中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 3
Mar.  2016
Turn off MathJax
Article Contents

Research advances in mesenchymal stem cells from various sources in treatment of liver fibrosis

DOI: 10.3969/j.issn.1001-5256.2016.03.044
Research funding:

 

  • Published Date: 2016-03-20
  • Mesenchymal stem cells( MSC) are derived from the mesoderm,and exhibit multipotential differentiation. MSC can alleviate liver fibrosis and improve liver function through paracrine cytokines and cell- cell interactions,but their therapeutic mechanism remains unknown. MSC are derived from various tissues,such as bone marrow,umbilical cord tissue,umbilical cord blood,peripheral blood,and adipose tissue. However,there are different advances in MSC with various sources in experimental studies and clinical treatment of liver fibrosis. This paper summarizes the possible therapeutic mechanisms of MSC in alleviating liver fibrosis,as well as the advances in experimental studies and clinical application of MSC with various sources. MSC transplantation is a new therapeutic method for liver fibrosis and has a broad application prospect in this field.

     

  • loading
  • [1]LEE KD,KUO TK,WHANG-PENG J,et al.In vitro hepatic differentiation of human mesenchymal stem cells[J].Hepatology,2004,40(6):1275-1284.
    [2]van POLL D,PAREKKADAN B,CHO CH,et al.Mesenchymal stem cell-derived molecules directly modulate hepatocellular death and regeneration in vitro and in vivo[J].Hepatology,2008,47(5):1634-1643.
    [3]KANSAS GS.Selectins and their ligands:current concepts and controversies[J].Blood,1996,88(9):3259-3287.
    [4]YU F,JI S,SU L,et al.Adipose-derived mesenchymal stem cells inhibit activation of hepatic stellate cells in vitro and ameliorate rat liver fibrosis in vivo[J].J Formos Med Assoc,2015,114(2):130-138.
    [5]LI T,YAN Y,WANG B,et al.Exosomes derived from human umbilical cord mesenchymal stem cells alleviate liver fibrosis[J].Stem Cells Dev,2013,22(6):845-854.
    [6]WANG Y,LIAN F,LI J,et al.Adipose derived mesenchymal stem cells transplantation via portal vein improves microcirculation and ameliorates liver fibrosis induced by CCl4in rats[J].J Transl Med,2012,10:133.
    [7]MEIER RP,MAHOU R,MOREL P,et al.Microencapsulated human mesenchymal stem cells decrease liver fibrosis in mice[J].J Hepatol,2015,62(3):634-641.
    [8]ZHAO DC,LEI JX,CHEN R,et al.Bone marrow-derived mesenchymal stem cells protect against experimental liver fibrosis in rats[J].World J Gastroenterol,2005,11(22):3431-3440.
    [9]SAKAIDA I,TERAI S,YAMAMOTO N,et al.Transplantation of bone marrow cells reduces CCl4-induced liver fibrosis in mice[J].Hepatology,2004,40(6):1304-1311.
    [10]MOHAMADNEJAD M,ALIMOGHADDAM K,MOHYEDDINBONAB M,et al.Phase 1 trial of autologous bone marrow mesenchymal stem cell transplantation in patients with decompensated liver cirrhosis[J].Arch Iranian Med,2007,10(4):459-466.
    [11]POPP FC,SLOWIK P,EGGENHOFER E,et al.No contribution of multipotent mesenchymal stromal cells to liver regeneration in a rat model of prolonged hepatic injury[J].Stem Cells,2007,25(3):639-645.
    [12]di BONZO LV,FERRERO I,CRAVANZOLA C,et al.Human mesenchymal stem cells as a two-edged sword in hepatic regenerative medicine:engraftment and hepatocyte differentiation versus profibrogenic potential[J].Gut,2008,57(2):223-231.
    [13]SATO Y,ARAKI H,KATO J,et al.Human mesenchymal stem cells xenografted directly to rat liver are differentiated into human hepatocytes without fusion[J].Blood,2005,106(2):756-763.
    [14]AURICH I,MUELLER LP,AURICH H,et al.Functional integration of hepatocytes derived from human mesenchymal stem cells into mouse livers[J].Gut,2007,56(3):405-415.
    [15]CAMARGO FD,FINEGOLD M,GOODELL MA.Hematopoietic myelomonocytic cells are the major source of hepatocyte fusion partners[J].J Clin Invest,2004,113(9):1266-1270.
    [16]CAPLAN AI,DENNIS JE.Mesenchymal stem cells as trophic mediators[J].J Cell Biochem,2006,98(5):1076-1084.
    [17]HAYNESWORTH SE,BABER MA,CAPLAN AI.Cytokine expression by human marrow-derived mesenchymal progenitor cells in vitro:effects of dexamethasone and IL-1 alpha[J].J Cell Physiol,1996,166(3):585-592.
