Risk factors for hyperamylasemia after endoscopic retrograde cholangiopancreatography

Objective To investigate the risk factors for the development of post- endoscopic retrograde cholangiopancreatography pancreatitis and hyperamylasemia( PEPH) after endoscopic retrograde cholangiopancreatography( ERCP). Methods The clinical data of 233 patients who underwent therapeutic ERCP from January 2012 to December 2014 in our hospital and met the inclusion criteria were analyzed retrospectively. Basic information including age,sex,drinking history,single stone,triglyceride,and nationality was extracted,and detailed information on intraoperative procedure,intraoperative diagnosis,and complications for ERCP was carefully recorded. Chi- square test was applied for comparison of categorical data between groups,and Logistic regression analysis were applied to determine the risk factors for the development of PEPH. Results The incidence of PEPH was 26. 6%( 62 /233). Univariate analysis showed that female sex( χ2= 3. 320,P= 0. 045),drinking history( χ2= 6. 108,P = 0. 010),common bile duct stenosis( χ2= 5. 767,P = 0. 012),single stone( χ2= 9. 121,P= 0. 020),juxta- ampullary duodenal diverticula( χ2= 28. 170,P < 0. 001),and abnormal triglyceride( χ2= 54. 717,P < 0. 001) might be the risk factors for PEPH,and these factors differed significantly between the two groups. Multivariate analysis showed that female sex( OR = 1. 616,P = 0. 025) drinking history( OR = 2. 360,P = 0. 010),common bile duct stenosis( OR = 2. 163,P = 0. 012),juxta- ampullary duodenal diverticula( OR = 5. 502,P < 0. 001),and abnormal triglyceride( OR = 12. 924,P < 0. 001) were independent risk factors for PEPH. Conclusion Female sex,drinking history,common bile duct stenosis,juxta- ampullary duodenal diverticula,and abnormal triglyceride are independent risk factors for PEPH,and targeted preventive measures for such high- risk populations can effectively reduce the incidence of PEPH.