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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 11
Nov.  2013
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Article Contents

Genotypes of HCV in hepatitis C patients of Han nationality in Gansu, China

DOI: 10.3969/j.issn.1001-5256.2013.11.007
  • Received Date: 2013-02-20
  • Published Date: 2013-11-20
  • Objective To investigate the genotypes of hepatitis C virus ( HCV) among the hepatitis C patients of Han nationality in Gansu, China, as well as their possible routes of transmission and relationship with clinical indices. Methods The complete data regarding hepatitis C, including sex, age, possible routes of transmission, HCV RNA level, and biochemical parameters, were collected from 220 hepatitis C patients of Han nationality in Gansu. Continuous data were analyzed by t test and rank sum test; categorical data were analyzed by chi-square test; multivariate logistic regression analysis was used to investigate the relationship between HCV genotypes and clinical indices. Results HCV genotype 1b was detected in 84 ( 38%) of all patients, and genotype 2a in 136 ( 62%) of these patients. The univariate analysis of 11 factors including age, sex, route of transmission, HCV RNA, alanine aminotransferase ( ALT) , aspartate aminotransferase ( AST) , total bilirubin ( TBil) , indirect bilirubin ( IBil) , direct bilirubin ( DBil) , alanine phosphatase ( ALP) , and gamma- glutamyl transpeptidase ( GGT) showed that the route of transmission, ALT, and HCV RNA were correlated with HCV genotypes ( χ2= 23. 947, P < 0. 001; Z=- 3. 349, P = 0. 001; t =- 2. 325, P = 0. 021) , but age, sex, AST, TBil, IBbil, DBil, ALP, and GGT were not correlated with HCV genotypes ( P > 0. 05) . The multivariate logistic regression analysis showed that the above three factors were correlated with HCV genotypes ( χ2= 3. 993, P = 0. 046; χ2= 9. 308, P = 0. 002; χ2= 11. 652, P = 0. 001) . The number of genotype 2a patients was larger than that of genotype 1b patients among patients with high HCV RNA levels ( ≥106 IU / ml) and those with high ALT levels ( > 49 U / L) . HCV genotype 1b was more likely to be transmitted by blood transfusion and oral treatment compared with other routes. Conclusion Genotype 1b and genotype 2a are the main genotypes of HCV among the hepatitis C patients of Han nationality in Gansu, and genotype 2a is more common.Genotype 2a patients are more prone to high HCV RNA level and liver damage. In Gansu, HCV is transmitted mainly by blood transfusion, followed by oral treatment, and genotype 1b is more likely than genotype 2a to be transmitted by the two routes.

     

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