    [18]CHEN S,XU L,LIN N,et al.Activation of Notch1 signaling by marrow-derived mesenchymal stem cells through cell-cell contact inhibits proliferation of hepatic stellate cells[J].Life Sci,2011,89(25-26):975-981.
    [19]SOARES JB,PIMENTEL-NUNES P,RONCON-ALBUQUERQUE RJ,et al.The role of lipopolysaccharide/toll-like receptor 4 signaling in chronic liver diseases[J].Hepatol Int,2010,4(4):659-672.
    [20]WIEST R,GARCIA-TSAO G.Bacterial translocation(BT)in cirrhosis[J].Hepatology,2005,41(3):422-433.
    [21]NOLAN JP,LEIBOWITZ AI.Endotoxin and the liver.III.Modification of acute carbon tetrachloride injury by polymyxin b-an antiendotoxin[J].Gastroenterology,1978,75(3):445-449.
    [22]WANG PP,XIE DY,LIANG XJ,et al.HGF and direct mesenchymal stem cells contact synergize to inhibit hepatic stellate cells activation through TLR4/NF-k B pathway[J].PLo S One,2012,7(8):e43408.
    [23]NASIR GA,MOHSIN S,KHAN M,et al.Mesenchymal stem cells and Interleukin-6 attenuate liver fibrosis in mice[J].J Transl Med,2013,11:78.
    [24]SHAMS S,MOHSIN S,NASIR GA,et al.Mesenchymal stem cells pretreated with HGF and FGF4 can reduce liver fibrosis in mice[J].Stem Cells Int,2015,2015:747245.
    [25]WANG HS,HUNG SC,PENG ST,et al.Mesenchymal stem cells in the Wharton's jelly of the human umbilical cord[J].Stem Cells,2004,22(7):1330-1337.
    [26]CHEN J,LIU YX,JIANG WH,et al.Differentiation of human umbilical cord mesenchymal stem cells into hepatocyte-like cells in vitro[J].J Clin Rehabilitat Tissue Engineer Res,2010,14(49):9257-9261.(in Chinese)陈军,刘玉侠,姜文华,等.体外诱导人脐带间充质干细胞向肝样细胞的分化[J].中国组织工程研究与临床康复,2010,14(49):9257-9261.
    [27]TSAI PC,FU TW,CHEN YM,et al.The therapeutic potential of human umbilical mesenchymal stem cells from wharton's jelly in the treatment of rat liver fibrosis[J].Liver Transpl,2009,15(5):484-495.
    [28]SHI M,ZHANG Z,XU R,et al.Human mesenchyrmal stem cell transfusion is safe and improves liver function in acute-on-chronic liver failure patients[J].Stem Cells Transl Med,2012,1(10):725-731.
    [29]LIN H,ZHANG Z,SHI M,et al.Evaluation on the efficacy of human umbilical cord derived-mesenchymal stem cell transplantation in liver cirrhosis patients with ascites in a prospective and control trial[J].Chin J Infect Dis,2012,30(4):204-206.(in Chinese)林沪,张政,施明,等.人脐带间充质干细胞治疗肝硬化腹水患者的前瞻性对照临床效果观察[J].中华传染病杂志,2012,30(4):204-206.
    [30]CHEN LM,XU RN,LYU S,et al.Role of human umbilical cord mesenchymal stem cells in the regulation of activation and apoptosis of hepatic stellate cell[J].Med J Chin PLA,2014,39(1):11-14.(in Chinese)陈黎明,徐若男,吕飒,等.脐带间充质干细胞对肝星状细胞活化、凋亡的调控作用研究[J].解放军医学杂志,2014,39(1):11-14.
    [31]XIANG XH,LI JP,TAN GS,et al.Control study of therapeutic effect of adipose mesenchymal stem cells and hepatocyte transplanted for hepatic cirrhosis model of rat[J/CD].Chin Arch General Surg:Electronic Version,2011,5(1):10-13.(in Chinese)向贤宏,李家平,谭国胜,等.同种异体肝细胞与脂肪间质干细胞移植治疗肝硬化的实验对照研究[J/CD].中华普通外科学文献:电子版,2011,5(1):10-13.
    [32]QU X,WANG XC,HAN L,et al.Different sources of mesenchymal stem cells in the treatment of liver fibrosis in rats[J].Chin J Tissue Engineer Res,2014,18(6):926-931.(in Chinese)曲鑫,王新超,韩璐,等.不同来源间质干细胞移植治疗大鼠肝纤维化[J].中国组织工程研究,2014,18(6):926-931.
    [33]KE CZ,LIU L,LI D,et al.Clinical effect of the intravenous administration of human umbilical cord blood mesenchymal stem cells for treating decompensated liver cirrhosis.[J].Zhejiang Clin Med J,2014,16(8):1185-1187.(in Chinese)柯昌征,刘莉,李东,等.人脐血间充质干细胞静脉移植治疗失代偿期肝硬化的疗效观察[J].浙江临床医学,2014,16(8):1185-1187.
    [34]CONG S,BAI LH,LI Y,et al.Effects of human amniotic mesenchymal stem cells transplantation on expression of HGF,SIRT-1,α-SMA and P27kip1 in CCl4-induced liver injury of mice[J].Chin J Biochem Mol Biol,2015,31(3):292-300.(in Chinese)丛姗,白立恒,李岩,等.人羊膜间充质干细胞移植对CCl4诱导的小鼠损伤肝HGF、SIRT-1、α-SMA及P27kip1表达的影响[J].中国生物化学与分子生物学报,2015,31(3):292-300.
    [35]PARK M,KIM YH,WOO SY,et al.Tonsil-derived mesenchymal stem cells ameliorate CCl4–induced liver fibrosis in mice via autophagy activation[J].Sci Rep,2015,5:8616.
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Article Metrics

    Article views (2110) PDF downloads(414) Cited by()
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return