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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 10
Oct.  2016
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Research advances in venous thromboembolism in patients with liver cirrhosis

DOI: 10.3969/j.issn.1001-5256.2016.10.043
  • Received Date: 2016-06-07
  • Published Date: 2016-10-20
  • Traditionally,liver cirrhosis has a bleeding tendency due to the reduction in blood coagulation factors,hyperfibrinolysis,thrombocytopenia,and increased portal hypertension. Some studies show that the patients with live cirrhosis are in a state of hypercoagulability and tend to develop venous thromboembolism,which greatly affects the patients' prognosis. This article reviews the epidemiological features and risk factors of venous thromboembolism,as well as the significance of prevention of venous thromboembolism in patients with liver cirrhosis,so as to guide clinical practice.

     

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  • [1]TRIPODI A,SALERNO F,CHANTARANGKUL V,et al.Evidence of normal thrombin generation in cirrhosis despite abnormal conventional coagulation tests[J].Hepatology,2005,41(3):553-558.
    [2]TRIPODI A,PRIMIGNANI M,CHANTARANGKUL V,et al.An imbalance of pro-vs anti-coagulation factors in plasma from patients with cirrhosis[J].Gastroenterology,2009,137(6):2105-2111.
    [3]SOGAARD KK,HORVATHPUHO E,GRONBAEK H,et al.Risk of venous thromboembolism in patients with liver disease:a nationwide population-based case-control study[J].Am J Gastroenterol,2009,104(1):96-101.
    [4]ZHANG X,QI X,de STEFANO V,et al.Epidemiology,risk factors,and in-hospital mortality of venous thromboembolism in liver cirrhosis:a single-center retrospective observational study[J].Med Sci Monit,2016,24(22):969-976.
    [5]TSOCHATZIS EA,BOSCH J,BURROUGHS AKJ.Liver cirrhosis[J].Lancet,2014,383(9930):1749-1761.
    [6]GOLDHABER SZ,BOUNAMEAUX H.Pulmonary embolism and deep vein thrombosis[J].Lancet,2012,379(9828):1835-1846.
    [7]KYRLE A,EICHINGER S.Deep vein thrombosis[J].Lancet,2005,365(9465):1163-1174.
    [8]GOLDHABER SZ.Pulmonary embolism[J].Lancet,2004,363(9417):1295-1305.
    [9]ZHAO YQ.Research status of renous thromboembolism in China[J].Chin J Intern Med,2005,44(2):7-8.(in Chinese)赵永强.我国静脉血栓栓塞症的研究现状[J].中华内科杂志,2005,44(2):7-8.
    [10]QI X,HAN G,FAN D.Management of portal vein thrombosis in liver cirrhosis[J].Nat Rev Gastroenterol Hepatol,2014,11(7):435-446.
    [11]QI X,REN W,de STEFANO V,et al.Epidemiology of venous thromboembolism in patients with liver diseases:a systematic review and meta-analysis[J].Intern Emerg Med,2015,10(2):205-217.
    [12]ALDAWOOD A,ARABI Y,ALJUMAH A,et al.The incidence of venous thromboembolism and practice of deep venous thrombosis prophylaxis in hospitalized cirrhotic patients[J].Thromb J,2011,9(1):1.
    [13]ALI M,ANANTHAKRISHNAN AN,MCGINLEY EL,et al.Deep vein thrombosis and pulmonary embolism in hospitalized patients with cirrhosis:a nationwide analysis[J].Dig Dis Sci,2011,56(7):2152-2159.
    [14]BARCLAY SM,JEFFRES MN,NGUYEN K,et al.Evaluation of pharmacologic prophylaxis for venous thromboembolism in patients with chronic liver disease[J].Pharmacotherapy,2013,33(4):375-82.
    [15]DABBAGH O,OZA A,PRAKASH S,et al.Coagulopathy does not protect against venous thromboembolism in hospitalized patients with chronic liver disease[J].Chest,2010,137(5):1145-1149.
    [16]LESMANA CRA,INGGRIANI S,CAHYADINATA L,et al.Deep vein thrombosis in patients with advanced liver cirrhosis:a rare condition?[J].Hepatol Int,2010,4(1):433-438.
    [17]NORTHUP G,MCMAHON MM,RUHL AP,et al.Coagulopathy does not fully protect hospitalized cirrhosis patients from peripheral venous thromboembolism[J].Am J Gastroenterol,2006,101(7):1524-1528.
    [18]WALSH KA,LEWIS DA,CLIFFORD TM,et al.Risk factors for venous thromboembolism in patients with chronic liver disease[J].Ann Pharmacother,2013,47(3):333-339.
    [19]HUERTA C,JOHANSSON S,WALLANDER MA,et al.Risk factors and short-term mortality of venous thromboembolism diagnosed in the primary care setting in the United Kingdom[J].Arch Intern Med,2007,167(9):935-943.
    [20]GARCIA-FUSTER MJ,ABDILLA N,FABIA MJ,et al.Venous thromboembolism and liver cirrhosis[J].Rev Esp Enferm Dig,2008,100(5):259-262.
    [21]GULLEY D,TEAL E,SUVANNASANKHA A,et al.Deep vein thrombosis and pulmonary embolism in cirrhosis patients[J].Dig Dis Sci,2008,53(11):3012-3017.
    [22]Di MINNO MN,TUFANO A,RUSOLILLO A,et al.High prevalence of nonalcoholic fatty liver in patients with idiopathic venous thromboembolism[J].World J Gastroenterol,2010,16(48):6119-6122.
    [23]WU H,NGUYEN GC.Liver cirrhosis is associated with venous thromboembolism among hospitalized patients in a nationwide US study[J].Clin Gastroenterol Hepatol,2010,8(9):800-805.
    [24]MOOREHEAD KJ,JEFFRES MN,MUELLER SW.A retrospective cohort analysis of pharmacologic VTE prophylaxis and padua prediction score in hospitalized patients with chronic liver disease[J].J Pharm Pract,2015.[Epub ahead of print]
    [25]SHATZEL J,DULAI S,HARBIN D,et al.Safety and efficacy of pharmacological thromboprophylaxis for hospitalized patients with cirrhosis:a single-center retrospective cohort study[J].J Thromb Haemost,2015,13(7):1245-1253.
    [26]VILLA E,CAMMA C,MARIETTA M,et al.Enoxaparin prevents portal vein thrombosis and liver decompensation in patients with advanced cirrhosis[J].Gastroenterology,2012,143(5):1253-1260.
    [27]INTAGLIATA NM,HENRY Z,SHAH N,et al.Prophylactic anticoagulation for venous thromboembolism in hospitalized cirrhosis patients is not associated with high rates of gastrointestinal bleeding[J].Liver Int,2014,34(1):26-32.
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