中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 3
Mar.  2017
Turn off MathJax
Article Contents

Research advances in association between matrix metalloproteinases and liver fibrosis

DOI: 10.3969/j.issn.1001-5256.2017.03.037
Research funding:

 

  • Received Date: 2016-11-14
  • Published Date: 2017-03-20
  • Liver injury caused by various reasons can lead to the occurrence of liver fibrosis, which is the pathological process from chronic liver disease to liver cirrhosis.Liver fibrosis is caused by the increased synthesis and reduced degradation of extracellular matrix (ECM) .ECM is mainly degraded by matrix metalloproteinases (MMP) , and therefore, MMP play an important role in the progression and diagnosis/treatment of liver fibrosis.This article reviews the research advances in the association between MMP and liver fibrosis.

     

  • loading
  • [1]BATALLER R, BRENNER DA.Liver fibrosis[J].J Clin Invest, 2005, 115 (2) :209-218.
    [2]DUARTE S, BABER J, FUJII T, et al.Matrix metalloproteinases in liver injury, repair and fibrosis[J].Matrix Biol, 2015, 44-46:147-156.
    [3]ROBERT S, GICQUEL T, VICTONI T, et al.Involvement of matrix metalloproteinases (MMPs) and inflammasome pathway in molecular mechanisms of fibrosis[J].Biosci Rep, 2016, 36 (4) :e00360.
    [4]NIE QH, DUAN GR, LUO XD, et al.Expression of TIMP-1 and TIMP-2 in rats with hepatic fibrosis[J].World J Gastroenterol, 2004, 10 (1) :86-90.
    [5]EBRAHIMI H, NADERIAN M, SOHRABPOUR AA.New concepts on pathogenesis and diagnosis of liver fibrosis;a review article[J].Middle East J Dig Dis, 2016, 8 (3) :166.
    [6]KOCABAYOGLU P, LADE A, LEE YA, et al.β-PDGF receptor expressed by hepatic stellate cells regulates fibrosis in murine liver injury, but not carcinogenesis[J].J Hepatol, 2015, 63 (1) :141-147.
    [7]FAN TT, HU PF, WANG J, et al.Regression effect of hepatocyte nuclear factor 4αon liver cirrhosis in rats[J].J Dig Dis, 2013, 14 (6) :318-327.
    [8]MURPHY FR, ISSA R, ZHOU X, et al.Inhibition of apoptosis of activated hepatic stellate cells by tissue inhibitor of metalloproteinase-1 is mediated via effects on matrix metalloproteinase inhibition implications for reversibility of liver fibrosis[J].J Biol Chem, 2002, 277 (13) :11069-11076.
    [9]GOMIS-RUTH FX.Structural aspects of the metzincin clan of metalloendopeptidases[J].Mol Biotechnol, 2003, 24 (2) :157-202.
    [10]EGEBLAD M, WERB Z.New functions for the matrix metalloproteinases in cancer progression[J].Nat Rev Cancer, 2002, 2 (3) :161-174.
    [11]TOKITO A, JOUGASAKI M.Matrix metalloproteinases in non-neoplastic disorders[J].Int J Mol Sci, 2016, 17 (7) :1178.
    [12]JIA HZ, PENG XJ.Effect of matrix metalloproteinases in keratoconus[J].Int Eye Sci, 2016, 16 (9) :1644-1647. (in Chinese) 贾洪真, 彭秀军.基质金属蛋白酶对圆锥角膜的影响[J].国际眼科杂志, 2016, 16 (9) :1644-1647.
    [13]MURPHY G, STANTON H, COWELL S, et al.Mechanisms for pro matrix metalloproteinase activation[J].Apmis, 1999, 107 (1-6) :38-44.
    [14]BREW K, NAGASE H.The tissue inhibitors of metalloproteinases (TIMPs) :an ancient family with structural and functional diversity[J].Biochim Biophys Acta, 2010, 1803 (1) :55-71.
    [15]BREYNAERT C, de BRUYN M, ARIJS I, et al.Genetic deletion of tissue inhibitor of metalloproteinase-1/TIMP-1 alters inflammation and attenuates fibrosis in dextran sodium sulphate induced murine models of colitis[J].J Crohns Colitis, 2016, 10 (11) :1336-1350.
    [16]HERNANDEZ-GEA V, FRIEDMAN SL.Pathogenesis of liver fibrosis[J].Annu Rev Pathol, 2011, 6:425-456.
