The treatment responses to pegylated interferon alpha( PEG- IFNα) in patients with chronic hepatitis B( CHB) are associated with the genetic polymorphisms,immune status,hepatitis B virus genotype,and viral load of the host. This article reviews the recent studies on influential factors for the responses to PEG- IFNα in CHB patients. The important predictors of the clearance and seroconversion of HBs Ag and HBe Ag and sustained virological response include interleukin- 28B( IL- 28B) gene polymorphism,baseline level of interferon-inducible protein- 10,IL- 17 A,IL- 10,tumor necrosis factor- α,viral load and genotype,and changes in serum HBs Ag and HBe Ag levels at weeks 12 and 24 of treatment.
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