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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 32 Issue 1
Jan.  2016
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Clinical effect of systemic chemotherapy combined with transcatheter arterial chemoembolization in treatment of breast cancer with liver metastases

DOI: 10.3969/j.issn.1001-5256.2016.01.017
  • Received Date: 2015-09-02
  • Published Date: 2016-01-20
  • Objective To investigate the clinical effect of systemic chemotherapy combined with transcatheter arterial chemoembolization( TACE) in the treatment of breast cancer with liver metastases. Methods A total of 86 female breast cancer patients with liver metastases who were treated in the Affiliated Hospital of Shandong Academy of Medical Sciences from December 2012 to December 2014 were selected and equally divided into experimental group and control group. The patients in the control group received systemic chemotherapy,and those in the experimental group received systemic chemotherapy combined with TACE. The clinical effect,changes in lesions,and patients' quality of life( QOL) scores after treatment were compared between two groups. The t- test was applied for comparison of continuous data between the two groups,and the chi- square test was applied for comparison of categorical data between the two groups. Results The experimental group had a significantly higher overall response rate than the control group( 90. 70% vs 58. 14%,χ2= 13. 07,P = 0. 001). Compared with the control group,the experimental group had significantly smaller diameters of tumors and lymph nodes after treatment( t = 4. 26 and 4. 63,both P < 0. 001),as well as significantly higher QOL scores at 3 and 6 months after treatment( t = 6. 30 and 3. 89,both P <0. 001). Conclusion Systemic chemotherapy combined with TACE has a significant therapeutic effect in breast cancer patients with liver metastases,and can improve patients' symptoms,reduce adverse drug reactions,and improve QOL. As a safe and reliable therapeutic method,it is worthy of clinical application.

     

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