    [17]ENDO H, NIIOKA M, SUGIOKA Y, et al.Matrix metalloproteinase-13 promotes recovery from experimental liver cirrhosis in rats[J].Pathobiology, 2011, 78 (5) :239-252.
    [18]FALLOWFIELD JA, MIZUNO M, KENDALL TJ, et al.Scar-associated macrophages are a major source of hepatic matrix metalloproteinase-13 and facilitate the resolution of murine hepatic fibrosis[J].J Immunol, 2007, 178 (8) :5288-5295.
    [19]ONOZUKA I, KAKINUMA S, KAMIYA A, et al.Cholestatic liver fibrosis and toxin-induced fibrosis are exacerbated in matrix metalloproteinase-2 deficient mice[J].Biochem Biophys Res Commun, 2011, 406 (1) :134-140.
    [20]SAFADI R, FRIEDRMAN SL.Hepatic fibrosis-role of hepatic stellate cell activation[J].Med Gen Med, 2002, 4 (3) :27-27.
    [21]CAWSTON T, CARRERE S, CATTERALL J, et al.Matrix metalloproteinases and TIMPs:properties and implications for the treatment of chronic obstructive pulmonary disease[J].Novartis Found Symp, 2001, 234:205-218.
    [22]QIAO Z, LI Y, LU H, et al.Expression of tissue levels of matrix metalloproteinases and tissue inhibitors of metalloproteinases in renal cell carcinoma[J].World J Surg Oncol, 2013, 11:1.
    [23]IIMURO Y, NISHIO T, MORIMOTO T, et al.Delivery of matrix metalloproteinase-1 attenuates established liver fibrosis in the rat[J].Gastroenterology, 2003, 124 (2) :445-458.
    [24]KANDASAMY AD, CHOW AK, ALI MA, et al.Matrix metalloproteinase-2 and myocardial oxidative stress injury:beyond the matrix[J].Cardiovasc Res, 2010, 85 (3) :413-423.
    [25]ZOU LL, LIU R, LIU H, et al.Effect of agonists and inhibitorsof matrix metalloproteinases on expression of matrix metall-oproteinase 1/2 and collagen I in human scleral fibroblas[J].Chin J Ophthalmol and Otorhinolaryngol, 2013, 13 (2) :91-95. (in Chinese) 邹蕾蕾, 刘睿, 刘红, 等.MMPs激动剂和抑制剂对人巩膜成纤维细胞MMP1/2以及Ⅰ型胶原表达的作用研究[J].中国眼耳鼻喉科杂志, 2013, 13 (2) :91-95.
    [26]KOONTONGKAEW S, AMOMPHIMOLTHAM P, MONTHANPISUT P, et al.Fibroblasts and extracellular matrix differently modulate MMP activation by primary and metastatic head and neck cancer cells[J].Med Oncol, 2012, 29 (2) :690-703.
    [27]NAGASE H, VISSE R, MURPHY G.Structure and function of matrix metalloproteinases and TIMPs[J].Cardiovasc Res, 2006, 69 (3) :562-573.
    [28]HELALY GF.Differences in circulating MMP-9 levels with regard to viral load and AST:ALT ratio between chronic hepatitis B and Cpatients[J].Br J Biomed Sci, 2011, 68 (1) :38-42.
    [29]RAMACHANDRAN P, IREDALE JP.Liver fibrosis:a bidirectional model of fibrogenesis and resolution[J].QJM, 2012, 105 (9) :813-817.
    [30]LIU J, CHENG X, GUO Z, et al.Truncated active human matrix metalloproteinase-8 delivered by a chimeric adenovirus-hepatitis B virus vector ameliorates rat liver cirrhosis[J].PLoS One, 2013, 8 (1) :e53392.
    [31]SILLER-LOPEZ F, SANDOVAL A, SALGADO S, et al.Treatment with human metalloproteinase-8 gene delivery ameliorates experimental rat liver cirrhosis[J].Gastroenterology, 2004, 126 (4) :1122-1133.
    [32]YANG SW, LEE SM, CHOI EY, et al.Matrix metalloproteinase‐1 induces cleavage of exogenous alphab-crystallin transduced by a cell‐penetrating peptide[J].J Cell Biochem, 2011, 112 (9) :2454-2462.
    [33]KUO TK, HUNG SP, CHUANG CH, et al.Stem cell therapy for liver disease:parameters governing the success of using bone marrow mesenchymal stem cells[J].Gastroenterology, 2008, 134 (7) :2111-2121, e1-e3.
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Article Metrics

    Article views (2050) PDF downloads(542) Cited by()
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return