With the continuous development for half a century,auxiliary liver transplantation and related techniques have become more mature,and the major indications are also expanding. This article reviews the history of auxiliary liver transplantation and introduces its indications,including metabolic liver disease,fulminant hepatic failure,kidney transplantation for highly sensitized patients,and prevention of small- for- size syndrome after hepatectomy; meanwhile,this article summarizes the major surgical methods of auxiliary liver transplantation,as well as related hot issues and difficulties. On the basis of previous experience,cross- auxiliary liver transplantation has been applied to metabolic liver disease creatively,with its unique advantages in the treatment of metabolic liver disease.