical Association.The guideline of prevention and treatment for chironic hepatitis B:a 2015 update[J].J Clin Hepatol, 2015, 31 (12) :1941-1960. (in Chinese) 中华医学会肝病学分会, 中华医学会感染病学分会.慢性乙型肝炎防治指南 (2015年更新版) [J].临床肝胆病杂志, 2015, 31 (12) :1941-1960.
    [22]BRIDGES EG, SELDEN JR, LUO S.Nonclinical safety profile of telbivudine, a novel potent antiviral agent for treatment of hepatitis B[J].Antimicrob Agents Chemother, 2008, 52 (7) :2521-2528.
    [23]LIU M, CAI H, YI W.Safety of telbivudine treatment for chronic hepatitis B for the entire pregnancy[J].J Viral Hepat, 2013, 20 (Suppl1) :65-70.
    [24]ZHOU YJ, ZHENG JL, PAN HJ, et al.Long-term efficacy and safety of telbivudine in the treatment of childbearing patients with chronic hepatitis B[J].Chin J Hepatol, 2014, 22 (8) :573-576. (in Chinese) 周岳进, 郑金莉, 潘华将, 等.替比夫定治疗妊娠慢性乙型肝炎患者生育子女远期疗效与安全性[J].中华肝脏病杂志, 2014, 22 (8) :573-576.
    [25]WU Q, HUANG H, SUN X, et al.Telbivudine prevents vertical transmission of hepatitis B virus from women with high viral loads:a prospective long-term study[J].Clin Gastroenterol Hepatol, 2015, 13 (6) :1170-1176.
    [26]DENG M, ZHOU X, GAO S, et al.The effects of telbivudine in late pregnancy to prevent intrauterine transmission of the hepatitis B virus:a systematic review and meta-analysis[J].Virol J, 2012, 9 (1) :185.
    [27]KUBO A, SHLAGER L, CORLEY DA.Vertical transmission of hepatitis B virus-in response[J].Ann Intern Med, 2014, 161 (10) :763.
    [28]WANG C, WANG C, JIA ZF, et al.Protective effect of an improved immunization practice of mother-to-infant transmission of hepatitis B virus and risk factors associated with immunoprophylaxis failure[J].Medicine, 2016, 95 (34) :e4390.
    [29]SODERSTROM A, NORKRANS G, LINDH M.Hepatitis B virus DNA during pregnancy and post partum:aspects on vertical transmission[J].Scand J Infect Dis, 2003, 35 (11-12) :814-819.
    [30]TER BORG MJ, LEEMANS WF, de MAN RA, et al.Exacerbation of chronic hepatitis B infection after delivery[J].J Viral Hepat, 2008, 15 (1) :37-41.
    [31]SHEN JC, LENG XJ, ZHANG Y.Interpretation of managing HBV in pregnancy.prevention, prophylaxis, treatment and follow-up[J].J Clin Hepatol, 2016, 32 (6) :1060-1068. (in Chinese) 申姣春, 冷雪君, 张莹.《妊娠期HBV的阻断、预防、治疗和随访管理》解读[J].临床肝胆病杂志, 2016, 32 (6) :1060-1068.
    [32]Committee for Expert consensus on management of hepatitis B virus infection in pregnancy Expert consensus on management of hepatitis B virus infection in pregnancy[J/CD].Chin J Exp Clin Infect Dis:Electronic Edition, 2014, 8 (1) :104-107. (in Chinese) 乙型肝炎病毒感染女性生育管理专家委员会.乙型肝炎病毒感染女性生育管理专家共识[J/CD].中华实验和临床感染病杂志 (电子版) , 2014, 8 (1) :104-107.
    [33]WHITTAKER G, HERRERA JL.Hepatitis B in pregnancy[J].South Med J, 2014, 107 (3) :195-200.
    [34]PETROVA M, KAMBUROV V.Breastfeeding and chronic HBV infection:clinical and social implications[J].World J Gastroenterol, 2010, 16 (40) :5042-5046.
    [35]EHRHARDT S, XIE C, GUO N, et al.Breastfeeding while taking lamivudine or tenofovir disoproxil fumarate:a review of the evidence[J].Clin Infect Dis, 2015, 60 (2) :275-278.
    [36]BUCHANAN C, TRAN TT.Management of chronic hepatitis B in pregnancy[J].Clin Liver Dis, 2010, 14 (3) :495-504.
    [37]Expert Committee for Antiviral Therapy for Special Patients with Chronic Hepatitis B.Expert consensus on antiviral therapy for special patients with chronic hepatitis B:an update in 2015[J].J Clin Hepatol, 2015, 31 (8) :1185-1192. (in Chinese) 慢性乙型肝炎特殊患者抗病毒治疗专家委员会.慢性乙型肝炎特殊患者抗病毒治疗专家共识:2015年更新[J].临床肝胆病杂志, 2015, 31 (8) :1185-1192.
    • Relative Articles
    • Supplements(0)
    • Cited By
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索
    Get Citation
    PDF
    XML

    Article Metrics

    Article views (2135) PDF downloads(441) Cited by()
    Proportional views
    Related
        

    The first journal specializing in hepatobiliary and pancreatic diseases in China

    Supervisor：Ministry of Education of the People's Republic of China

    Sponsor：Jilin University

    Academic Support: Chinese Society of Hepatology，Chinese Medical Association

    Address: 461 Xinjiang Road, Changchun

    Submit：0431-88782044

    Peer review：0431-88783542

    Email：lcgdb@vip.163.com

    About Journal

    Submission Guideline

    Journal Online

    Hepatobiliary College

    Guidelines

    YesterdayIP[]YesterdayPV[]TodayIP[]TodayPV[]Online[]

    Website Design © 2020 Editorial Board of Journal of Clinical Hepatology 吉ICP备10000617号-1 Supported by: Beijing Renhe Information Technology Co. Ltd  

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return