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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 1
Jan.  2014
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Prognostic factors in patients with hepatitis B- related primary liver cancer treated with transcatheter arterial chemoembolization

DOI: 10.3969/j.issn.1001-5256.2014.01.011
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  • Received Date: 2013-02-19
  • Published Date: 2014-01-20
  • Objective To analyze the prognostic factors in patients with hepatitis B- related primary liver cancer treated with transcatheter arterial chemoembolization ( TACE) and to provide a basis for properly selecting indications and treatment regimen in clinical practice. Methods A total of 140 patients with hepatitis B- related primary liver cancer, who underwent TACE in our hospital from January to December 2010, were enrolled in this study. Follow- up was continued until December 2011 to observe the patients' survival within 12 months after treatment. The Kaplan- Meier method and log- rank ( Mantel- Cox) test were used for univariate and multivariate analyses to identify the prognostic factors in patients with hepatitis B- related primary liver cancer treated with TACE. Results The univariate analysis showed that age, portal vein metastasis, peritoneal metastasis, pleural metastasis, Child- Pugh classification, bilirubin, alanine aminotransferase, number of interventional therapies, and antiviral therapy were prognostic factors in patients with hepatitis B- related primary liver cancer treated with TACE. There was significant difference in 12- month survival curve between patients treated with TACE plus antiviral therapy and those who did not receive antiviral therapy ( P < 0. 05) . The multivariate analysis showed that portal vein metastasis ( P = 0. 004) , peritoneal metastasis ( P = 0. 009) , bilirubin level ( P = 0. 017) , antiviral therapy ( P = 0. 000) , and number of TACE therapies ( P = 0. 000) were prognostic factors in patients with hepatitis B- related primary liver cancer treated with TACE. Conclusion Portal vein metastasis, peritoneal metastasis, and bilirubin level may be independent risk factors in patients with hepatitis B- related primary liver cancer treated with TACE, and antiviral therapy and number of interventional therapies may be protective factors for these patients.

     

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